| 1 | Defiance College | Education | $27.7M | $41.6M |
| 2 | Northwestern Ohio Community Action INC | Human Services | $14.1M | $7.8M |
| 3 | Defiance Area Foundation INC | Unclassified | $13.6M | $17.5M |
| 4 | Amvets | Unclassified | $10.0M | $556K |
| 5 | Recovery Services of Northwest Ohio INC | Health Care | $6.3M | $4.1M |
| 6 | Maumee Valley Guidance Center INC | Mental Health & Crisis Intervention | $5.7M | $9.2M |
| 7 | Justin F Coressel Charitable Tr | Unclassified | $3.6M | $4.3M |
| 8 | Knapp Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.1M | $2.1M |
| 9 | Fraternal Order of Eagles | Unclassified | $2.0M | $2.5M |
| 10 | Defiance Lodge 2094 Loyal Order of Moose | Unclassified | $2.0M | $3.4M |
| 11 | Fort Defiance Humane Society INC | Animal-Related | $1.8M | $1.0M |
| 12 | Maumee Valley Planning Organization | Unclassified | $1.7M | $823K |
| 13 | Young Mens Christian Association of Defiance County Ohio | Unclassified | $1.7M | $4.2M |
| 14 | Veterans of Foreign Wars of the United States Department of Ohio | Unclassified | $1.2M | $514K |
| 15 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $1.1M | $2.1M |
| 16 | Benevolent & Protective Order of Elks of the USA | Unclassified | $975K | $316K |
| 17 | Ottawa River Beagle Club INC | Unclassified | $800K | $0 |
| 18 | United Way of Defiance County Incorporated | Unclassified | $705K | $623K |
| 19 | Youth for Christ USA INC | Youth Development | $681K | $511K |
| 20 | Defiance Senior Citizens Housing INC | Housing & Shelter | $636K | $1.7M |
| 21 | Defiance Development and Visitorsbureau INC | Community Improvement & Capacity Building | $589K | $504K |
| 22 | Thoreau Wildlife Reserve INC | Environment | $580K | $1.7M |
| 23 | Defiance Athletic Boosters INC | Unclassified | $448K | $71K |
| 24 | Fischers Feline Rescue LLC | Animal-Related | $437K | $198K |
| 25 | The Defiance Community Cultural Council INC | Arts, Culture & Humanities | $426K | $610K |
| 26 | Ignite Academy | Human Services | $382K | $190K |
| 27 | Childrens Lantern INC | Human Services | $306K | $194K |
| 28 | Defiance Rotary Foundation | Philanthropy, Voluntarism & Grantmaking | $252K | $525K |
| 29 | Defiance Area Chamber of Commerce | Unclassified | $244K | $188K |
| 30 | United Steelworkers | Unclassified | $222K | $375K |
| 31 | Ayersville Athletic Boosters | Education | $199K | $99K |
| 32 | Defiance County Homegrown Workforce & Business Development Council | Community Improvement & Capacity Building | $196K | $10K |
| 33 | Defiance Baseball Association | Recreation & Sports | $175K | $76K |
| 34 | Defiance Optimist Clubc INC | Mutual & Membership Benefit | $157K | $79K |
| 35 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $155K | $275K |
| 36 | Defiance County Historical Society | Unclassified | $150K | $265K |
| 37 | Knights of Columbus | Unclassified | $138K | $257K |
| 38 | Riverview Memory Gardens INC | Mutual & Membership Benefit | $131K | $18K |
| 39 | Defiance Hospital Auxiliary | Health Care | $126K | $235K |
| 40 | Ravens Care INC | Human Services | $117K | $120K |
| 41 | Millard L & Ruth a Searcey Trust Ua 09111992 | Education | $115K | $168K |
| 42 | Northwest Ohio Affordable Housing INC | Human Services | $115K | $595K |
| 43 | South Richland Township Volunteer Firemens Association INC | Unclassified | $107K | $97K |
| 44 | Tinora Boosters Club INC | Education | $107K | $146K |
| 45 | Northwest Ohio Dvc INC | Recreation & Sports | $101K | $8K |
| 46 | Defiance Softball Association INC | Recreation & Sports | $99K | $36K |
| 47 | Kavic INC | Public & Societal Benefit | $98K | $174K |
| 48 | Herman Hesselschwardt 758 Marine Corps League Christmas for Kids | Arts, Culture & Humanities | $96K | $51K |
