| 1 | Wyoming Educators Benefit Trust | Unclassified | $149.3M | $49.5M |
| 2 | Sargent Foundation for Episcopal Ministries | Religion-Related | $90.6M | $8.3M |
| 3 | Delta Dental Plan of Wyoming | Unclassified | $57.6M | $26.3M |
| 4 | Cheyenne Frontier Days INC | Unclassified | $28.1M | $46.8M |
| 5 | Cheyenne Leads | Unclassified | $25.1M | $44.1M |
| 6 | Issa Foundation | Human Services | $25.0M | $24.8M |
| 7 | Laramie County Community College Foundation | Unclassified | $14.6M | $61.4M |
| 8 | Climb | Human Services | $12.9M | $10.1M |
| 9 | Bluelight Heals Corporation | Health Care | $11.9M | $64.0M |
| 10 | Stride Learning Center | Education | $8.6M | $7.6M |
| 11 | Goodwill Industries of Wyoming INC | Employment | $8.4M | $21.3M |
| 12 | Western States Learning Corporation | Education | $8.1M | $6.9M |
| 13 | Laramie County Library Foundation INC | Education | $8.1M | $12.2M |
| 14 | Cheyenne Health & Wellness Center | Health Care | $7.6M | $15.6M |
| 15 | Mary H Storer Foundation | Philanthropy, Voluntarism & Grantmaking | $7.3M | $21.1M |
| 16 | Magic City Enterprises INC | Employment | $5.6M | $3.1M |
| 17 | Pike & Susan Sullivan Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $4.6M | $8.9M |
| 18 | Cheyenne Country Club | Unclassified | $4.6M | $4.9M |
| 19 | Home Ventilating Institute | Unclassified | $3.8M | $1.5M |
| 20 | Etchepare Family Foundation | Unclassified | $3.7M | $3.9M |
| 21 | Poder Academy Incorporated | Education | $3.7M | $3.8M |
| 22 | Wyoming Education Association | Unclassified | $3.5M | $4.3M |
| 23 | Windy Ridge Foundation | Philanthropy, Voluntarism & Grantmaking | $3.5M | $4.7M |
| 24 | Cheyenne Regional Medical Center Foundation | Health Care | $3.5M | $24.7M |
| 25 | Poder Academy Secondary School | Education | $3.4M | $3.1M |
| 26 | Boys and Girls Club of Cheyenne Wyoming INC | Human Services | $3.4M | $8.2M |
| 27 | Wyoming Guardianship Corporation | Crime & Legal-Related | $3.2M | $960K |
| 28 | Wyoming School Boards Association | Unclassified | $3.0M | $7.6M |
| 29 | Cheyenne Animal Shelter-services | Animal-Related | $3.0M | $3.7M |
| 30 | Charles a Micale Foundation 01-01-98 | Philanthropy, Voluntarism & Grantmaking | $2.9M | $2.3M |
| 31 | Richardson Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.8M | $4.7M |
| 32 | Community Action of Laramie County | Human Services | $2.7M | $2.8M |
| 33 | Comea INC | Housing & Shelter | $2.6M | $5.9M |
| 34 | Anderson Donor Advised Charitable Fund | Philanthropy, Voluntarism & Grantmaking | $2.6M | $2.4M |
| 35 | Cheyenne Carriage Collection | Arts, Culture & Humanities | $2.5M | $2.5M |
| 36 | Maury and Bonnie Brown Foundation | Recreation & Sports | $2.5M | $1.0M |
| 37 | Blue Grit | Education | $2.5M | $370K |
| 38 | Kccf Charitable Trust II | Religion-Related | $2.3M | $2.3M |
| 39 | Meals on Wheels of Cheyenne INC | Food, Agriculture & Nutrition | $2.2M | $6.9M |
| 40 | Wyoming Hospital Association | Unclassified | $2.0M | $3.7M |
| 41 | Airport Golf Club INC | Unclassified | $2.0M | $1.0M |
| 42 | St. Marys School Foundation | Unclassified | $1.8M | $4.4M |
| 43 | Legal Aid of Wyoming INC | Crime & Legal-Related | $1.7M | $645K |
| 44 | Cheyenne Frontier Days Old West Museum | Arts, Culture & Humanities | $1.7M | $5.9M |
| 45 | Wyoming Association of Non Profit Organizations | Philanthropy, Voluntarism & Grantmaking | $1.7M | $507K |
| 46 | Scott and Tara Roseman Foundation | Philanthropy, Voluntarism & Grantmaking | $1.6M | $3.6M |
| 47 | Joannides Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.6M | $2.3M |
| 48 | Andrew Allen Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $1.5M | $21.6M |
| 49 | Volunteers of America Northern Rockies Foundation | Health Care | $1.5M | $1.5M |
| 50 | Wyoming Delta Dental Foundation | Philanthropy, Voluntarism & Grantmaking | $1.5M | $2.5M |
