| 1 | Blessing Hospital | Health Care | $858.3M | $806.6M |
| 2 | Quincy University Corporation | Education | $71.4M | $49.3M |
| 3 | Western Catholic Union | Unclassified | $68.5M | $178.1M |
| 4 | Cfm Foundation | Philanthropy, Voluntarism & Grantmaking | $63.7M | $110.9M |
| 5 | Chaddock Attachment and Trauma Services | Unclassified | $28.4M | $20.5M |
| 6 | Blessing Corporate Services INC | Health Care | $23.3M | $26.5M |
| 7 | Community Foundation of the Quincy Area | Philanthropy, Voluntarism & Grantmaking | $22.2M | $65.0M |
| 8 | Good Samaritan Home of Quincy | Human Services | $21.4M | $30.5M |
| 9 | Chaddock | Human Services | $21.4M | $968K |
| 10 | Transitions of Western Illinois INC | Mental Health & Crisis Intervention | $18.1M | $13.1M |
| 11 | The Blessing Foundation INC | Health Care | $16.7M | $88.8M |
| 12 | Sunset Home | Health Care | $12.7M | $17.2M |
| 13 | Gene Grawe Fund INC | Philanthropy, Voluntarism & Grantmaking | $10.8M | $879K |
| 14 | Chaddock Childrens Foundation | Human Services | $8.8M | $10.9M |
| 15 | Members First Community Credit Union | Public & Societal Benefit | $7.9M | $95.5M |
| 16 | United Community Credit Union | Unclassified | $7.3M | $122.7M |
| 17 | Adams County Mental Health and Retardation Association INC | Human Services | $7.2M | $24.1M |
| 18 | Quincy Country Club | Unclassified | $6.5M | $8.3M |
| 19 | Quincy Notre Dame Foundation | Education | $6.3M | $28.2M |
| 20 | Keller Gorman Family Foundation | Philanthropy, Voluntarism & Grantmaking | $5.9M | $3.2M |
| 21 | J W Gardner II Camp Trust | Philanthropy, Voluntarism & Grantmaking | $5.9M | $17.4M |
| 22 | Transitions Foundation | Philanthropy, Voluntarism & Grantmaking | $4.2M | $9.2M |
| 23 | Young Mens Christian Association of West Central Illinois | Human Services | $3.4M | $3.2M |
| 24 | Quincy Area Network Against Domestic Abuse | Human Services | $3.2M | $1.8M |
| 25 | West Central Illinois Area Agency on Aging | Unclassified | $3.0M | $1.0M |
| 26 | Bella Ease | Public & Societal Benefit | $2.6M | $1.2M |
| 27 | Spring Lake Assn. | Unclassified | $2.6M | $2.0M |
| 28 | West Central Illinois Nutrition Project INC | Food, Agriculture & Nutrition | $2.3M | $141K |
| 29 | Horizons Social Services of Adams County INC | Food, Agriculture & Nutrition | $2.1M | $2.4M |
| 30 | Cheerful Home Association | Human Services | $2.1M | $2.5M |
| 31 | Good Samaritan Home Foundation | Human Services | $1.9M | $12.5M |
| 32 | J W Gardner II Foundation | Philanthropy, Voluntarism & Grantmaking | $1.7M | $4.1M |
| 33 | YWCA of Quincy Ill | Unclassified | $1.7M | $1.7M |
| 34 | United Way of Adams County INC | Philanthropy, Voluntarism & Grantmaking | $1.7M | $2.0M |
| 35 | West Central Illinois Aging and Disability Resource Center | Human Services | $1.6M | $415K |
| 36 | Boy Scouts of America | Youth Development | $1.5M | $5.6M |
| 37 | Court Appointed Special Advocates of Adams County | Civil Rights, Social Action & Advocacy | $1.5M | $467K |
| 38 | Historical Society of Quincy & Adams County Illinois | Arts, Culture & Humanities | $1.4M | $3.5M |
| 39 | Cornerstone Foundations for Families | Human Services | $1.3M | $917K |
| 40 | West Central Child Care Connection INC | Human Services | $1.3M | $388K |
| 41 | John Wood Community College Foundation | Education | $1.3M | $4.6M |
| 42 | Quincy Public Schools Foundation | Unclassified | $1.1M | $4.0M |
| 43 | Blessing Volunteers in Partnership | Health Care | $1.1M | $559K |
| 44 | Western Illinois School Employees Credit Union | Unclassified | $1.0M | $22.4M |
| 45 | Quincy Community Theatre | Arts, Culture & Humanities | $988K | $1.9M |
| 46 | Greenmount Cemetery Association | Mutual & Membership Benefit | $985K | $5.1M |
| 47 | Quincy Humane Society | Animal-Related | $968K | $4.5M |
| 48 | West Central Illinois Case Coordination Unit | Unclassified | $795K | $782K |
| 49 | Quincy Art Center | Arts, Culture & Humanities | $745K | $2.6M |
| 50 | Quincy Childrens Museum | Arts, Culture & Humanities | $701K | $2.5M |
