| 1 | Genesis Healthcare System | Health Care | $761.7M | $728.1M |
| 2 | Genesis Healthcare System | Unclassified | $529.6M | $697.1M |
| 3 | J William & Mary Helen Straker Charitable Foundation | Unclassified | $53.7M | $85.4M |
| 4 | John McIntire Deceased | Unclassified | $17.8M | $18.8M |
| 5 | Muskingum County Community Foundation | Philanthropy, Voluntarism & Grantmaking | $16.0M | $36.5M |
| 6 | Zanesville Welfare Org & Goodwill Industries | Employment | $15.6M | $22.7M |
| 7 | Allwell Behavioral Health Services | Unclassified | $14.5M | $17.9M |
| 8 | Community Ambulance Service | Health Care | $10.2M | $3.9M |
| 9 | Rogge Memorial Foundation | Philanthropy, Voluntarism & Grantmaking | $6.8M | $11.8M |
| 10 | Zane State College Foundation | Education | $4.5M | $15.2M |
| 11 | Genesis Healthcare System -group Return- | Health Care | $4.5M | $80.6M |
| 12 | Zanesville Country Club | Unclassified | $4.2M | $5.5M |
| 13 | Child Care Resources INC | Education | $3.7M | $2.5M |
| 14 | Muskingum County Center for Seniors | Human Services | $3.6M | $2.6M |
| 15 | William M Shinnick Educational Fund | Unclassified | $3.3M | $8.3M |
| 16 | Helen Purcell Home | Housing & Shelter | $3.0M | $5.6M |
| 17 | Muskingum County Drug Alcohol & Substance Abuse Council INC | Mental Health & Crisis Intervention | $3.0M | $2.2M |
| 18 | George Selsam Post No 1058 Veterans of Foreign Wars of the United Stat | Public & Societal Benefit | $2.4M | $1.2M |
| 19 | Muskingum Economic Opportunity Action Group INC | Unclassified | $2.2M | $2.9M |
| 20 | Falls Township Volunteer Fire Department INC | Unclassified | $2.2M | $4.7M |
| 21 | Muskingum Residentials INC | Unclassified | $2.0M | $1.6M |
| 22 | Zanesville Day Nursery Association Zanesville Day Nursery | Unclassified | $1.9M | $9.4M |
| 23 | Ohio Rural Water Association | Unclassified | $1.8M | $2.1M |
| 24 | American Legion Auxiliary | Unclassified | $1.8M | $3.0M |
| 25 | American Legion | Unclassified | $1.7M | $2.4M |
| 26 | T R Murphy Residuary Trust | Unclassified | $1.6M | $3.0M |
| 27 | Knights Foundation INC | Education | $1.4M | $796K |
| 28 | 1246 Genesis Employees Credit Union | Unclassified | $1.4M | $20.3M |
| 29 | Big Brothers Big Sisters of Zanesville INC | Unclassified | $1.3M | $2.2M |
| 30 | Laborers International Union of North America | Unclassified | $1.3M | $2.0M |
| 31 | West Muskingum Athletic Boosters of Muskingum County Ohio | Recreation & Sports | $1.3M | $925K |
| 32 | Ohio County & Independent Agricultural Societies | Food, Agriculture & Nutrition | $1.2M | $2.5M |
| 33 | Muskingum County Senior Services Advisory Council INC | Philanthropy, Voluntarism & Grantmaking | $1.1M | $293K |
| 34 | Fraternal Order of Eagles | Unclassified | $1.1M | $1.7M |
| 35 | Zanesville Muskingum County Chamber of Commerce | Unclassified | $1.1M | $1.4M |
| 36 | Abbot Home | Unclassified | $977K | $2.3M |
| 37 | Zanesville Museum of Art | Arts, Culture & Humanities | $962K | $5.7M |
| 38 | Boy Scouts of America | Unclassified | $915K | $2.9M |
| 39 | Zanesville Lodge 867 Loyal Order of Moose | Unclassified | $914K | $716K |
| 40 | International Brotherhood of Teamsters Chauffers Warehsmn-helps | Unclassified | $865K | $570K |
| 41 | Parents Group-child Day Care Council | Unclassified | $854K | $7K |
| 42 | Eastside Community Ministry INC | Unclassified | $851K | $1.4M |
| 43 | Animal Shelter Society INC | Animal-Related | $832K | $1.7M |
| 44 | Zanesville Community Improvement Corporation | Community Improvement & Capacity Building | $824K | $1.2M |
| 45 | Muskingum Respiratory Care Association | Unclassified | $819K | $3.8M |
| 46 | Dix 1898 INC | Unclassified | $806K | $133K |
| 47 | United States Junior Chamber of Commerce | Unclassified | $774K | $198K |
| 48 | Washington Fire Department | Public Safety, Disaster Preparedness & Relief | $760K | $746K |
| 49 | United Way of Muskingum Perry & Morgan Counties INC | Philanthropy, Voluntarism & Grantmaking | $673K | $5.5M |
