| 1 | Central States Southeast & Southwest Areas Health & Welfare F Chicago | Z | $56.5B | $5.5B | $16.6B |
| 2 | Advocate Health and Hospitals Corporation Downers Grove | E | $12.9B | $7.8B | $23.8B |
| 3 | University of Chicago Chicago | B | $10.5B | $4.9B | $15.0B |
| 4 | Northwestern Memorial Healthcare Chicago | E | $10.1B | $10.1B | $14.2B |
| 5 | Northwestern University Evanston | N | $6.5B | $4.2B | $19.2B |
| 6 | Ann & Robert H Lurie Childrens Hospital of Chicago Chicago | E | $6.1B | $1.5B | $3.6B |
| 7 | Feeding America Chicago | K | $5.2B | $5.0B | $573.7M |
| 8 | The Chicago Community Trust Chicago | T | $4.0B | $2.5B | $6.0B |
| 9 | John D & Catherine T Macarthur Foundation Chicago | T | $3.9B | $0 | $9.3B |
| 10 | Osf Healthcare System Peoria | E | $3.9B | $3.9B | $5.8B |
| 11 | Rush University Medical Center Chicago | E | $3.9B | $3.0B | $4.7B |
| 12 | Northshore University Healthsystem Arlington Hts | E | $3.8B | $2.3B | $6.8B |
| 13 | University of Chicago Medical Center Chicago | E | $3.8B | $3.2B | $4.8B |
| 14 | Alliant Credit Union Chicago | W | $3.0B | $1.3B | $19.5B |
| 15 | Builders Initiative Chicago | T | $2.3B | $0 | $1.7B |
| 16 | Northwestern Memorial Healthcare Chicago | E | $2.3B | $2.3B | $15.2B |
| 17 | Modern Woodmen of America Rock Island | Z | $1.9B | $1.9B | $18.2B |
| 18 | Midwestern University Downers Grove | B | $1.9B | $537.5M | $2.1B |
| 19 | Unite Here Health Oak Brook | Z | $1.9B | $1.5B | $1.4B |
| 20 | Memorial Health System Springfield | Z | $1.8B | $1.6B | $2.0B |
| 21 | University of Illinois Foundation Champaign | B | $1.8B | $671.3M | $3.6B |
| 22 | Loyola University of Chicago Chicago | B | $1.7B | $1.1B | $2.6B |
| 23 | American Medical Association Chicago | Z | $1.7B | $546.2M | $1.5B |
| 24 | Loyola University Medical Center Maywood | E | $1.7B | $1.7B | $4.2B |
| 25 | The Carle Foundation Hospital Urbana | E | $1.6B | $1.5B | $651.5M |
| 26 | Advocate North Side Health Network Downers Grove | E | $1.4B | $1.4B | $1.7B |
| 27 | Eder Financial INC Elgin | Z | $1.4B | $74.6M | $340.6M |
| 28 | Electrical Insurance Trustees Alsip | Z | $1.4B | $361.1M | $863.3M |
| 29 | Mercy Health Corporation Rockford | T | $1.3B | $148.2M | $1.3B |
| 30 | Line Construction Benefit Fund Lombard | Z | $1.2B | $1.2B | $1.9B |
| 31 | Depaul University Chicago | B | $1.1B | $918.1M | $1.9B |
| 32 | Delta Dental of Illinois Naperville | Z | $1.0B | $1.0B | $216.3M |
| 33 | Copley Memorial Hospital INC Aurora | E | $1.0B | $458.0M | $1.2B |
| 34 | Southern Illinois Hospital Services Carbondale | E | $1.0B | $765.6M | $1.5B |
| 35 | The Carle Foundation Urbana | E | $945.7M | $693.3M | $3.3B |
| 36 | Big Ten Conference INC Rosemont | Z | $934.1M | $928.1M | $292.3M |
| 37 | Edward Hospital Arlington Hts | E | $908.5M | $908.3M | $704.6M |
| 38 | Accenture United States Benefit Chicago | Y | $901.3M | $901.3M | $123.3M |
| 39 | Swedishamerican Hospital Rockford | E | $896.2M | $888.1M | $1.2B |
| 40 | Riverside Medical Center Kankakee | E | $877.9M | $528.8M | $833.5M |
| 41 | Howard G Buffett Foundation Decatur | T | $870.1M | $0 | $395.6M |
| 42 | Paul M Angell Family Foundation Chicago | T | $867.0M | $0 | $903.3M |
| 43 | Javon Bea Hospital Rockford | E | $863.6M | $465.1M | $774.0M |
| 44 | Chicago District Council of Carpenters Welfare Fund Chicago | Z | $860.5M | $432.8M | $1.4B |
| 45 | Blessing Hospital Quincy | E | $858.3M | $704.7M | $806.6M |
| 46 | National Association of Realtors Chicago | Z | $840.0M | $360.8M | $1.1B |
| 47 | Art Institute of Chicago Chicago | B | $828.0M | $493.8M | $2.1B |
| 48 | Midwest Operating Engineers Welfare Fund Countryside | Z | $822.4M | $801.8M | $2.3B |
| 49 | Misericordia Home Chicago | P | $821.3M | $130.9M | $979.4M |
| 50 | Sarah Bush Lincoln Health Center Mattoon | E | $747.5M | $626.2M | $1.2B |