| 51 | Great Commission Broadcasting Corporation | Arts, Culture & Humanities | $636K | $911K |
| 52 | West Central Illinois Center for Independent Living | Civil Rights, Social Action & Advocacy | $599K | $478K |
| 53 | Sheridan Swim Club | Recreation & Sports | $594K | $501K |
| 54 | Knowledge Center at Chaddock | Human Services | $579K | $2.3M |
| 55 | Quincy Cedar Crest Country Club | Unclassified | $548K | $1.2M |
| 56 | Backlund Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $548K | $2.6M |
| 57 | Connect Child and Family Solutions | Human Services | $539K | $385K |
| 58 | Columbus Home Association of Quincy INC | Mutual & Membership Benefit | $530K | $482K |
| 59 | J L Wade Foundation | Philanthropy, Voluntarism & Grantmaking | $529K | $331K |
| 60 | Quincy Society of Fine Arts | Arts, Culture & Humanities | $512K | $1.1M |
| 61 | Quincy Area Chamber of Commerce | Unclassified | $512K | $516K |
| 62 | Quincy Area Convention & Visitors Bureau | Unclassified | $511K | $164K |
| 63 | Great River Economic Development Foundation | Community Improvement & Capacity Building | $503K | $875K |
| 64 | Quincy Catholic Elementary Schools Foundation | Education | $501K | $1.6M |
| 65 | Quincy Medical Group Healthcare Foundation | Philanthropy, Voluntarism & Grantmaking | $495K | $861K |
| 66 | Chaddock Behavioral Health Services | Health Care | $485K | $180K |
| 67 | International Association of Fire Fighters | Unclassified | $467K | $231K |
| 68 | Sro Fund | Arts, Culture & Humanities | $454K | $1.3M |
| 69 | United in Christ | Education | $448K | $41K |
| 70 | Benevolent & Protective Order of Elks of the USA | Unclassified | $444K | $316K |
| 71 | Adams County Farm Bureau | Unclassified | $434K | $743K |
| 72 | Quincy Development Association | Housing & Shelter | $398K | $5.0M |
| 73 | Quincy Symphony Orchestra | Unclassified | $397K | $587K |
| 74 | J2 Family Foundation | Philanthropy, Voluntarism & Grantmaking | $387K | $3.9M |
| 75 | Mary Weems Barton Quincy Public Library Foundation | Education | $374K | $2.4M |
| 76 | Woodland Home for Orphans and Friendless | Unclassified | $363K | $2.3M |
| 77 | So That Project Nfp | Mental Health & Crisis Intervention | $347K | $166K |
| 78 | Harvest Hills INC | Unclassified | $345K | $1.6M |
| 79 | Historic Quincy Business District | Unclassified | $312K | $314K |
| 80 | Camp Callahan INC | Recreation & Sports | $303K | $610K |
| 81 | The Quincy Museum INC | Arts, Culture & Humanities | $287K | $545K |
| 82 | Two Rivers Council Foundation | Housing & Shelter | $286K | $671K |
| 83 | Nuessen Family Foundation | Philanthropy, Voluntarism & Grantmaking | $278K | $163K |
| 84 | Quincy Business & Technology Corporation | Community Improvement & Capacity Building | $271K | $1.0M |
| 85 | Quincy United Soccer Club INC | Youth Development | $262K | $127K |
| 86 | Hofmeister Foundation | Philanthropy, Voluntarism & Grantmaking | $262K | $1.2M |
| 87 | Quincy Montessori School | Education | $262K | $63K |
| 88 | Tony Kemp Ministries INC | Education | $259K | $402K |
| 89 | Housing 1989 | Housing & Shelter | $245K | $928K |
| 90 | International Association of Machinists & Aerospace Workers | Employment | $242K | $694K |
| 91 | Twin Oaks Club | Unclassified | $241K | $203K |
| 92 | Knights of Columbus | Unclassified | $235K | $508K |
| 93 | Quincy Athletic Development Association | Recreation & Sports | $229K | $201K |
| 94 | Well House INC Nfp | Crime & Legal-Related | $222K | $592K |
| 95 | Fishing for Freedom Quincy | Public & Societal Benefit | $217K | $213K |
| 96 | The Quincy Public Schools Friends of the Performing Arts | Education | $215K | $226K |
| 97 | Niemann Foods Foundation | Philanthropy, Voluntarism & Grantmaking | $213K | $1.5M |
| 98 | Gem City Scholarship Foundation | Unclassified | $209K | $1.6M |
| 99 | Quincy Area Project General Fund | Community Improvement & Capacity Building | $209K | $22K |
| 100 | Quincy Area Project Endowment Fund 31-06844 | Unclassified | $205K | $55K |