| 1 | Cleveland Clinic Foundation Independence | E | $20.0B | $17.2B | $26.5B |
| 2 | Caresource Ohio INC Dayton | E | $15.4B | $8.6B | $2.2B |
| 3 | Battelle Memorial Institute Columbus | U | $13.3B | $13.3B | $1.8B |
| 4 | Bon Secours Mercy Health INC Blue Ash | E | $11.5B | $11.5B | $14.4B |
| 5 | The Cleveland Clinic Foundation Cleveland | E | $10.8B | $9.7B | $17.4B |
| 6 | Ohiohealth Corporation Grant Riverside Doctors Dublin Met Columbus | E | $7.9B | $5.1B | $10.2B |
| 7 | University Hospitals Health System INC Shaker Hts | E | $5.9B | $5.9B | $3.3B |
| 8 | Childrens Hospital Medical Center Cincinnati | E | $4.6B | $3.4B | $10.0B |
| 9 | Nationwide Childrens Hospital Columbus | Z | $4.3B | $4.3B | $9.0B |
| 10 | Childrens Hospital Medical Center of Akron Akron | E | $2.7B | $1.5B | $2.5B |
| 11 | Caresource Indiana INC Dayton | E | $2.7B | $1.3B | $437.4M |
| 12 | Case Western Reserve University Cleveland | B | $2.6B | $1.6B | $4.5B |
| 13 | Uc Healthcare System Cincinnati | E | $2.6B | $2.6B | $1.8B |
| 14 | Ohiohealth Corporation Columbus | E | $2.3B | $2.2B | $1.7B |
| 15 | Caresource Georgia Co Dayton | E | $2.3B | $1.5B | $657.1M |
| 16 | Bon Secours Richmond Health System Cincinnati | E | $2.1B | $2.0B | $0 |
| 17 | International Truck & Engine Corp Retiree Supplemental Benefit TR Richmond Hts | Z | $1.9B | $53.6M | $883.0M |
| 18 | American Endowment Foundation Hudson | T | $1.9B | $1.9B | $8.4B |
| 19 | Miami Valley Hospital Dayton | E | $1.9B | $1.6B | $1.5B |
| 20 | Jobsohio Beverage System Columbus | S | $1.8B | $730.9M | $1.2B |
| 21 | Toledo Hospital Toledo | E | $1.8B | $1.7B | $1.8B |
| 22 | Summa Health Group Return Akron | Z | $1.7B | $1.7B | $1.9B |
| 23 | Nationwide Childrens Hospital INC Columbus | E | $1.6B | $1.6B | $428.7M |
| 24 | Caresource Dayton | E | $1.5B | $1.5B | $2.8B |
| 25 | Mount Carmel Health System Columbus | Z | $1.4B | $1.4B | $3.2B |
| 26 | Christ Hospital Cincinnati | E | $1.4B | $1.4B | $1.4B |
| 27 | Cleveland Foundation Cleveland | T | $1.4B | $302.8M | $3.3B |
| 28 | Ohio State University Physicians INC Columbus | B | $1.2B | $1.1B | $528.4M |
| 29 | Kettering College Miamisburg | E | $1.2B | $1.2B | $1.5B |
| 30 | Kroger Co Health and Welfare Benefit TR for Collectively-bargai Cincinnati | Z | $1.2B | $1.2B | $0 |
| 31 | Bethesda Hospital INC Cincinnati | E | $1.1B | $917.3M | $1.3B |
| 32 | Aultman Health Foundation Group Return Canton | E | $1.1B | $1.0B | $545.6M |
| 33 | University of Dayton Dayton | B | $1.0B | $958.1M | $2.2B |
| 34 | The Good Samaritan Hospital of Cincinnati Ohio Dtd 01251995 Cincinnati | E | $983.3M | $969.0M | $1.2B |
| 35 | Adena Health System Chillicothe | E | $968.9M | $704.4M | $798.3M |
| 36 | Columbus Foundation Columbus | T | $955.8M | $411.6M | $2.8B |
| 37 | University Hospitals Health System INC Shaker Hts | E | $954.9M | $954.8M | $5.8B |
| 38 | Buckeye Power INC Columbus | Z | $915.5M | $915.5M | $1.6B |
| 39 | Dayton Osteopathic Hospital Miamisburg | E | $870.4M | $870.3M | $877.4M |
| 40 | Dayton Childrens Hospital Dayton | E | $836.6M | $741.3M | $1.8B |
| 41 | Caresource West Virginia Co Dayton | E | $802.0M | $214.7M | $139.6M |
| 42 | Genesis Healthcare System Zanesville | E | $761.7M | $759.9M | $728.1M |
| 43 | Jack Joseph and Morton Mandel Supporting Foundation Cleveland | T | $760.4M | $161.6M | $3.2B |
| 44 | Christian Healthcare Ministries INC Barberton | X | $754.7M | $754.7M | $292.8M |
| 45 | Southern Ohio Medical Center Portsmouth | E | $685.8M | $586.4M | $624.7M |
| 46 | Denison University Granville | B | $677.5M | $295.7M | $1.6B |
| 47 | Xavier University Cincinnati | B | $638.8M | $410.6M | $796.7M |
| 48 | Childrens Hospital Cincinnati | E | $625.3M | $240.5M | $5.4B |
| 49 | 0005 Wright-patt Credit Union Beavercreek | Z | $600.7M | $600.7M | $9.1B |
| 50 | Mount Carmel Health Plan INC Columbus | E | $598.5M | $598.5M | $501.8M |