| 51 | Cheyenne Regional Air Service Focus Team | Community Improvement & Capacity Building | $1.5M | $21K |
| 52 | People to People Aid Corp. | Health Care | $1.4M | $2.4M |
| 53 | Habitat for Humanity International INC | Unclassified | $1.4M | $2.0M |
| 54 | Safehouse Services | Unclassified | $1.4M | $1.9M |
| 55 | Unaccompanied Students Initiative | Housing & Shelter | $1.4M | $2.0M |
| 56 | Wyoming 211 | Human Services | $1.4M | $670K |
| 57 | Protection & Advocacy System INC | Mental Health & Crisis Intervention | $1.4M | $364K |
| 58 | Stable Road Foundation | Education | $1.4M | $2.3M |
| 59 | Childrens Museum of Cheyenne | Arts, Culture & Humanities | $1.3M | $4.2M |
| 60 | Wyoming County Commissioners Association | Public & Societal Benefit | $1.3M | $1.4M |
| 61 | International Brotherhood of Electrical Workers | Unclassified | $1.3M | $3.2M |
| 62 | Greater Cheyenne Chamber of Commerce | Unclassified | $1.3M | $961K |
| 63 | Friends of the Cheyenne Botanic Garden | Environment | $1.2M | $2.4M |
| 64 | Cheyenne Symphony Foundation | Arts, Culture & Humanities | $1.2M | $3.7M |
| 65 | Montessori School of Cheyenne | Education | $1.2M | $2.0M |
| 66 | The Neighborhood School | Education | $1.2M | $72K |
| 67 | Wyoming Governors Residence Foundation | Unclassified | $1.2M | $2.3M |
| 68 | American Legion | Unclassified | $1.1M | $1.3M |
| 69 | Ancient & Accepted Scottish Rite of Free Masonry Southern Jurisdiction | Unclassified | $1.1M | $4.8M |
| 70 | Cheyenne Classical Academy INC | Education | $1.1M | $982K |
| 71 | Wyoming Association of Broadcasters | Unclassified | $1.1M | $1.4M |
| 72 | Wyoming Stock Growers Endowment Trust | Unclassified | $1.1M | $2.5M |
| 73 | Lifechoice Pregnancy Care Center | Unclassified | $1.1M | $1.6M |
| 74 | Wyoming Association of Municipalities | Unclassified | $1.0M | $2.8M |
| 75 | Plumbers and Pipefitters Apprenticeship Education and Train | Employment | $1.0M | $815K |
| 76 | Cheyenne Depot Museum INC | Arts, Culture & Humanities | $1.0M | $1.6M |
| 77 | Meadowlark Academy INC | Education | $970K | $5.8M |
| 78 | Wyoming Rural Electric Assn. | Unclassified | $938K | $794K |
| 79 | Caring Foundation of Wyoming INC | Human Services | $926K | $7.5M |
| 80 | Wyoming Contractors Association INC | Unclassified | $910K | $1.9M |
| 81 | Congressional Award Foundation | Public & Societal Benefit | $887K | $1.3M |
| 82 | The Alliance of Therapy Dogs | Unclassified | $849K | $953K |
| 83 | Plumbers & Pipe Fitters Local Union 192 | Unclassified | $844K | $893K |
| 84 | United Way of Laramie County | Unclassified | $835K | $557K |
| 85 | Cheyenne Symphony Orchestra | Arts, Culture & Humanities | $815K | $1.3M |
| 86 | Forum 619 INC | Unclassified | $813K | $277K |
| 87 | Wyoming Stock Growers Land Tr | Food, Agriculture & Nutrition | $803K | $6.1M |
| 88 | Kb Visions Foundation | Philanthropy, Voluntarism & Grantmaking | $787K | $1.9M |
| 89 | Ask After School for Kids | Education | $770K | $83K |
| 90 | Wyoming Association of Conservation Districts | Unclassified | $766K | $535K |
| 91 | State of Wyoming Citizen Review Panel | Human Services | $763K | $147K |
| 92 | Wyoming Family Foundation | Public & Societal Benefit | $753K | $801K |
| 93 | Wyoming Liberty Group | Civil Rights, Social Action & Advocacy | $725K | $308K |
| 94 | Wyoming Mining Association | Unclassified | $714K | $503K |
| 95 | Wyoming Bankers Association | Unclassified | $705K | $1.7M |
| 96 | Wyoming Heritage Foundation | Unclassified | $705K | $2.4M |
| 97 | Healthy Air Research and Certification Authority INC | Environment | $703K | $220K |
| 98 | Wyoming Business Alliance | Unclassified | $699K | $202K |
| 99 | Cheyenne Soccer Club | Recreation & Sports | $689K | $815K |
| 100 | Cheyenne Frontier Days Foundation INC | Arts, Culture & Humanities | $685K | $1.9M |