| 1 | Parkview Hospital INC | Health Care | $2.1B | $1.2B |
| 2 | Parkview Health System INC | Health Care | $1.8B | $2.5B |
| 3 | Foellinger Foundation INC | Unclassified | $442.4M | $252.3M |
| 4 | Physicians Health Plan of Northern Indiana INC | Unclassified | $200.2M | $78.0M |
| 5 | Indiana Institute of Technology INC | Education | $190.6M | $347.8M |
| 6 | University of Saint Francis of Fort Wayne Indiana INC | Education | $113.6M | $122.8M |
| 7 | Community Foundation of Greater Fort Wayne INC | Philanthropy, Voluntarism & Grantmaking | $70.6M | $245.4M |
| 8 | Anthony Wayne Rehabilitation Center for Handicapped & Blind | Health Care | $61.5M | $43.0M |
| 9 | Lutheran Homes INC | Human Services | $54.7M | $85.9M |
| 10 | Surack Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $50.8M | $47.5M |
| 11 | Park Center INC | Mental Health & Crisis Intervention | $47.1M | $28.7M |
| 12 | Patricia Schaefer Foundation Tr | Unclassified | $46.3M | $90.8M |
| 13 | Metropolitan Young Mens Christian Association | Human Services | $35.5M | $62.5M |
| 14 | 8020 Foundation Tr | Philanthropy, Voluntarism & Grantmaking | $35.1M | $240.6M |
| 15 | Lifeline Youth & Family Services INC | Human Services | $34.6M | $29.9M |
| 16 | The Arc of Northeast Indiana INC | Human Services | $33.4M | $29.3M |
| 17 | Community Action of Northeast Indiana INC | Community Improvement & Capacity Building | $32.2M | $20.1M |
| 18 | Community Harvest Food Bank of Northeast Indiana INC | Food, Agriculture & Nutrition | $30.1M | $16.6M |
| 19 | Fort Wayne Zoological Society INC | Animal-Related | $28.7M | $40.1M |
| 20 | Olive B Cole Foundation INC | Unclassified | $26.8M | $32.4M |
| 21 | Neighborhood Health Clinics INC | Health Care | $24.3M | $31.5M |
| 22 | Fort Wayne Philharmonic Orchestra INC | Arts, Culture & Humanities | $23.6M | $40.0M |
| 23 | Plumbers & Steamfitters Local 166 Health & Welfare Pl | Unclassified | $22.9M | $33.7M |
| 24 | Lasting Change INC | Crime & Legal-Related | $22.2M | $42.1M |
| 25 | Visiting Nurse and Hospice Home INC | Health Care | $21.4M | $29.0M |
| 26 | Aws Foundation INC | Human Services | $21.0M | $115.8M |
| 27 | Goodwill Industries of Northeast Indiana INC | Employment | $20.8M | $9.5M |
| 28 | Canterbury School INC | Education | $19.4M | $36.7M |
| 29 | Aging and In-home Services of Ne in | Human Services | $18.9M | $7.3M |
| 30 | McMillen Foundation INC | Unclassified | $17.6M | $29.2M |
| 31 | Concordia Education Foundation INC | Education | $17.5M | $27.9M |
| 32 | Golden Years Homestead INC | Health Care | $17.5M | $49.7M |
| 33 | Jobworks INC | Employment | $16.0M | $4.3M |
| 34 | Trinity English Evangelical Lutheran Church Foundation INC | Religion-Related | $15.5M | $11.5M |
| 35 | Parkview Health Foundation INC | Health Care | $15.0M | $37.3M |
| 36 | Ardelle and Theresa Glaze Foundation | Philanthropy, Voluntarism & Grantmaking | $14.8M | $42.2M |
| 37 | Mary Cross Tippmann Foundation Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $14.6M | $187.7M |
| 38 | Iris Family Support Center INC | Human Services | $14.2M | $9.6M |
| 39 | Recovery Health Services INC | Health Care | $13.8M | $34.7M |
| 40 | Pearl Arts INC | Arts, Culture & Humanities | $13.3M | $39.8M |
| 41 | Arts United of Greater Fort Wayne | Arts, Culture & Humanities | $13.2M | $51.4M |
| 42 | Turnstone Center for Children and Adults with Disabilities INC | Health Care | $12.9M | $27.4M |
| 43 | The Len-ari Foundation INC | Philanthropy, Voluntarism & Grantmaking | $11.8M | $18.4M |
| 44 | Steel Dynamics Foundation INC | Philanthropy, Voluntarism & Grantmaking | $11.8M | $11.4M |
| 45 | Php Foundation INC | Philanthropy, Voluntarism & Grantmaking | $11.2M | $51.8M |
| 46 | Fort Wayne Country Club | Unclassified | $10.4M | $12.5M |
| 47 | Habitat for Humanity of Greater Fort Wayne INC | Housing & Shelter | $10.4M | $14.5M |
| 48 | Childrens Autism Centerincorporated | Diseases, Disorders & Medical Disciplines | $10.2M | $5.6M |
| 49 | Parkview Occupational Health Centers INC | Health Care | $10.2M | $2.5M |
| 50 | The Fort Wayne Rescue Mission Ministries INC | Housing & Shelter | $9.8M | $17.6M |
