| 1 | Natrona Collective Health Trust | Health Care | $143.2M | $288.3M |
| 2 | John P Ellbogen Foundation | Philanthropy, Voluntarism & Grantmaking | $31.0M | $61.2M |
| 3 | Wyo Complex | Recreation & Sports | $22.9M | $43.9M |
| 4 | McMurry Foundation | Philanthropy, Voluntarism & Grantmaking | $21.2M | $22.0M |
| 5 | Community Health Center of Central Wyoming INC | Health Care | $20.9M | $19.7M |
| 6 | Central Wyoming Counseling Center | Mental Health & Crisis Intervention | $17.7M | $18.5M |
| 7 | Wyoming Machinery Company Employee Medical Benefit Trust | Unclassified | $15.9M | $2.5M |
| 8 | Wold Foundation | Unclassified | $14.8M | $53.1M |
| 9 | The Martin Family Foundation | Philanthropy, Voluntarism & Grantmaking | $11.7M | $35.9M |
| 10 | Central Wyoming Hospice Program | Unclassified | $9.5M | $14.3M |
| 11 | Casper College Foundation | Education | $8.7M | $141.5M |
| 12 | Wyoming Rescue Mission | Housing & Shelter | $7.6M | $15.0M |
| 13 | Child Development Center of Natrona County | Unclassified | $7.6M | $8.6M |
| 14 | Boys & Girls Clubs of Central Wyoming | Youth Development | $7.0M | $16.6M |
| 15 | Wyoming Health Fairs | Unclassified | $5.4M | $2.4M |
| 16 | Casper Country Club | Unclassified | $5.1M | $5.8M |
| 17 | Tw Foundation | Philanthropy, Voluntarism & Grantmaking | $4.5M | $6.0M |
| 18 | Wyoming Credit Union Ins Tr | Mutual & Membership Benefit | $4.4M | $4.6M |
| 19 | Double 4 Foundation | Philanthropy, Voluntarism & Grantmaking | $4.3M | $5.0M |
| 20 | Luther Classical College | Education | $4.0M | $4.3M |
| 21 | Boys and Girls Club of Central Wyoming Endowment Foundation INC | Youth Development | $4.0M | $12.8M |
| 22 | Jasons Friends Foundation INC | Human Services | $3.9M | $6.2M |
| 23 | Troopers Drum and Bugle Corps INC | Arts, Culture & Humanities | $3.8M | $1.9M |
| 24 | Verdad Foundation | Philanthropy, Voluntarism & Grantmaking | $3.6M | $4.3M |
| 25 | Platte River Trails Trust | Philanthropy, Voluntarism & Grantmaking | $3.4M | $9.5M |
| 26 | Wyoming Housing Network INC | Housing & Shelter | $3.3M | $21.7M |
| 27 | Natrona County Meals on Wheels | Human Services | $2.7M | $2.8M |
| 28 | Vine Foundation | Religion-Related | $2.7M | $283K |
| 29 | Wheeler Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.6M | $3.5M |
| 30 | Wyoming Independent Living Incorporated | Human Services | $2.6M | $1.2M |
| 31 | International Brotherhood of Electrical Workers | Unclassified | $2.6M | $8.2M |
| 32 | Casper Family YMCA | Unclassified | $2.5M | $26.9M |
| 33 | Serve Wyoming | Philanthropy, Voluntarism & Grantmaking | $2.5M | $418K |
| 34 | Vision Beyond Borders INC | Religion-Related | $2.4M | $2.0M |
| 35 | Focused Giving | Philanthropy, Voluntarism & Grantmaking | $2.4M | $2.4M |
| 36 | Zimmerman Family Foundation | Education | $2.1M | $1.3M |
| 37 | Wyoming High School Activities Association | Education | $2.1M | $3.5M |
| 38 | Wyoming Joint Electrical Apprenticeship and Training Trust | Employment | $1.9M | $4.6M |
| 39 | Casper Humane Society | Animal-Related | $1.9M | $5.1M |
| 40 | Matthew Shepard Foundation | Civil Rights, Social Action & Advocacy | $1.7M | $1.3M |
| 41 | Make-a-wish Foundation of Wyoming | Health Care | $1.7M | $3.9M |
| 42 | Youth Crisis Center INC | Housing & Shelter | $1.7M | $2.3M |
| 43 | Central Wyoming Junior Livestock Sale INC | Food, Agriculture & Nutrition | $1.6M | $65K |
| 44 | Leadership Wyoming | Public & Societal Benefit | $1.6M | $3.3M |
| 45 | Orrs Hope Foundation | Philanthropy, Voluntarism & Grantmaking | $1.5M | $1.2M |
| 46 | Petroleum Association of Wyoming | Community Improvement & Capacity Building | $1.5M | $991K |
| 47 | Special Olympics Wyoming INC | Unclassified | $1.5M | $755K |
| 48 | Cadoma Foundation | Arts, Culture & Humanities | $1.3M | $1.8M |
| 49 | The Joseph J Scott Foundation | Philanthropy, Voluntarism & Grantmaking | $1.3M | $4.4M |