| 50 | The Carr Center INC | Unclassified | $619K | $896K |
| 51 | Transitions INC | Unclassified | $587K | $811K |
| 52 | East Central Career Programs INC | Employment | $550K | $51K |
| 53 | Alternacare | Health Care | $485K | $472K |
| 54 | Foreverdads | Human Services | $477K | $652K |
| 55 | The@walk | Human Services | $447K | $368K |
| 56 | Bethesda Hospital Association | Health Care | $389K | $6.5M |
| 57 | Robert E Fellers and Leona L Fellers Foundation Trust | Philanthropy, Voluntarism & Grantmaking | $365K | $3.8M |
| 58 | Guernsey-muskingum Valley Association of Realtors | Unclassified | $334K | $469K |
| 59 | Zanesville Daybreak Rotary Foundation INC | Human Services | $293K | $498K |
| 60 | West Muskingum Youth League | Youth Development | $269K | $284K |
| 61 | Muskingum Arc Housing INC | Human Services | $267K | $504K |
| 62 | Paws of Muskingum County | Animal-Related | $267K | $22K |
| 63 | Ohio Ranch Horse Association | Animal-Related | $244K | $56K |
| 64 | Friendly Hills Charitable Foundation INC | Recreation & Sports | $230K | $463K |
| 65 | Trulight Ministries | Philanthropy, Voluntarism & Grantmaking | $217K | $606K |
| 66 | The Jeff and Jennie Sidwell Family Foundation | Philanthropy, Voluntarism & Grantmaking | $208K | $400K |
| 67 | Pioneer and Historical Society of Muskingum County Ohio | Arts, Culture & Humanities | $208K | $1.3M |
| 68 | Zanesville Rotary Foundation INC | Unclassified | $205K | $601K |
| 69 | Zanesville Soccer and Riverside Park Improvement Association | Recreation & Sports | $202K | $227K |
| 70 | Coler Hospice Foundation INC | Human Services | $189K | $291K |
| 71 | Zanesville Civic League INC | Community Improvement & Capacity Building | $175K | $325K |
| 72 | Ohio Forestry Association Foundation INC | Environment | $174K | $746K |
| 73 | Licking County Farm Bureau INC | Unclassified | $174K | $186K |
| 74 | Zanesville Concert Association INC | Arts, Culture & Humanities | $166K | $113K |
| 75 | Zanesville K C Corporation | Unclassified | $161K | $184K |
| 76 | Homeless Hands of Zanesville LLC | Human Services | $157K | $183K |
| 77 | Residential Resources INC | Unclassified | $143K | $154K |
| 78 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $141K | $142K |
| 79 | Muskingum Valley Old-timers Baseball Association of Zanesville | Recreation & Sports | $134K | $82K |
| 80 | Society of Glass and Ceramic Decorated Products | Unclassified | $130K | $131K |
| 81 | Mattingly Family Foundation | Philanthropy, Voluntarism & Grantmaking | $130K | $126K |
| 82 | Knox County Farm Bureau INC | Unclassified | $129K | $250K |
| 83 | Foodworks Alliance LLC | Community Improvement & Capacity Building | $124K | $119K |
| 84 | West Muskingum Athletic Committee | Recreation & Sports | $123K | $116K |
| 85 | Rotary International | Unclassified | $118K | $115K |
| 86 | Mid-ohio Mobility Solutions INC | Human Services | $117K | $142K |
| 87 | Warriors to Wilderness Corporation | Recreation & Sports | $110K | $3K |
| 88 | Muskingum County Farm Bureau INC | Unclassified | $110K | $267K |
| 89 | Southeastern Ohio Sportsmans Association INC | Recreation & Sports | $108K | $106K |
| 90 | Veterans Appreciation Foundation | Public & Societal Benefit | $100K | $14K |
| 91 | Dirtbags Softball | Recreation & Sports | $98K | $53K |
| 92 | Nelson T Gant Foundation | Arts, Culture & Humanities | $97K | $61K |
| 93 | Rotary International | Unclassified | $95K | $46K |
| 94 | Washington County Farm Bureau INC | Unclassified | $92K | $313K |
| 95 | Coshocton County Farm Bureau INC | Unclassified | $91K | $254K |
| 96 | Communication Workers of America | Unclassified | $88K | $350K |
| 97 | West Muskingum Elementary School Boosters | Education | $84K | $137K |
| 98 | Muskingum County Hunger Network INC | Food, Agriculture & Nutrition | $81K | $56K |
| 99 | St. Nicholas Foundation | Philanthropy, Voluntarism & Grantmaking | $81K | $3.7M |
| 100 | Holmes County Farm Bureau INC | Unclassified | $79K | $115K |