| 1 | Deaconess Hospital INC | Health Care | $2.3B | $2.9B |
| 2 | Deaconess Health System INC | Health Care | $398.1M | $691.4M |
| 3 | Deaconess Clinic INC | Health Care | $170.9M | $95.6M |
| 4 | University of Evansville | Education | $141.3M | $380.2M |
| 5 | Deaconess Regional Healthcare Services Illinois INC | Health Care | $133.3M | $251.4M |
| 6 | University of Southern Indiana Foundation INC | Education | $52.1M | $205.0M |
| 7 | Community Foundation Alliance INC | Philanthropy, Voluntarism & Grantmaking | $42.5M | $149.0M |
| 8 | Tri State Food Bank INC | Unclassified | $32.3M | $10.7M |
| 9 | Southwestern Behavioral Healthcare INC | Mental Health & Crisis Intervention | $28.0M | $16.6M |
| 10 | William Lant Ridgway Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $25.2M | $33.4M |
| 11 | Aline and Edgar Igleheart Foundation INC | Environment | $24.7M | $88.0M |
| 12 | Advantix Development Corporation | Community Improvement & Capacity Building | $22.6M | $23.5M |
| 13 | Deaconess Specialty Physicians INC | Health Care | $21.1M | $18.8M |
| 14 | Evansville Goodwill Industries INC | Employment | $20.7M | $52.4M |
| 15 | Easter Seals Rehabilitation Center INC | Health Care | $20.7M | $16.7M |
| 16 | Community Action Program of Evansville and Vanderburgh County | Human Services | $17.0M | $13.5M |
| 17 | Young Mens Christian Association of Southwestern Indiana INC | Human Services | $16.8M | $59.5M |
| 18 | Holiday Management Foundation INC | Unclassified | $15.1M | $15.9M |
| 19 | Echo Community Health Care INC | Unclassified | $14.9M | $9.8M |
| 20 | Crescent Cresline Wabash Plastics Foundation INC | Unclassified | $13.7M | $19.2M |
| 21 | Welborn Baptist Foundation INC | Philanthropy, Voluntarism & Grantmaking | $13.6M | $96.4M |
| 22 | Koch Foundation INC | Unclassified | $13.5M | $42.4M |
| 23 | Lewis Brothers Bakeries INC Employee Benefit Trust | Unclassified | $12.0M | $610K |
| 24 | Sol and Arlene Bronstein Foundation II | Unclassified | $11.2M | $14.8M |
| 25 | Evansville Rescue Mission INC | Unclassified | $10.7M | $19.8M |
| 26 | Evansville Protestant Home INC | Human Services | $10.6M | $8.7M |
| 27 | Youth First INC | Mental Health & Crisis Intervention | $10.5M | $8.9M |
| 28 | Habitat for Humanity International INC | Housing & Shelter | $10.2M | $16.8M |
| 29 | Deaconess Health Kentucky INC | Health Care | $10.1M | $42.6M |
| 30 | William E Schmidt Foundation INC | Education | $10.0M | $34.4M |
| 31 | Southwestern Indiana Regional Council on Aging INC | Human Services | $9.6M | $7.8M |
| 32 | Patricia H Snyder Family Foundation | Philanthropy, Voluntarism & Grantmaking | $9.1M | $5.3M |
| 33 | Evansville Country Club INC | Unclassified | $9.0M | $15.0M |
| 34 | Alan W Sharon a Braun Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $7.8M | $12.2M |
| 35 | Junior Achievement of Southwestern Indiana INC | International, Foreign Affairs & National Security | $7.8M | $8.2M |
| 36 | Community Coordinated Child Care of S Indiana | Human Services | $7.8M | $5.0M |
| 37 | Southwestern Healthcare INC | Unclassified | $7.5M | $15.3M |
| 38 | Deaconess Illinois Clinic INC | Health Care | $7.2M | $10.0M |
| 39 | John & Wilma Boldden Tr | Philanthropy, Voluntarism & Grantmaking | $7.0M | $8.7M |
| 40 | Evansville Day School INC | Education | $6.8M | $4.3M |
| 41 | Scott Township Volunteer Fire Dept | Unclassified | $6.3M | $1.9M |
| 42 | Evansville Arc INC | Human Services | $6.1M | $5.6M |
| 43 | International Union of Painters and Allied Trades | Unclassified | $5.9M | $9.2M |
| 44 | Hillcrest Washington Youth Home INC | Mental Health & Crisis Intervention | $5.3M | $6.6M |
| 45 | Grow Southwest Indiana Workforceboard INC | Community Improvement & Capacity Building | $5.3M | $1.7M |
| 46 | Voluntary Employees Benefit Association for Employees and | Unclassified | $5.2M | $21.2M |
| 47 | Deaconess Vna Plus LLC | Health Care | $5.2M | $12.0M |
| 48 | Easter Seals Southwestern Indiana Incorporated | Human Services | $5.0M | $31.0M |
| 49 | First Midwest Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $4.9M | $10.7M |
