| 1 | The Cleveland Clinic Foundation | Health Care | $10.8B | $17.4B |
| 2 | Case Western Reserve University | Education | $2.6B | $4.5B |
| 3 | Cleveland Foundation | Philanthropy, Voluntarism & Grantmaking | $1.4B | $3.3B |
| 4 | Jack Joseph and Morton Mandel Supporting Foundation | Philanthropy, Voluntarism & Grantmaking | $760.4M | $3.2B |
| 5 | Southwest General Health Center | Health Care | $541.1M | $523.6M |
| 6 | Jack Joseph and Morton Mandel Foundation | Philanthropy, Voluntarism & Grantmaking | $401.8M | $3.6B |
| 7 | Cleveland Museum of Art | Arts, Culture & Humanities | $400.9M | $1.4B |
| 8 | Cleveland-cliffs Steel LLC Veba Trust | Mutual & Membership Benefit | $280.7M | $456.9M |
| 9 | The Musical Arts Association | Arts, Culture & Humanities | $211.3M | $390.7M |
| 10 | Jewish Federation of Cleveland | Philanthropy, Voluntarism & Grantmaking | $172.6M | $597.8M |
| 11 | Gateway Economic Development Corporation of Greater Cleveland | Community Improvement & Capacity Building | $162.8M | $591.3M |
| 12 | George Gund Foundation | Unclassified | $156.1M | $555.9M |
| 13 | First Catholic Slovak Ladies Assoc of the USA | Unclassified | $140.5M | $1.1B |
| 14 | Catholic Community Foundation | Unclassified | $130.4M | $223.5M |
| 15 | Greater Cleveland Food Bank INC | Food, Agriculture & Nutrition | $128.9M | $160.1M |
| 16 | Western Reserve Area Agency on Aging | Human Services | $127.4M | $46.4M |
| 17 | Hospice of the Western Reserve INC | Human Services | $112.8M | $132.6M |
| 18 | Rock and Roll Hall of Fame and Museum INC | Arts, Culture & Humanities | $112.2M | $279.3M |
| 19 | Howley Foundation Ua 05192016 | Philanthropy, Voluntarism & Grantmaking | $111.9M | $131.9M |
| 20 | Saint Lukes Foundation of Cleveland Ohio | Health Care | $110.9M | $207.1M |
| 21 | Ideastream | Youth Development | $92.5M | $86.3M |
| 22 | United Church Insurance Association | Mutual & Membership Benefit | $87.8M | $33.6M |
| 23 | John Huntington Art & Polytechnic Tr | Arts, Culture & Humanities | $86.3M | $143.4M |
| 24 | Playhouse Square Foundation | Arts, Culture & Humanities | $83.3M | $346.4M |
| 25 | Mid-american Athletic Conference | Unclassified | $77.7M | $15.2M |
| 26 | Catholic Charities Corporation | Human Services | $66.8M | $70.6M |
| 27 | United Church Insurance Company INC | Mutual & Membership Benefit | $61.1M | $60.8M |
| 28 | Cleveland Institute of Music | Education | $60.9M | $152.9M |
| 29 | Cleveland Institute of Art | Education | $59.2M | $123.4M |
| 30 | Chn Housing Partners | Housing & Shelter | $58.0M | $85.1M |
| 31 | Cuyahoga County Convention Facilities Development Corporation | Arts, Culture & Humanities | $57.4M | $20.6M |
| 32 | Emerald Development and Economic | Housing & Shelter | $56.3M | $59.6M |
| 33 | William J & Dorothy K Oneill Foundation INC | Unclassified | $53.9M | $103.6M |
| 34 | The McGregor Foundation | Unclassified | $52.4M | $136.3M |
| 35 | Judson Foundation | Philanthropy, Voluntarism & Grantmaking | $51.4M | $39.0M |
| 36 | Circle Health Services | Unclassified | $50.2M | $26.2M |
| 37 | International Brotherhood of Electrical Workers Local 38 Health | Unclassified | $49.0M | $26.0M |
| 38 | St. Augustine Manor | Human Services | $48.5M | $38.3M |
| 39 | Stepforward | Human Services | $44.2M | $26.4M |
| 40 | Medical Center Company | Public & Societal Benefit | $44.0M | $122.0M |
| 41 | Positive Education Program | Mental Health & Crisis Intervention | $43.8M | $37.2M |
| 42 | Cleveland State University Foundation | Education | $43.7M | $164.7M |
| 43 | International Union of Operating Engineers 18 | Unclassified | $43.7M | $108.9M |
| 44 | United States Catholic Conference | Religion-Related | $42.3M | $89.6M |
| 45 | Cleveland Museum of Natural History | Arts, Culture & Humanities | $41.6M | $405.0M |
| 46 | Imagine Schools INC | Education | $40.2M | $126.7M |
| 47 | United States Catholic Conference | Religion-Related | $40.0M | $85.9M |
| 48 | Lifebanc | Unclassified | $39.3M | $56.1M |
| 49 | YMCA of Greater Cleveland | Human Services | $38.1M | $52.4M |
| 50 | Southwest General Medical Group INC | Health Care | $37.7M | $19.0M |
| 51 | Metrohealth Foundation INC | Health Care | $35.7M | $97.9M |
