| 1 | A Mainehealth Hcsr | Health Care | $4.9B | $4.2B |
| 2 | Martins Point Generations Advantage INC | Health Care | $763.4M | $221.8M |
| 3 | Martins Point Health Care INC | Health Care | $596.6M | $575.9M |
| 4 | Mercy Hospital | Health Care | $329.2M | $259.7M |
| 5 | Harold Alfond Foundation | Philanthropy, Voluntarism & Grantmaking | $191.7M | $1.0B |
| 6 | Maine Guaranteed Access Reinsurance Association | Health Care | $176.5M | $87.0M |
| 7 | Spurwink Services Incorporated | Unclassified | $98.0M | $51.6M |
| 8 | John T Gorman Foundation | Philanthropy, Voluntarism & Grantmaking | $70.0M | $223.5M |
| 9 | Mainhealth Services | Health Care | $46.1M | $365.8M |
| 10 | Libra Foundation Owen W Wells Trustee | Unclassified | $41.4M | $161.6M |
| 11 | Shalom House | Mental Health & Crisis Intervention | $39.1M | $20.2M |
| 12 | Lunder Foundation | Unclassified | $37.6M | $818K |
| 13 | Evergreen Credit Union | Unclassified | $33.2M | $569.2M |
| 14 | Catholic Charities Maine | Human Services | $31.5M | $22.4M |
| 15 | Preble Street | Human Services | $30.6M | $36.9M |
| 16 | Maine College of Art | Education | $30.4M | $49.9M |
| 17 | Waynflete School | Education | $30.2M | $70.8M |
| 18 | University of Southern Maine Foundation | Philanthropy, Voluntarism & Grantmaking | $27.8M | $58.6M |
| 19 | Td Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $27.3M | $9.0M |
| 20 | Onpoint Health Data | Health Care | $25.4M | $29.7M |
| 21 | Morton-kelly Charitable Tr | Unclassified | $24.7M | $20.2M |
| 22 | Maine Technology Institute | Education | $22.5M | $29.2M |
| 23 | Gulf of Maine Research Institute | Animal-Related | $22.5M | $53.7M |
| 24 | Saint Josephs Manor | Health Care | $22.3M | $6.5M |
| 25 | Jha Services INC | Unclassified | $19.0M | $17.3M |
| 26 | Catholic Foundation of Maine | Religion-Related | $16.8M | $40.4M |
| 27 | Evernorth | Housing & Shelter | $16.7M | $26.0M |
| 28 | Portland Museum of Art | Arts, Culture & Humanities | $15.1M | $96.1M |
| 29 | J Blair and Tena Frank Foundation | Philanthropy, Voluntarism & Grantmaking | $14.8M | $30.4M |
| 30 | Community Housing of Maine INC | Housing & Shelter | $14.6M | $51.3M |
| 31 | Cedars Nursing Care Center INC | Health Care | $14.5M | $53.1M |
| 32 | Seventy-five State Street | Housing & Shelter | $14.4M | $26.6M |
| 33 | American Schools Abroad INC | Unclassified | $13.9M | $18.0M |
| 34 | Avesta Housing Development Corporation | Housing & Shelter | $13.5M | $82.7M |
| 35 | Pine Tree Legal Assistance INC | Crime & Legal-Related | $13.1M | $10.2M |
| 36 | Jha Assisted Living INC | Housing & Shelter | $12.2M | $18.5M |
| 37 | United Way INC | Philanthropy, Voluntarism & Grantmaking | $11.5M | $20.2M |
| 38 | Home for the Aged | Human Services | $10.9M | $32.8M |
| 39 | Avesta Housing Management Corporation | Housing & Shelter | $10.9M | $5.4M |
| 40 | Schiavi Family Foundation | Unclassified | $10.7M | $35.0M |
| 41 | Boys & Girls Clubs of Southern Maine | Youth Development | $10.6M | $27.1M |
| 42 | Reverb INC | Environment | $9.8M | $8.4M |
| 43 | Evernorth Loan Fund INC | Housing & Shelter | $9.7M | $28.1M |
| 44 | Milestone Recovery | Mental Health & Crisis Intervention | $9.4M | $5.9M |
| 45 | Portland Public Library | Education | $8.8M | $17.3M |
| 46 | Usm Osher Map Library Foundation | Unclassified | $8.8M | $14.5M |
| 47 | Biodiversity | Environment | $8.2M | $5.0M |
| 48 | Maine Historical Society | Arts, Culture & Humanities | $8.1M | $15.0M |
| 49 | Community Dental | Health Care | $7.8M | $6.3M |
| 50 | Sam L Cohen Foundation | Philanthropy, Voluntarism & Grantmaking | $7.2M | $28.2M |
| 51 | Alfond Scholarship Foundation | Education | $7.2M | $1.7M |
| 52 | Bangor Theological Seminary | Religion-Related | $6.9M | $22.4M |
