| 1 | Childrens Hospital Medical Center | Health Care | $4.6B | $10.0B |
| 2 | Uc Healthcare System | Health Care | $2.6B | $1.8B |
| 3 | Bon Secours Richmond Health System | Health Care | $2.1B | $0 |
| 4 | Christ Hospital | Health Care | $1.4B | $1.4B |
| 5 | Kroger Co Health and Welfare Benefit Tr for Collectively-bargai | Unclassified | $1.2B | $0 |
| 6 | Bethesda Hospital INC | Health Care | $1.1B | $1.3B |
| 7 | The Good Samaritan Hospital of Cincinnati Ohio Dtd 01251995 | Health Care | $983.3M | $1.2B |
| 8 | Xavier University | Education | $638.8M | $796.7M |
| 9 | Childrens Hospital | Health Care | $625.3M | $5.4B |
| 10 | Southern Ohio Chamber Alliance Benefit Plan | Mutual & Membership Benefit | $556.4M | $61.4M |
| 11 | 1386 General Electric Credit Union | Unclassified | $524.6M | $4.4B |
| 12 | University of Cincinnati Physicians INC | Unclassified | $397.0M | $195.4M |
| 13 | Trihealth INC | Religion-Related | $390.9M | $2.4B |
| 14 | United Way of Greater Cincinnati | Philanthropy, Voluntarism & Grantmaking | $369.9M | $83.0M |
| 15 | Greater Cincinnati Foundation | Philanthropy, Voluntarism & Grantmaking | $355.7M | $1.0B |
| 16 | Trihealth Physician Enterprises Corp. | Health Care | $269.2M | $105.7M |
| 17 | Greenacres Foundation | Environment | $202.4M | $388.2M |
| 18 | University of Cincinnati Foundation | Philanthropy, Voluntarism & Grantmaking | $187.4M | $904.7M |
| 19 | Deaconess Associations INC | Health Care | $178.2M | $1.3B |
| 20 | Trihealth Physician Institute | Health Care | $176.3M | $12.6M |
| 21 | Johnson Charitable Gift Fund | Philanthropy, Voluntarism & Grantmaking | $165.6M | $383.4M |
| 22 | Procter & Gamble Company Retiree Benefit Tr | Unclassified | $153.3M | $12.3M |
| 23 | Millstone Fund | Philanthropy, Voluntarism & Grantmaking | $153.0M | $235.1M |
| 24 | Procter & Gamble Benefit Plan Trust | Unclassified | $126.4M | $79.1M |
| 25 | Farmer Family Foundation | Unclassified | $125.2M | $242.2M |
| 26 | Cincinnati Symphony Orchestra | Arts, Culture & Humanities | $119.9M | $377.8M |
| 27 | Elizabeth Gamble Deaconess Home Association | Health Care | $110.0M | $1.7B |
| 28 | American Financial Group INC Voluntary Employees Beneficiary Tr | Unclassified | $102.5M | $38.3M |
| 29 | Freestore-foodbank INC | Food, Agriculture & Nutrition | $95.1M | $72.6M |
| 30 | Mount St. Joseph University | Education | $88.9M | $125.3M |
| 31 | Childrens Home of Cincinnati Ohio INC | Human Services | $88.8M | $55.4M |
| 32 | Music and Event Management INC | Arts, Culture & Humanities | $87.4M | $37.0M |
| 33 | Talbert House | Human Services | $84.6M | $38.1M |
| 34 | Robert and Adele Schiff Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $84.5M | $223.3M |
| 35 | Hospice of Cincinnati Incorporated | Unclassified | $81.5M | $103.5M |
| 36 | Bayley Senior Care | Human Services | $78.9M | $143.8M |
| 37 | Young Mens Christian Association of Greater Cincinnati | Philanthropy, Voluntarism & Grantmaking | $73.3M | $102.0M |
| 38 | Ohio Valley Goodwill Industries Rehabilitation Center INC | Unclassified | $72.9M | $101.6M |
| 39 | Zoological Society of Cincinnati | Animal-Related | $70.1M | $330.4M |
| 40 | Cincinnati Center City Development Corporation | Community Improvement & Capacity Building | $65.7M | $456.4M |
| 41 | Bethesda Foundation INC | Health Care | $62.9M | $181.8M |
| 42 | John J & Mary R Schiff Foundation | Unclassified | $62.0M | $176.6M |
| 43 | Western and Southern Life Insurance Company Veba Trust | Unclassified | $55.6M | $9.0M |
| 44 | Maple Knoll Communities INC | Human Services | $55.5M | $156.6M |
| 45 | Cincinnati Hills Christian Academy INC | Education | $54.4M | $110.4M |
| 46 | McCullough-hyde Memorial Hospital Incorporated | Health Care | $54.3M | $56.0M |
| 47 | Bethesda INC | Health Care | $51.8M | $215.3M |
| 48 | Scripps-howard Foundation | Philanthropy, Voluntarism & Grantmaking | $51.5M | $69.4M |
| 49 | The Seven Hills Schools | Education | $49.8M | $135.1M |
| 50 | Cincinnati Institute of Fine Arts | Arts, Culture & Humanities | $44.4M | $137.7M |