| 52 | Pipe Fitters-120 Insurance Fund | Unclassified | $35.0M | $34.4M |
| 53 | Hospice of the Western Reserve at University Hospitals LLC | Unclassified | $34.9M | $7.4M |
| 54 | Helen C Cole Tr | Philanthropy, Voluntarism & Grantmaking | $33.8M | $24.7M |
| 55 | Judson | Human Services | $32.5M | $68.3M |
| 56 | Healthnetwork Foundation | Human Services | $30.4M | $73.0M |
| 57 | Neighborhood Health Care Incorporated | Health Care | $30.3M | $22.5M |
| 58 | College Now Greater Cleveland INC | Education | $30.0M | $37.4M |
| 59 | Mental Health Services for Homeless Persons INC | Human Services | $28.8M | $11.5M |
| 60 | Jumpstart INC | Community Improvement & Capacity Building | $28.6M | $86.3M |
| 61 | Keybank Foundation | Unclassified | $28.5M | $151K |
| 62 | Samuel H and Maria Miller Foundation | Unclassified | $28.4M | $119.4M |
| 63 | The Convention and Visitors Bureau of Greater Cleveland INC | Unclassified | $28.2M | $39.7M |
| 64 | Reliabilityfirst Corporation | Public & Societal Benefit | $28.2M | $21.3M |
| 65 | Northeast Ohio Neighborhood Health Services INC | Unclassified | $28.0M | $28.9M |
| 66 | Deluxe Corporation Foundation | Unclassified | $27.4M | $24.7M |
| 67 | Center for Families and Children | Human Services | $27.3M | $45.3M |
| 68 | Government Employees Association INC | Unclassified | $26.6M | $5.3M |
| 69 | Joseph & Florence Mandel Family Foundation - Weinberg Family Fund | Philanthropy, Voluntarism & Grantmaking | $25.9M | $164.7M |
| 70 | United States Catholic Conference | Religion-Related | $25.8M | $54.9M |
| 71 | Progressive Insurance Foundation | Philanthropy, Voluntarism & Grantmaking | $25.5M | $1.3M |
| 72 | Mt Sinai Health Care Foundation | Health Care | $24.8M | $189.5M |
| 73 | Western Reserve Revitalization & Management Co | Housing & Shelter | $24.5M | $88.4M |
| 74 | The@joseph and Florence Mandel Family Foundation-michele M and | Philanthropy, Voluntarism & Grantmaking | $24.1M | $164.9M |
| 75 | Reinberger Foundation | Unclassified | $23.7M | $60.8M |
| 76 | Building Laborers Local 310 Health & Welfare Fund | Unclassified | $23.7M | $10.9M |
| 77 | Euclid Avenue Development Corporation | Education | $23.2M | $221.3M |
| 78 | Case Alumni Foundation | Philanthropy, Voluntarism & Grantmaking | $23.2M | $90.6M |
| 79 | Legal Aid Society of Cleveland | Unclassified | $23.0M | $22.5M |
| 80 | Murtis Taylor Human Services System | Mental Health & Crisis Intervention | $22.5M | $9.3M |
| 81 | United Way of Greater Cleveland Fund | Philanthropy, Voluntarism & Grantmaking | $22.4M | $44.8M |
| 82 | Connor Foundation | Philanthropy, Voluntarism & Grantmaking | $22.3M | $41.1M |
| 83 | Higley Fund of the Cleveland Foundation | Unclassified | $22.2M | $44.3M |
| 84 | Saint Martin de Porres High School | Education | $22.1M | $37.7M |
| 85 | Empire-tolden-united Taconile-hibbing Post-2014 Retiree | Mutual & Membership Benefit | $21.2M | $26.6M |
| 86 | South Franklin Circle | Human Services | $21.2M | $104.3M |
| 87 | Painting Industry Insurance Fund | Unclassified | $21.1M | $14.1M |
| 88 | Roger J Trinchero Family Foundation | Philanthropy, Voluntarism & Grantmaking | $20.7M | $16.9M |
| 89 | Manufacturing Advocacy & Growth Network INC | Community Improvement & Capacity Building | $20.6M | $21.3M |
| 90 | Urban Community School | Unclassified | $20.6M | $71.4M |
| 91 | David and Inez Myers Foundation | Philanthropy, Voluntarism & Grantmaking | $20.5M | $247.9M |
| 92 | Digitalc | Community Improvement & Capacity Building | $20.3M | $22.6M |
| 93 | 151 Firefighters Community Credit Union INC | Unclassified | $20.3M | $343.9M |
| 94 | Western Reserve Care Solutions | Health Care | $18.7M | $15.7M |
| 95 | Joan C Edwards Charitable Foudation | Philanthropy, Voluntarism & Grantmaking | $18.5M | $29.1M |
| 96 | Greater Cleveland Partnership | Community Improvement & Capacity Building | $18.4M | $32.0M |
| 97 | American Foundation Corporation | Unclassified | $18.2M | $23.1M |
| 98 | Friends of Breakthrough Schools | Education | $18.1M | $126.1M |
| 99 | Cleveland Society for the Blind | Human Services | $18.0M | $162.1M |
| 100 | Habitat for Humanity International INC | Housing & Shelter | $17.9M | $30.0M |