| 49 | Ohio Lactation Consultant Association | Unclassified | $79K | $102K |
| 50 | Elks 147 Charities INC | Philanthropy, Voluntarism & Grantmaking | $74K | $12K |
| 51 | Rotary International | Unclassified | $73K | $45K |
| 52 | This is Hope INC | Health Care | $67K | $8K |
| 53 | Defiance County Senior Services Auxiliary INC | Human Services | $66K | $73K |
| 54 | Conquer Childhood Cancer Now | Human Services | $62K | $189K |
| 55 | Defiance Area Fish and Game Association INC | Recreation & Sports | $55K | $173K |
| 56 | Defiance College Purple and Gold Athletic Club INC | Education | $55K | $869 |
| 57 | Pharaohz | Community Improvement & Capacity Building | $52K | $6K |
| 58 | Defiance Area Chamber of Commerce Foundation INC | Philanthropy, Voluntarism & Grantmaking | $27K | $19K |
| 59 | Keller Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $16K | $203K |
| 60 | Estella Carl & Clarence Siler Trust 20SI0400 Fbo | Philanthropy, Voluntarism & Grantmaking | $15K | $37K |
| 61 | Defiance City Schools Foundation INC | Unclassified | $11K | $101 |
| 62 | Ayersville Education Foundation | Education | $10K | $1K |
| 63 | Igniting Hope INC | Youth Development | $1 | $1 |
| 64 | Nueva Vida Iglesia Bautista | Unclassified | $0 | $0 |
| 65 | Harc Ministries INC | Religion-Related | $0 | $0 |
| 66 | Ohio Womens Open INC | Philanthropy, Voluntarism & Grantmaking | $0 | $23K |
| 67 | The Ohio State University | Youth Development | $0 | $0 |
| 68 | New Testament Church INC | Unclassified | $0 | $0 |
| 69 | Holy Cross Catholic School of Defiance | Unclassified | $0 | $0 |
| 70 | Marysdale Saint Isidore Parish | Unclassified | $0 | $0 |
| 71 | The Disciple House | Unclassified | $0 | $0 |
| 72 | The Ohio State University | Youth Development | $0 | $0 |
| 73 | Alpha Zeta Omega Pharmaceutical Fraternity | Unclassified | $0 | $0 |
| 74 | Home Builders Association of Northwestern Ohio | Unclassified | $0 | $0 |
| 75 | Northeastern Local Teachers Association | Unclassified | $0 | $0 |
| 76 | Free & Accepted Masons of Ohio | Unclassified | $0 | $0 |
| 77 | American Federation of State County & Municipal Employees | Unclassified | $0 | $0 |
| 78 | Free & Accepted Masons of Ohio | Unclassified | $0 | $0 |
| 79 | Fraternal Order of Eagles | Unclassified | $0 | $0 |
| 80 | The Ohio State University | Youth Development | $0 | $0 |
| 81 | The Ohio State University | Youth Development | $0 | $0 |
| 82 | Defiance High School After Prom | Youth Development | $0 | $0 |
| 83 | The Ohio State University | Youth Development | $0 | $0 |
| 84 | Greater Northwest Ohio Aquatic Conference | Recreation & Sports | $0 | $0 |
| 85 | Forever Family Ministries | Human Services | $0 | $0 |
| 86 | The Ohio State University | Youth Development | $0 | $0 |
| 87 | Defiance Police Department Auxiliary | Crime & Legal-Related | $0 | $0 |
| 88 | Citizens in Action | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 89 | Defiance County Chapter of the Ohio Genealogical Society | Unclassified | $0 | $0 |
| 90 | The Ohio State University | Youth Development | $0 | $0 |
| 91 | Northwest Ohio Jr Golf Assn. | Recreation & Sports | $0 | $0 |
| 92 | Vietnam Veterans of America INC | Public & Societal Benefit | $0 | $0 |
| 93 | Friends of Worthington Cemetery | Arts, Culture & Humanities | $0 | $0 |
| 94 | Blood Wellness Foundation INC | Health Care | $0 | $0 |
| 95 | St. Michael the Archangel Parish | Unclassified | $0 | $0 |
| 96 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $0 | $0 |
| 97 | First Church of God | Unclassified | $0 | $0 |
| 98 | Ayersville Music Boosters | Education | $0 | $0 |
| 99 | Defiance Chapter 1246 Women of the Moose | Unclassified | $0 | $0 |
| 100 | Second Baptist Church Defiance | Unclassified | $0 | $0 |