| 1 | Southern Ohio Medical Center | Health Care | $685.8M | $624.7M |
| 2 | Somc Medical Care Foundation INC | Health Care | $55.7M | $16.2M |
| 3 | Scioto County Counseling Center INC | Mental Health & Crisis Intervention | $50.0M | $43.0M |
| 4 | Portsmouth Hospital Corporation | Health Care | $30.2M | $28.9M |
| 5 | Community Action Organization of Scioto County INC | Human Services | $23.3M | $10.0M |
| 6 | Shawnee Mental Health Center INC | Unclassified | $19.6M | $20.3M |
| 7 | Hillview Retirement Center | Human Services | $17.0M | $18.7M |
| 8 | Shawnee State University Development Foundation | Education | $11.0M | $39.2M |
| 9 | Compass Community Health | Health Care | $6.6M | $6.9M |
| 10 | The Scioto County Area Foundation | Philanthropy, Voluntarism & Grantmaking | $5.7M | $65.4M |
| 11 | International Brotherhood of Electrical Workers | Unclassified | $5.4M | $5.6M |
| 12 | Scioto Residential Services INC | Human Services | $5.2M | $6.0M |
| 13 | Southern Ohio Medical Center Title Holding Company | Unclassified | $4.9M | $59.4M |
| 14 | Star INC | Employment | $3.7M | $4.0M |
| 15 | Osco Employees Health & Welfare Trust Eleventh & Chillicothe Sts | Unclassified | $3.5M | $43K |
| 16 | Laborers International Union of North America | Unclassified | $3.4M | $9.6M |
| 17 | Portsmouth Electrical Joint Apprenticeship & Training Trust Fu | Unclassified | $3.4M | $3.5M |
| 18 | Southern Ohio Medical Center | Health Care | $2.8M | $7.2M |
| 19 | Clyde and Maycel Clark Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.2M | $18.0M |
| 20 | The Glockner Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.2M | $12.0M |
| 21 | Portsmouth Stem Academy | Education | $1.9M | $4.5M |
| 22 | American Legion | Unclassified | $1.8M | $416K |
| 23 | Surviving Our Losses and Continuing Everyday INC | Mental Health & Crisis Intervention | $1.7M | $1.3M |
| 24 | United Association of Journeymen & Apprentices of the Plumbing & Pipe | Unclassified | $1.5M | $3.0M |
| 25 | Fraternal Order of Eagles | Unclassified | $1.4M | $1.0M |
| 26 | Compass Point Housing | Crime & Legal-Related | $1.1M | $3.9M |
| 27 | Southern Ohio Museum Corporation | Arts, Culture & Humanities | $884K | $6.4M |
| 28 | United Scioto Senior Activities | Unclassified | $716K | $550K |
| 29 | Friends of Southern Ohio | Community Improvement & Capacity Building | $647K | $336K |
| 30 | American Legion | Unclassified | $623K | $198K |
| 31 | Choice Housing | Housing & Shelter | $538K | $1.7M |
| 32 | Sierras Haven for New and Used Pets | Animal-Related | $488K | $581K |
| 33 | Southern Ohio Area Task Force on Domestic Violence | Human Services | $480K | $395K |
| 34 | Scioto Christian Ministry INC | Human Services | $450K | $307K |
| 35 | Masonic Temple Company | Unclassified | $450K | $782K |
| 36 | Scioto County Childrens Museum INC | Arts, Culture & Humanities | $359K | $625K |
| 37 | Market Square Park LLC | Unclassified | $335K | $635K |
| 38 | Steven a Hunter Hope Fund INC | Education | $313K | $598K |
| 39 | United Brotherhood of Carpenters & Joiners of America | Unclassified | $303K | $1.1M |
| 40 | Cyrus P Kahl and Alma F Kahl Foundation INC | Philanthropy, Voluntarism & Grantmaking | $292K | $1.1M |
| 41 | Hilltop Initiative Neighborhood Association | Community Improvement & Capacity Building | $283K | $228K |
| 42 | Saint Francis Catholic Outreach & Charitable Giving INC | Religion-Related | $273K | $482K |
| 43 | Lore Family Ministries INC | Religion-Related | $272K | $32K |
| 44 | Portsmouth Inner City Development Corp Housing Assoc I | Housing & Shelter | $251K | $537K |
| 45 | Shawnee Housing Association | Housing & Shelter | $209K | $484K |
| 46 | Portsmouth Inner-city Development Corporation | Housing & Shelter | $201K | $699K |
| 47 | Portsmouth Area Chamber of Commerce | Unclassified | $196K | $61K |
