| 1 | Youngstown State University Foundation | Education | $100.6M | $392.0M |
| 2 | Shepherd of the Valley Lutheran Retirement Services INC | Human Services | $58.7M | $107.7M |
| 3 | Direction Home of Eastern Ohio INC | Human Services | $46.7M | $21.2M |
| 4 | Second Harvest Foodbank of the Mahoning Valley | Food, Agriculture & Nutrition | $32.9M | $20.4M |
| 5 | Gateways to Better Living INC | Human Services | $26.0M | $8.9M |
| 6 | Ohio North East Health Systems INC | Health Care | $24.1M | $15.9M |
| 7 | Reuben McMillan Free Library Association | Education | $23.2M | $96.0M |
| 8 | Youngstown Area Jewish Federation | Philanthropy, Voluntarism & Grantmaking | $20.9M | $16.7M |
| 9 | Community Foundation of Mahoning Valley | Philanthropy, Voluntarism & Grantmaking | $20.9M | $50.1M |
| 10 | Alta Care Group INC | Mental Health & Crisis Intervention | $19.7M | $13.7M |
| 11 | Butler Institute of American Art | Arts, Culture & Humanities | $19.5M | $75.3M |
| 12 | State Power Fund | Human Services | $19.5M | $15.1M |
| 13 | Meridian Healthcare | Unclassified | $18.2M | $13.6M |
| 14 | Anne Kilcawley Christman Foundation | Philanthropy, Voluntarism & Grantmaking | $16.8M | $50.9M |
| 15 | Young Mens Christian Association Youngstown Oh | Human Services | $16.1M | $42.6M |
| 16 | Tod Homestead Cemetery Association | Unclassified | $15.0M | $39.9M |
| 17 | Youngstown Area Goodwill Industries INC | Unclassified | $14.3M | $8.9M |
| 18 | Mahoning County Community Corrections Assoc INC | Unclassified | $13.3M | $11.4M |
| 19 | Ohio Organizing Campaign | Civil Rights, Social Action & Advocacy | $10.8M | $5.0M |
| 20 | The Ohio Organzing Collaborative | Public & Societal Benefit | $10.0M | $10.0M |
| 21 | Potential Development Program | Human Services | $9.5M | $7.0M |
| 22 | Mahoning Youngstown Community Action Partnership | Human Services | $9.1M | $2.7M |
| 23 | Youngstown Area Jewish Foundation | Religion-Related | $9.1M | $52.8M |
| 24 | Youngstown Neighborhood Development Corporation | Housing & Shelter | $8.6M | $9.7M |
| 25 | Marion G Resch Foundation | Philanthropy, Voluntarism & Grantmaking | $8.4M | $19.2M |
| 26 | Mahoning Valley Historical Society | Arts, Culture & Humanities | $8.0M | $11.9M |
| 27 | The Youngstown Edison Incubator Corporation | Community Improvement & Capacity Building | $7.7M | $16.3M |
| 28 | Valley Economic Development Partners INC | Community Improvement & Capacity Building | $7.5M | $46.9M |
| 29 | Safe House Ministries INC | Human Services | $7.5M | $9.7M |
| 30 | The United Way of Youngstown and the Mahoning Valley | Philanthropy, Voluntarism & Grantmaking | $7.5M | $16.1M |
| 31 | Trumbull Memorial Health Foundation | Health Care | $7.3M | $18.3M |
| 32 | Horizon Science Academy Youngstown INC | Education | $7.1M | $14.0M |
| 33 | Youth Intensive Services | Youth Development | $7.0M | $4.4M |
| 34 | Mahoning Valley Historical Society Foundation INC | Philanthropy, Voluntarism & Grantmaking | $6.9M | $4.5M |
| 35 | Western Reserve Health Foundation | Health Care | $6.5M | $18.2M |
| 36 | Youngstown Community School INC | Education | $6.3M | $7.1M |
| 37 | Gateways Industries INC | Mental Health & Crisis Intervention | $4.9M | $1.2M |
| 38 | Youngstown Foundation | Philanthropy, Voluntarism & Grantmaking | $4.6M | $152.5M |
| 39 | Kikel Charitable Foundation Ua 101097 | Health Care | $4.6M | $12.2M |
| 40 | Warriors INC | Community Improvement & Capacity Building | $4.5M | $12.5M |
| 41 | The Mahoning County High School | Education | $4.5M | $3.8M |
| 42 | Rescue Mission of Mahoning Valley | Housing & Shelter | $4.1M | $11.9M |
| 43 | Youngstown Academy of Excellence | Education | $4.0M | $4.7M |
| 44 | Penguin Club | Unclassified | $3.8M | $4.1M |
| 45 | Flying High INC | Human Services | $3.8M | $3.3M |
| 46 | Easterseals of Northeast Ohio | Health Care | $3.6M | $7.8M |
| 47 | Help Hotline Crisis Center INC | Unclassified | $3.4M | $3.7M |
| 48 | State Power Action Fund | Civil Rights, Social Action & Advocacy | $3.3M | $2.6M |
| 49 | Youngstown Country Club | Unclassified | $3.1M | $3.7M |
| 50 | South Side Academy INC | Education | $3.1M | $2.5M |
