| 1 | Indiana University Health INC Indianapolis, IN | $6.1B | $12.8B |
| 2 | Franciscan Alliance INC Mishawaka, IN | $3.8B | $6.3B |
| 3 | University of Notre Dame du Lac Notre Dame, IN | $3.3B | $26.7B |
| 4 | Morgan Stanley Global Impact Funding Trust INC Indianapolis, IN | $3.1B | $9.1B |
| 5 | Renaissance Charitable Foundation INC Indianapolis, IN | $2.4B | $5.9B |
| 6 | Community Health Network INC Indianapolis, IN | $2.3B | $3.0B |
| 7 | Parkview Hospital INC Fort Wayne, IN | $2.1B | $1.2B |
| 8 | Mdwise Medicaid Network INC Indianapolis, IN | $1.9B | $308.6M |
| 9 | Mdwise INC Indianapolis, IN | $1.8B | $686.2M |
| 10 | Deaconess Hospital INC Evansville, IN | $1.5B | $2.9B |
| 11 | Indiana University Health Care Associates INC Indianapolis, IN | $1.4B | $299.9M |
| 12 | National Collegiate Athletic Association Indianapolis, IN | $1.3B | $1.1B |
| 13 | Parkview Health System INC Fort Wayne, IN | $1.2B | $2.5B |
| 14 | Wabash Valley Power Association INC Indianapolis, IN | $805.6M | $1.7B |
| 15 | Indiana University Health Bloomingon INC Indianapolis, IN | $780.1M | $841.7M |
| 16 | Memorial Hospital of South Bend South Bend, IN | $746.8M | $678.0M |
| 17 | Union Hospital INC Terre Haute, IN | $737.9M | $751.3M |
| 18 | Munster Medical Research Foundation INC Munster, IN | $729.0M | $330.9M |
| 19 | Indiana University Health Arnett INC Indianapolis, IN | $662.0M | $374.4M |
| 20 | Midcontinent Independent System Operator INC Carmel, IN | $616.1M | $3.4B |
| 21 | Reid Hospital & Health Care Services INC Richmond, IN | $594.2M | $1.7B |
| 22 | Indiana University Health Ball Memorial Hospital INC Indianapolis, IN | $581.0M | $731.9M |
| 23 | Indiana University Health North Hospital INC Indianapolis, IN | $524.0M | $1.0B |
| 24 | The Methodist Hospitals INC Gary, IN | $493.4M | $364.8M |
| 25 | Indiana University Foundation Bloomington, IN | $447.8M | $4.4B |
| 26 | Community Physicians of Indiana INC Indianapolis, IN | $428.5M | $100.2M |
| 27 | Deaconess Health System INC Evansville, IN | $398.1M | $691.4M |
| 28 | Elkhart General Hospital INC Elkhart, IN | $395.2M | $269.1M |
| 29 | Indiana University Health West Hospital INC Indianapolis, IN | $392.8M | $793.3M |
| 30 | Saint Joseph Regional Medical Center-south Bend Campus INC Mishawaka, IN | $387.9M | $1.3B |
| 31 | St. Mary Medical Center INC Munster, IN | $378.4M | $211.7M |
| 32 | Community Hospitals of Indiana INC Indianapolis, IN | $341.9M | $938.8M |
| 33 | Everwise Credit Union South Bend, IN | $330.0M | $5.3B |
| 34 | Purdue Research Foundation West Lafayette, IN | $322.8M | $4.7B |
| 35 | Butler University Indianapolis, IN | $320.7M | $756.2M |
| 36 | Beacon Health System INC South Bend, IN | $302.4M | $1.3B |
| 37 | Goshen Hospital Association INC Goshen, IN | $284.1M | $412.9M |
| 38 | Church World Service INC Elkhart, IN | $283.8M | $80.6M |
| 39 | Indiana Wesleyan University Marion, IN | $269.1M | $685.7M |
| 40 | Depauw University Greencastle, IN | $256.7M | $1.3B |
| 41 | Eli Lilly & Co Master Trust for Employee Benefits Indianapolis, IN | $252.9M | $26.4M |
| 42 | Indiana University Health Plans Nfp INC Indianapolis, IN | $251.0M | $53.4M |
| 43 | Community Howard Regional Health INC Kokomo, IN | $237.5M | $424.3M |
| 44 | Trine University INC Angola, IN | $232.8M | $440.5M |
| 45 | Marion General Hospital Marion, IN | $231.5M | $533.5M |
| 46 | Community Hospital of Anderson- Madison County INC Anderson, IN | $227.3M | $415.7M |
| 47 | Beacon Medical Group INC South Bend, IN | $219.6M | $105.5M |
| 48 | Strada Education Foundation INC Indianapolis, IN | $207.7M | $1.8B |
| 49 | Marian University Indianapolis, IN | $205.5M | $368.6M |
| 50 | University of Indianapolis Indianapolis, IN | $200.7M | $284.0M |