| 51 | Matthew 25 INC | Health Care | $9.4M | $8.6M |
| 52 | Catholic Charities of the Diocese of Fort Wayne-south Bend INC | Human Services | $9.3M | $6.7M |
| 53 | Vincent Village INC | Housing & Shelter | $9.1M | $19.4M |
| 54 | Destiny Rescue USA INC | International, Foreign Affairs & National Security | $8.1M | $3.3M |
| 55 | Fort Wayne Medical Society Foundation INC | Health Care | $7.9M | $5.6M |
| 56 | Questa Education Foundation INC | Education | $7.8M | $18.4M |
| 57 | Humane Fort Wayne INC | Animal-Related | $7.7M | $18.2M |
| 58 | Northeast Indian Works INC | Employment | $7.7M | $2.8M |
| 59 | Big Brothers Big Sisters of Northeast Indiana INC | Unclassified | $7.6M | $11.9M |
| 60 | Tim and Libby Ash Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $7.6M | $11.9M |
| 61 | Junior Achievement of Northern Indiana | International, Foreign Affairs & National Security | $7.1M | $9.7M |
| 62 | Crossroad Child & Family Services INC | Unclassified | $6.8M | $14.7M |
| 63 | Brotherhood Mutual Foundation INC | Philanthropy, Voluntarism & Grantmaking | $6.5M | $8K |
| 64 | Lutheran Scholarship Granting Organization of Indiana INC | Philanthropy, Voluntarism & Grantmaking | $6.3M | $8.5M |
| 65 | Rifkin Family Foundation | Unclassified | $6.3M | $11.7M |
| 66 | Fort Wayne Museum of Art INC | Arts, Culture & Humanities | $6.2M | $14.8M |
| 67 | Girl Scouts of Northern Indiana Michiana INC | Youth Development | $6.1M | $12.1M |
| 68 | Healthier Moms and Babies INC | Health Care | $6.0M | $3.1M |
| 69 | YWCA Northeast Indiana INC | Human Services | $5.9M | $10.5M |
| 70 | Timothy L Johnson Academy | Education | $5.7M | $1.9M |
| 71 | Embassy Theatre Foundation INC | Arts, Culture & Humanities | $5.6M | $18.1M |
| 72 | Chapman Charitable Tr Dtd 3-3-17 | Philanthropy, Voluntarism & Grantmaking | $5.6M | $13.3M |
| 73 | Doermer Family Foundation INC | Unclassified | $5.5M | $17.3M |
| 74 | Lutheran Social Services of Indiana INC | Human Services | $5.5M | $7.3M |
| 75 | Marvin and Marva Komisarow Foundation | Philanthropy, Voluntarism & Grantmaking | $5.3M | $1.8M |
| 76 | Boys & Girls Club of Fort Wayne INC | Youth Development | $5.2M | $16.4M |
| 77 | Malpas Trust | Education | $5.1M | $5.2M |
| 78 | Early Childhood Alliance INC | Human Services | $5.0M | $3.9M |
| 79 | William J and Bonnie L Hefner Foundation INC | Philanthropy, Voluntarism & Grantmaking | $5.0M | $20.3M |
| 80 | Allen County Fort Wayne Development Trust INC | Community Improvement & Capacity Building | $4.9M | $118.5M |
| 81 | Allen County Public Library Foundation | Education | $4.9M | $25.4M |
| 82 | Public Service Credit Union | Public & Societal Benefit | $4.8M | $82.2M |
| 83 | Vann Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $4.8M | $12.6M |
| 84 | Junior Achievement of Northern Indiana Foundation INC | Unclassified | $4.6M | $19.7M |
| 85 | Alliance Health Centers INC | Health Care | $4.6M | $5.9M |
| 86 | Fort Wayne Ballet INC | Arts, Culture & Humanities | $4.6M | $2.7M |
| 87 | United Way of Allen County INC | Philanthropy, Voluntarism & Grantmaking | $4.4M | $5.0M |
| 88 | Kevin J and Pamela J Kelly Foundation INC | Unclassified | $4.4M | $5.1M |
| 89 | Leona Z Rosenberg Charitable Trust | Unclassified | $4.3M | $5.0M |
| 90 | Soulmedic Media Group INC | Religion-Related | $4.3M | $8.2M |
| 91 | League for the Blind and Disabled INC | Diseases, Disorders & Medical Disciplines | $4.3M | $14.7M |
| 92 | Fort Wayne Allen County Convention and Visitors Bureau INC | Unclassified | $4.2M | $3.5M |
| 93 | Let Them Live Action Corporation | Human Services | $4.1M | $242K |
| 94 | Fraternal Order of Eagles | Unclassified | $4.0M | $652K |
| 95 | Visiting Nurse and Hospice Home Foundation INC | Health Care | $4.0M | $11.1M |
| 96 | McComb Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.9M | $4.8M |
| 97 | Tom Kelley Buick INC Employees Group Plan 501-C-9 Trust | Unclassified | $3.8M | $2.0M |
| 98 | Super Shot INC | Health Care | $3.8M | $5.8M |
| 99 | Greater Fort Wayne Metro Chamber Alliance INC | Unclassified | $3.8M | $3.6M |
| 100 | Rudolph Family Foundation | Philanthropy, Voluntarism & Grantmaking | $3.5M | $3.2M |