| 51 | Youngstown-warren Regional Chamber | Unclassified | $3.0M | $1.8M |
| 52 | YWCA Mahoning Valley | Human Services | $2.8M | $8.6M |
| 53 | Animal Charity of Ohio INC | Animal-Related | $2.7M | $3.6M |
| 54 | William Swanston Charitable Fund | Human Services | $2.7M | $9.4M |
| 55 | Blackburn Home for Aged People Association | Unclassified | $2.7M | $6.1M |
| 56 | Catholic Charities Regional Agency | Community Improvement & Capacity Building | $2.7M | $824K |
| 57 | Veterans Outreach | Philanthropy, Voluntarism & Grantmaking | $2.6M | $1.2M |
| 58 | Henry H Stambaugh Auditorium Association | Arts, Culture & Humanities | $2.6M | $9.4M |
| 59 | John & Denise York Foundation | Philanthropy, Voluntarism & Grantmaking | $2.6M | $5.7M |
| 60 | Youngstown Symphony Society INC | Arts, Culture & Humanities | $2.5M | $9.1M |
| 61 | Edward J Debartolo Memorial Scholarship Foundation | Education | $2.0M | $3.3M |
| 62 | James & Coralie Centofanti Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $1.9M | $6.8M |
| 63 | Shepherds Foundation INC | Health Care | $1.9M | $4.2M |
| 64 | International Brotherhood of Teamsters | Unclassified | $1.9M | $1.9M |
| 65 | Youngstown Central Area Community Improvement Corporation | Community Improvement & Capacity Building | $1.9M | $5.7M |
| 66 | Lake to River Foundation INC | Community Improvement & Capacity Building | $1.9M | $822K |
| 67 | Friends of Fellows Riverside Gardens INC | Unclassified | $1.9M | $3.8M |
| 68 | Commission for Jewish Education of Greater Youngstown | Religion-Related | $1.8M | $371K |
| 69 | Ohio Valley Teen Challenge INC | Unclassified | $1.8M | $2.8M |
| 70 | All Children Learn Differently School | Unclassified | $1.8M | $2.2M |
| 71 | Masco INC | Unclassified | $1.6M | $3.8M |
| 72 | Mahoning Valley Chapter National Electrical Contractors Assn INC | Unclassified | $1.6M | $2.0M |
| 73 | Habitat for Humanity International INC | Unclassified | $1.6M | $3.3M |
| 74 | Beatitude House | Unclassified | $1.6M | $1.9M |
| 75 | Catholic War Veterans of the United States of America INC | Unclassified | $1.5M | $86K |
| 76 | Hospice of the Valley | Human Services | $1.5M | $13.4M |
| 77 | Mahoning Valley Manufacturers Coalition INC | Community Improvement & Capacity Building | $1.5M | $1.2M |
| 78 | Building Neighborhoods of Youngstown | Community Improvement & Capacity Building | $1.4M | $70K |
| 79 | Society of St. Vincent de Paul Mahoning District Council INC | Human Services | $1.4M | $706K |
| 80 | Paisley House | Human Services | $1.4M | $4.6M |
| 81 | Youngstown Preparatory Academy | Education | $1.4M | $1.2M |
| 82 | Mahoning Valley Manufacturers Foundation INC | Community Improvement & Capacity Building | $1.4M | $0 |
| 83 | Broadway Recovery Services | Housing & Shelter | $1.3M | $582K |
| 84 | Youngstown Urban Minority Alcoholism & Drug Abuse Outreach P | Mental Health & Crisis Intervention | $1.3M | $341K |
| 85 | Youngstown Cityscape INC | Community Improvement & Capacity Building | $1.3M | $2.0M |
| 86 | International Brotherhood of Electrical Workers | Unclassified | $1.2M | $3.0M |
| 87 | Margaret M Walker Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $1.2M | $2.7M |
| 88 | Matthias Media Ministries | Religion-Related | $1.1M | $441K |
| 89 | Oh Wow the Roger & Gloria Jones Childrens Center for Science & Tec | Arts, Culture & Humanities | $1.1M | $3.7M |
| 90 | Plaza View INC | Housing & Shelter | $1.1M | $1.2M |
| 91 | David W Edward Charitable Fund | Philanthropy, Voluntarism & Grantmaking | $1.1M | $4.1M |
| 92 | Carter House | Human Services | $1.1M | $401K |
| 93 | Belmont Park Cemetery Association | Unclassified | $1.1M | $2.4M |
| 94 | Better Business Bureau of Mahoning Valley INC | Unclassified | $1.1M | $1.7M |
| 95 | Montessori School of the Mahoning Valley | Education | $1.1M | $806K |
| 96 | Project Mkc | Youth Development | $1.1M | $233K |
| 97 | Ohio Nurses Association District Three Williamsburg West | Unclassified | $1.0M | $0 |
| 98 | Heart Reach Neighborhood Ministries | Religion-Related | $972K | $483K |
| 99 | St. Johns Greek Orthodox Church Endowment Fund | Unclassified | $959K | $1.7M |
| 100 | Boys & Girls Club of Youngstown | Unclassified | $955K | $745K |