| 50 | Evansville Vanderburgh County Convention & Visitors Bureau INC | Community Improvement & Capacity Building | $4.9M | $4.6M |
| 51 | United Association of Journeymen & Apprentices of the Plumbing & Pipe | Unclassified | $4.7M | $5.5M |
| 52 | Foundation for Youth INC | Youth Development | $4.7M | $21.8M |
| 53 | Boys and Girls Club of Evansville INC | Unclassified | $4.6M | $27.5M |
| 54 | Signature School INC | Education | $4.5M | $1.5M |
| 55 | Old National Bank Foundation INC | Philanthropy, Voluntarism & Grantmaking | $4.5M | $12.2M |
| 56 | Evsc Foundation INC | Philanthropy, Voluntarism & Grantmaking | $4.4M | $7.5M |
| 57 | United Way of Southwestern Indiana INC | Philanthropy, Voluntarism & Grantmaking | $4.4M | $9.7M |
| 58 | Southern Indiana Graduate Medical Education Consortium INC | Education | $4.3M | $642K |
| 59 | Echo Housing Corporation | Housing & Shelter | $4.1M | $10.4M |
| 60 | Downtown Evansville - Community Development Corporation | Community Improvement & Capacity Building | $4.1M | $2.9M |
| 61 | International Brotherhood of Electrical Workers | Unclassified | $4.0M | $4.2M |
| 62 | Aurora INC | Human Services | $3.8M | $2.5M |
| 63 | Memorial Community Development Corporation | Human Services | $3.6M | $6.0M |
| 64 | Joshuas City School Incorporated | Education | $3.6M | $3.1M |
| 65 | Wnin Tri-state Public Media INC | Unclassified | $3.4M | $5.2M |
| 66 | St. Vincent Early Learning Center INC | Unclassified | $3.4M | $3.3M |
| 67 | Evansville Museum of Arts and Science | Arts, Culture & Humanities | $3.3M | $22.4M |
| 68 | Vanderburgh County Humane Society INC | Animal-Related | $3.2M | $3.3M |
| 69 | Enterprise Zone Education and Training Center Corporation | Human Services | $3.2M | $3.8M |
| 70 | Laborers International Union of North America | Unclassified | $3.2M | $5.0M |
| 71 | United Methodist Youth Home INC | Human Services | $3.1M | $9.0M |
| 72 | Hadi Shriners | Unclassified | $3.1M | $3.1M |
| 73 | Hope of Evansville INC | Housing & Shelter | $2.9M | $3.8M |
| 74 | Pro Bono Indiana INC | Mental Health & Crisis Intervention | $2.8M | $1.4M |
| 75 | Evansville Plumbers Apprentice Training Trust Fund | Education | $2.8M | $3.1M |
| 76 | West Side Nut Club INC | Community Improvement & Capacity Building | $2.8M | $2.4M |
| 77 | John B Goodrich Charitable Trust Nect | Unclassified | $2.8M | $10.2M |
| 78 | Evansville Philharmonic Orchestra | Arts, Culture & Humanities | $2.8M | $5.4M |
| 79 | Dream Center Evansville | Religion-Related | $2.5M | $2.9M |
| 80 | Louis J Koch Family Childrens Museum of Evansville INC | Arts, Culture & Humanities | $2.5M | $4.1M |
| 81 | Wesselman Park Nature Society INC | Environment | $2.4M | $1.3M |
| 82 | Carver Community Organization INC | Human Services | $2.4M | $3.0M |
| 83 | Neca-ibew Electrical Jatc | Employment | $2.3M | $4.3M |
| 84 | Girl Scouts of Southwest Indiana INC | Youth Development | $2.3M | $4.2M |
| 85 | Ronald McDonald House Charities of the Ohio Valley INC | Health Care | $2.3M | $9.3M |
| 86 | German Twp Water District INC | Unclassified | $2.3M | $12.7M |
| 87 | Golf Gives Back | Recreation & Sports | $2.2M | $295K |
| 88 | YWCA of Evansville Indiana INC | Human Services | $2.2M | $7.2M |
| 89 | District of Evansville of the Society of St. Vincent de Paul INC | Human Services | $2.2M | $4.1M |
| 90 | Willard Library of Evansville | Education | $2.2M | $2.9M |
| 91 | Professional Child Care Association of Southwestern Indiana | Unclassified | $2.2M | $193K |
| 92 | International Brotherhood of Teamsters | Unclassified | $2.1M | $1.9M |
| 93 | Counseling for Change INC | Human Services | $2.1M | $902K |
| 94 | VFW Post 114 | Unclassified | $2.1M | $752K |
| 95 | Willard Library Foundation INC | Recreation & Sports | $1.8M | $4.8M |
| 96 | Nancy Huntington Irrv Tr | Human Services | $1.8M | $1.8M |
| 97 | Boy Scouts of America | Unclassified | $1.8M | $5.5M |
| 98 | International Association of Heat & Frost Insulators & Allied Workers | Unclassified | $1.8M | $3.5M |
| 99 | Goodwill Educates INC | Education | $1.7M | $501K |
| 100 | George a Ball Special Tr | Unclassified | $1.7M | $6.0M |