| 53 | Pine Tree Housing Agency | Philanthropy, Voluntarism & Grantmaking | $6.7M | $7.6M |
| 54 | Great Schools Partnership INC | Education | $6.6M | $1.9M |
| 55 | Jewish Community Alliance of Southern Maine | Philanthropy, Voluntarism & Grantmaking | $6.4M | $13.3M |
| 56 | Mmc Realty Corp. | Health Care | $6.3M | $52.9M |
| 57 | Portland Maine Symphony Orchestra | Arts, Culture & Humanities | $6.0M | $16.9M |
| 58 | Young Mens Christian Association of Southern Maine | Unclassified | $5.8M | $15.0M |
| 59 | Maine Peoples Resource Center | Unclassified | $5.8M | $3.6M |
| 60 | Senator George J Mitchell Scholarship Research Institute | Education | $5.7M | $53.2M |
| 61 | Portland Housing Development Corporation | Unclassified | $5.6M | $24.2M |
| 62 | Frannie Peabody Center INC | Unclassified | $5.5M | $6.0M |
| 63 | Maine Pretrial Services INC | Unclassified | $5.5M | $1.9M |
| 64 | Maine Needs INC | Human Services | $5.4M | $1.1M |
| 65 | Roxanne Quimby Foundation INC | Philanthropy, Voluntarism & Grantmaking | $5.3M | $28.8M |
| 66 | State Street Housing Preservation Corporation | Housing & Shelter | $5.3M | $20.8M |
| 67 | Quimby Family Foundation | Philanthropy, Voluntarism & Grantmaking | $5.1M | $21.5M |
| 68 | Breakwater Learning | Education | $5.1M | $5.7M |
| 69 | Habitat for Humanity of Greater Portland INC | Unclassified | $5.1M | $6.3M |
| 70 | Pan Atlantic Foundation | International, Foreign Affairs & National Security | $4.9M | $3.1M |
| 71 | Margaret Chase Smith Foundation | Philanthropy, Voluntarism & Grantmaking | $4.8M | $16.6M |
| 72 | Baxter Academies of Maine | Education | $4.8M | $8.0M |
| 73 | October Corporation | Community Improvement & Capacity Building | $4.6M | $56.5M |
| 74 | The Bill and Joan Alfond Foundation | Unclassified | $4.5M | $31.2M |
| 75 | Maine Humanities Council | Arts, Culture & Humanities | $4.1M | $4.5M |
| 76 | Portland Stage Company INC | Arts, Culture & Humanities | $3.8M | $9.2M |
| 77 | Childrens Odyssey | Education | $3.8M | $601K |
| 78 | Iris Network | Unclassified | $3.6M | $10.4M |
| 79 | Educate Maine | Education | $3.6M | $1.8M |
| 80 | Commonspace | Health Care | $3.6M | $1.4M |
| 81 | Maple Grove Elderly Housing Corporation | Housing & Shelter | $3.4M | $15.1M |
| 82 | Childrens Museum and Theatre of Maine | Arts, Culture & Humanities | $3.4M | $14.7M |
| 83 | Indigo Arts Alliance | Arts, Culture & Humanities | $3.4M | $4.4M |
| 84 | Moser Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.3M | $6.9M |
| 85 | Immigrant Legal Advocacy Project | Crime & Legal-Related | $3.3M | $2.0M |
| 86 | Safe Passage | International, Foreign Affairs & National Security | $3.3M | $3.4M |
| 87 | Portland Ovations | Arts, Culture & Humanities | $3.3M | $3.9M |
| 88 | Olympia Snowe Womens Leadership Ins | Human Services | $3.2M | $9.1M |
| 89 | Institute for Doctoral Studies Inthe Visual Arts | Education | $3.1M | $2.5M |
| 90 | Prosperityme | Human Services | $3.1M | $5.1M |
| 91 | Through These Doors | Human Services | $3.1M | $2.5M |
| 92 | Ancient Accepted Scottish Rite of Free Masonry Nmj | Unclassified | $3.0M | $7.7M |
| 93 | Diocesan Bureau of Housing Deering Pavilion | Housing & Shelter | $2.9M | $9.3M |
| 94 | Womens Board of the Maine Medical Center | Unclassified | $2.9M | $911K |
| 95 | General E R Quesada Educational | Education | $2.8M | $5.2M |
| 96 | Center for Regional Prosperity | Human Services | $2.8M | $193K |
| 97 | Friends of Katahdin Woods and Waters | Arts, Culture & Humanities | $2.8M | $1.6M |
| 98 | Learning Works | Human Services | $2.8M | $1.8M |
| 99 | American Civil Liberties Union of Maine Foundation | Civil Rights, Social Action & Advocacy | $2.8M | $7.7M |
| 100 | Maine Immigrants Rights Coalition | Human Services | $2.6M | $969K |