| 51 | The Frances R Luther Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $44.3M | $53.1M |
| 52 | Joanie C Bernard Foundation | Animal-Related | $44.2M | $81.1M |
| 53 | Twin Towers | Human Services | $43.5M | $86.9M |
| 54 | Lighthouse Youth Services INC | Human Services | $43.2M | $10.4M |
| 55 | Episcopal Retirement Homes INC | Human Services | $42.8M | $62.0M |
| 56 | Dynamic Catholic Institute | Religion-Related | $40.0M | $47.9M |
| 57 | Cincinnati-hamilton County Community Action Agency | Human Services | $39.5M | $15.0M |
| 58 | Pipe Fitters Union Health and Welfare Fund Local 392 | Mutual & Membership Benefit | $38.9M | $39.8M |
| 59 | Cincinnati Museum Association | Arts, Culture & Humanities | $38.0M | $300.5M |
| 60 | Spring Grove Cemetery and Arboretum | Unclassified | $37.8M | $197.7M |
| 61 | Strategies to End Homelessness INC | Human Services | $36.3M | $12.9M |
| 62 | Jewish Federation of Cincinnati | Philanthropy, Voluntarism & Grantmaking | $36.2M | $192.4M |
| 63 | Ronald McDonald House Charities of Greater Cincinnati | Human Services | $35.4M | $98.3M |
| 64 | Samir M Shafie Charitable Foundation C-u Dec of Trust | Human Services | $34.8M | $17.9M |
| 65 | Cincinnati USA Regional Chamber | Unclassified | $33.8M | $20.9M |
| 66 | Cincinnati Association for the Blind | Human Services | $33.7M | $39.9M |
| 67 | Cincinnati Museum Center | Arts, Culture & Humanities | $33.4M | $340.8M |
| 68 | Jacob G Schmidlapp Tr Uw | Unclassified | $33.2M | $56.9M |
| 69 | Ohio Shared Information Services INC | Philanthropy, Voluntarism & Grantmaking | $33.1M | $11.2M |
| 70 | Interact for Health | Unclassified | $32.7M | $262.5M |
| 71 | Ronald and Florence Koetters Foundation | Philanthropy, Voluntarism & Grantmaking | $32.2M | $30.8M |
| 72 | Cincinnati Country Day School | Education | $31.0M | $37.7M |
| 73 | Strivetogether INC | Philanthropy, Voluntarism & Grantmaking | $30.3M | $10.9M |
| 74 | C C D S Foundation | Unclassified | $29.9M | $38.2M |
| 75 | Kwi | Philanthropy, Voluntarism & Grantmaking | $29.3M | $116.0M |
| 76 | Austin E Knowlton Foundation INC | Unclassified | $28.7M | $266.5M |
| 77 | Carol Ann and Ralph V Haile Jr Foundation | Philanthropy, Voluntarism & Grantmaking | $28.6M | $283.2M |
| 78 | St. Vincent Depaul Stores | Human Services | $28.1M | $17.3M |
| 79 | Convalescent Hospital Fund for Children | Health Care | $27.6M | $212.0M |
| 80 | Clovernook Center for the Blind and Visually Impaired | Human Services | $27.4M | $37.4M |
| 81 | Sharefax Credit Union INC | Unclassified | $26.6M | $507.3M |
| 82 | St. Joseph Infant & Maternity Home | Human Services | $26.5M | $61.0M |
| 83 | Sjo Kids INC | Human Services | $26.5M | $26.6M |
| 84 | Bethesda Healthcare INC | Health Care | $25.8M | $18.7M |
| 85 | International Brotherhood of Teamsters Iap Local 2750 | Unclassified | $25.3M | $17.3M |
| 86 | Cincinnati Arts Association | Arts, Culture & Humanities | $25.0M | $67.3M |
| 87 | Edelweiss Foundation | Philanthropy, Voluntarism & Grantmaking | $25.0M | $55.6M |
| 88 | Kenwood Country Club | Unclassified | $24.9M | $27.3M |
| 89 | Beech Acres Parenting Center | Human Services | $24.8M | $81.6M |
| 90 | Child Focus INC | Human Services | $24.7M | $13.1M |
| 91 | Ena Incorporated | Human Services | $24.3M | $26.1M |
| 92 | Greater Cincinnati Convention & Visitors Bureau INC | Unclassified | $24.2M | $20.6M |
| 93 | Unnewehr Family Foundation | Philanthropy, Voluntarism & Grantmaking | $24.2M | $55.4M |
| 94 | Charles H Dater Foundation INC | Unclassified | $24.0M | $101.0M |
| 95 | Seton Education Partners | Philanthropy, Voluntarism & Grantmaking | $23.7M | $130.9M |
| 96 | Beechwood Foundation | Health Care | $23.5M | $43.3M |
| 97 | Chmc Community Health Services Network | Health Care | $23.5M | $12.0M |
| 98 | Gillette Company Employee Benefit Trust | Unclassified | $23.2M | $85.0M |
| 99 | Society of St. Vincent Depaul Particular Council of Cinti | Human Services | $22.7M | $32.4M |
| 100 | Cincinnati Development Fund INC | Housing & Shelter | $22.3M | $101.6M |