| 1 | University of Notre Dame du Lac Notre Dame | B | $11.3B | $3.3B | $26.7B |
| 2 | Indiana University Health INC Indianapolis | E | $9.5B | $6.1B | $12.8B |
| 3 | Morgan Stanley Global Impact Funding Trust INC Indianapolis | T | $6.9B | $3.1B | $9.1B |
| 4 | Renaissance Charitable Foundation INC Indianapolis | T | $4.6B | $2.4B | $5.9B |
| 5 | Lilly Cares Foundation INC Indianapolis | P | $4.1B | $0 | $1 |
| 6 | Franciscan Alliance INC Mishawaka | E | $3.8B | $3.8B | $6.3B |
| 7 | Lilly Endowment INC Indianapolis | Z | $3.1B | $0 | $79.9B |
| 8 | Community Health Network INC Indianapolis | E | $2.6B | $2.3B | $3.0B |
| 9 | Deaconess Hospital INC Evansville | E | $2.3B | $1.5B | $2.9B |
| 10 | Parkview Hospital INC Fort Wayne | E | $2.1B | $2.1B | $1.2B |
| 11 | Mdwise Medicaid Network INC Indianapolis | E | $1.9B | $1.9B | $308.6M |
| 12 | Parkview Health System INC Fort Wayne | E | $1.8B | $1.2B | $2.5B |
| 13 | Mdwise INC Indianapolis | Z | $1.8B | $1.8B | $686.2M |
| 14 | National Collegiate Athletic Association Indianapolis | N | $1.6B | $1.3B | $1.1B |
| 15 | Community Foundation of Northwest Indiana INC Munster | T | $1.6B | $171.9M | $1.8B |
| 16 | Indiana University Health Care Associates INC Indianapolis | E | $1.4B | $1.4B | $299.9M |
| 17 | Indiana University Foundation Bloomington | B | $1.0B | $447.8M | $4.4B |
| 18 | Culver Educational Foundation Culver | B | $851.8M | $180.4M | $1.1B |
| 19 | Purdue Research Foundation West Lafayette | B | $835.7M | $322.8M | $4.7B |
| 20 | Indiana University Health Bloomingon INC Indianapolis | E | $828.7M | $780.1M | $841.7M |
| 21 | Indianapolis Museum of Art INC Indianapolis | A | $828.4M | $50.7M | $535.8M |
| 22 | Wabash Valley Power Association INC Indianapolis | Z | $806.3M | $805.6M | $1.7B |
| 23 | Indiana University Health Plans Nfp INC Indianapolis | E | $773.9M | $251.0M | $53.4M |
| 24 | Memorial Hospital of South Bend South Bend | E | $749.4M | $746.8M | $678.0M |
| 25 | Union Hospital INC Terre Haute | E | $742.6M | $737.9M | $751.3M |
| 26 | Munster Medical Research Foundation INC Munster | E | $729.1M | $729.0M | $330.9M |
| 27 | Indiana University Health Arnett INC Indianapolis | E | $662.1M | $662.0M | $374.4M |
| 28 | Lumina Foundation for Education INC Indianapolis | T | $644.8M | $0 | $1.5B |
| 29 | Midcontinent Independent System Operator INC Carmel | W | $616.4M | $616.1M | $3.4B |
| 30 | Reid Hospital & Health Care Services INC Richmond | E | $595.5M | $594.2M | $1.7B |
| 31 | Indiana University Health Ball Memorial Hospital INC Indianapolis | E | $585.4M | $581.0M | $731.9M |
| 32 | Beacon Health System INC South Bend | E | $562.4M | $302.4M | $1.3B |
| 33 | Strada Education Foundation INC Indianapolis | S | $557.8M | $207.7M | $1.8B |
| 34 | The Methodist Hospitals INC Gary | E | $544.0M | $493.4M | $364.8M |
| 35 | Indiana University Health North Hospital INC Indianapolis | E | $524.0M | $524.0M | $1.0B |
| 36 | The Lutheran University Association INC Valparaiso | B | $445.2M | $167.3M | $602.9M |
| 37 | Goshen Hospital Association INC Goshen | E | $443.6M | $284.1M | $412.9M |
| 38 | Foellinger Foundation INC Fort Wayne | Z | $442.4M | $0 | $252.3M |
| 39 | Community Physicians of Indiana INC Indianapolis | E | $429.1M | $428.5M | $100.2M |
| 40 | Butler University Indianapolis | B | $412.7M | $320.7M | $756.2M |
| 41 | Deaconess Health System INC Evansville | E | $398.1M | $398.1M | $691.4M |
| 42 | Elkhart General Hospital INC Elkhart | E | $395.6M | $395.2M | $269.1M |
| 43 | Indiana University Health West Hospital INC Indianapolis | E | $392.8M | $392.8M | $793.3M |
| 44 | Saint Joseph Regional Medical Center-south Bend Campus INC Mishawaka | E | $388.0M | $387.9M | $1.3B |
| 45 | Wabash College Crawfordsville | B | $384.3M | $111.0M | $633.2M |
| 46 | St. Mary Medical Center INC Munster | E | $378.8M | $378.4M | $211.7M |
| 47 | Depauw University Greencastle | B | $374.0M | $256.7M | $1.3B |
| 48 | Dean & Barbara White Family Foundation INC Merrillville | T | $357.6M | $0 | $766.3M |
| 49 | Trine University INC Angola | B | $357.4M | $232.8M | $440.5M |
| 50 | Indiana Laborers Welfare Fund Terre Haute | Z | $343.9M | $143.0M | $405.6M |