| 48 | Richard and Fern Cielec Foundation | Philanthropy, Voluntarism & Grantmaking | $196K | $915K |
| 49 | Main Street Portsmouth | Arts, Culture & Humanities | $193K | $292K |
| 50 | Cradle INC | Religion-Related | $179K | $181K |
| 51 | Potters House Ministries INC | Human Services | $167K | $23K |
| 52 | Southeastern Ohio Education Assoc | Community Improvement & Capacity Building | $157K | $668K |
| 53 | Portsmouth Inner City Development Corporation Housing Association II | Unclassified | $155K | $602K |
| 54 | Boneyfiddle Project | Arts, Culture & Humanities | $153K | $74K |
| 55 | Portsmouth Murals INC | Arts, Culture & Humanities | $152K | $297K |
| 56 | Greater Portsmouth Area Tourist & Convention Council | Unclassified | $151K | $111K |
| 57 | Wings of Hope Recovery Services | Mental Health & Crisis Intervention | $136K | $211K |
| 58 | Portsmouth Area Arts Council INC | Unclassified | $127K | $50K |
| 59 | Fourteenth Street Community Center | Unclassified | $127K | $750K |
| 60 | 0987 S C F E Credit Union INC | Unclassified | $78K | $1.3M |
| 61 | Aurora Lodge No 48 F & Am | Unclassified | $76K | $616K |
| 62 | Forensic Nursing INC | Mental Health & Crisis Intervention | $74K | $124K |
| 63 | Shawnee Boating Club INC | Unclassified | $72K | $30K |
| 64 | Rotary International | Unclassified | $62K | $48K |
| 65 | Friends of Greenlawn Cemetery Foundation | Public & Societal Benefit | $59K | $29K |
| 66 | Dogs to the Rescue | Animal-Related | $56K | $42 |
| 67 | Plumbers & Pipefitters Local Union No 577 Building Corporation | Unclassified | $36K | $453K |
| 68 | Osco Industries Foundation | Unclassified | $25K | $98K |
| 69 | Refuge Southern Ohio INC | Religion-Related | $25K | $97K |
| 70 | Living with a Cause INC | Human Services | $23K | $2K |
| 71 | United Way of Scioto & Adams Counties | Unclassified | $4K | $132K |
| 72 | Portsmouth Ll 1351110 | Recreation & Sports | $0 | $0 |
| 73 | Friends of Shawnee State Park INC | Recreation & Sports | $0 | $0 |
| 74 | C and L Transportation Fund INC | Human Services | $0 | $0 |
| 75 | Connex | Recreation & Sports | $0 | $0 |
| 76 | Ohio State University | Youth Development | $0 | $0 |
| 77 | Scioto Area Real Estate Foundationinc | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 78 | Scioto County Historical Society | Arts, Culture & Humanities | $0 | $0 |
| 79 | Royal Arch Masons of Ohio | Unclassified | $0 | $0 |
| 80 | American Postal Workers Union | Unclassified | $0 | $0 |
| 81 | American Federation of State County & Municipal Employees | Unclassified | $0 | $0 |
| 82 | Plumbers & Steamfitters Joint Appre Ntice Trng Program | Education | $0 | $1.4M |
| 83 | Trinity Lodge No 9 Prince Hall Free & Accepted Masons | Mutual & Membership Benefit | $0 | $0 |
| 84 | Scenic Scioto Heritage Trail INC | Arts, Culture & Humanities | $0 | $0 |
| 85 | The Ohio State University | Youth Development | $0 | $0 |
| 86 | Spirit Life and Truth House of Prayer | Religion-Related | $0 | $0 |
| 87 | The Ohio State University | Youth Development | $0 | $0 |
| 88 | Southern Ohio Senior Games | Recreation & Sports | $0 | $0 |
| 89 | Aglow International | Unclassified | $0 | $0 |
| 90 | Sciotodale Free Will Baptist Church | Unclassified | $0 | $0 |
| 91 | Revive Church of the Nazarene | Unclassified | $0 | $0 |
| 92 | Christians Beyond Church at Highland Ave | Unclassified | $0 | $0 |
| 93 | Apostolic Gospel Church INC | Unclassified | $0 | $0 |
| 94 | International Pentecostal Church of Christ | Unclassified | $0 | $0 |
| 95 | International Pentecostal Church of Christ Highland Oh | Unclassified | $0 | $0 |
| 96 | Scioto County Chapter of the Ohio Genealogical Society | Unclassified | $0 | $0 |
| 97 | Living Faith Temple Incorporated | Religion-Related | $0 | $0 |
| 98 | Gateway Church of God | Unclassified | $0 | $0 |
| 99 | Riverview Wesleyan Church | Unclassified | $0 | $0 |
| 100 | Scioto County Right to Life | Unclassified | $0 | $0 |