| 50 | Blue Envelope Health Fund INC | Unclassified | $1.2M | $2.9M |
| 51 | Wyoming Realtors INC | Unclassified | $1.2M | $2.0M |
| 52 | Central Wyoming Senior Services INC | Human Services | $1.1M | $886K |
| 53 | The Caring Center INC | Unclassified | $1.1M | $2.7M |
| 54 | Habitat for Humanity International INC | Housing & Shelter | $1.1M | $1.8M |
| 55 | Mercer Family Resource Center INC | Mental Health & Crisis Intervention | $1.0M | $2.7M |
| 56 | Mountain Plains Agricultural Service | Employment | $1.0M | $441K |
| 57 | Wyoming Health Council | Health Care | $1.0M | $175K |
| 58 | United Way of Natrona County INC | Unclassified | $958K | $1.1M |
| 59 | Truecos Foundation | Philanthropy, Voluntarism & Grantmaking | $953K | $2.5M |
| 60 | Casper Area Economic Development Alliance INC | Unclassified | $942K | $4.8M |
| 61 | Goodstein Foundation | Unclassified | $932K | $5.7M |
| 62 | Science Zone | Arts, Culture & Humanities | $926K | $1.9M |
| 63 | Casper Boat Club | Unclassified | $918K | $378K |
| 64 | Meals on Wheels Foundation | Food, Agriculture & Nutrition | $916K | $4.9M |
| 65 | Tate Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $908K | $4.8M |
| 66 | St. Anthony Housing INC | Housing & Shelter | $895K | $1.9M |
| 67 | Olivia Caldwell Foundation INC | Diseases, Disorders & Medical Disciplines | $884K | $757K |
| 68 | Utility Workers Union of America Afl-cio | Unclassified | $869K | $1.2M |
| 69 | David Street Station | Community Improvement & Capacity Building | $869K | $362K |
| 70 | Casper Christian School | Education | $843K | $38K |
| 71 | Court-appointed Special Advocate of Natrona County | Human Services | $824K | $2.8M |
| 72 | Renewed Hope Foundation INC | Diseases, Disorders & Medical Disciplines | $816K | $146K |
| 73 | National Electrical Contractors Assn INC Wyoming | Unclassified | $797K | $1.6M |
| 74 | Columbia Uplift | Education | $790K | $136K |
| 75 | Child Development Center of Natrona County Foundation | Education | $780K | $7.1M |
| 76 | Hawthorn Foundation | Philanthropy, Voluntarism & Grantmaking | $764K | $1.1M |
| 77 | Ancient Free and Accepted Masons of | Unclassified | $756K | $1.2M |
| 78 | Martin and Zoe Rathvon Casper College Education Trust | Education | $750K | $1.0M |
| 79 | Two Fly Foundation INC | Philanthropy, Voluntarism & Grantmaking | $740K | $30K |
| 80 | Casper Amateur Hockey Club INC | Unclassified | $718K | $508K |
| 81 | Skyline Towers INC | Unclassified | $657K | $1.1M |
| 82 | Catholic Laity and Clergy for Renewal INC | Religion-Related | $655K | $790K |
| 83 | 12-24 Club INC | Mental Health & Crisis Intervention | $651K | $3.9M |
| 84 | Nicolaysen Art Museum | Arts, Culture & Humanities | $647K | $2.1M |
| 85 | Benevolent & Protective Order of Elks of the USA | Unclassified | $642K | $802K |
| 86 | Casper Soccer Club INC | Unclassified | $618K | $380K |
| 87 | Casper Housing Authority Cares | Housing & Shelter | $610K | $1.4M |
| 88 | Wyoming Soccer Association | Recreation & Sports | $603K | $660K |
| 89 | Arc of Natrona County | Unclassified | $595K | $547K |
| 90 | Childrens Advocacy Project INC | Health Care | $591K | $1.4M |
| 91 | The Wyoming Amateur Wrestling Association | Unclassified | $584K | $219K |
| 92 | Wyoming Wool Growers Association | Unclassified | $576K | $537K |
| 93 | Wyoming Symphony Orchestra | Unclassified | $564K | $601K |
| 94 | Wyoming Trucking Association INC | Unclassified | $564K | $183K |
| 95 | Youth for Christ USA INC | Youth Development | $557K | $854K |
| 96 | Mother Seton Housing INC | Housing & Shelter | $557K | $2.3M |
| 97 | Fraternal Order of Eagles | Unclassified | $526K | $648K |
| 98 | Izaak Walton League of America INC | Unclassified | $515K | $203K |
| 99 | Learning Junction Childrens Center INC | Human Services | $514K | $122K |
| 100 | Montessori School of Casper | Education | $506K | $1.5M |