| 1 | Washington University Physicians in Illinois INC | Health Care | $113.8M | $20.4M |
| 2 | Employers and Operating Engineers-520 Health and Welfare F | Unclassified | $37.6M | $64.1M |
| 3 | International Union of Bricklayers and Allied Craftworkers | Unclassified | $2.4M | $2.3M |
| 4 | Southern Illinois Construction Advancement Program | Unclassified | $1.7M | $5.3M |
| 5 | Southern Illinois Builders Association | Unclassified | $1.7M | $2.5M |
| 6 | Si Ice Hawks Hockey | Recreation & Sports | $923K | $440K |
| 7 | Discovery | Unclassified | $850K | $847K |
| 8 | Ofallon Panther Band Boosters INC | Education | $607K | $551K |
| 9 | Bricklayers Local 8 of Illinois Apprenticeship | Education | $579K | $2.1M |
| 10 | Karla Smith Foundation | Mental Health & Crisis Intervention | $545K | $450K |
| 11 | Ofallon-shiloh Chamber of Commerce Incorporated | Unclassified | $440K | $275K |
| 12 | Knights of Columbus Council Ofallon | Unclassified | $424K | $381K |
| 13 | Ofallon High School Endowment Fund Ltd | Philanthropy, Voluntarism & Grantmaking | $267K | $1.5M |
| 14 | Ofallon Fire Department of Ofallon Illinois | Unclassified | $243K | $869K |
| 15 | Society of St. Vincent de Paul | Human Services | $192K | $67K |
| 16 | Midwest Wing Fest INC | Public & Societal Benefit | $183K | $57K |
| 17 | Ofallon Little Panthers Football & Cheerleading Club | Recreation & Sports | $166K | $83K |
| 18 | Royal Order of Jesters | Unclassified | $155K | $143K |
| 19 | Fraternal Order of Police | Unclassified | $147K | $507K |
| 20 | O Fallon Community Food Pantry INC | Human Services | $144K | $309K |
| 21 | The Kreilick Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $116K | $1.3M |
| 22 | Mike Kelley Foundation | Recreation & Sports | $116K | $299K |
| 23 | Swing Fore Hope | Philanthropy, Voluntarism & Grantmaking | $115K | $36K |
| 24 | Central Youth Outreach Nfp | Religion-Related | $107K | $40K |
| 25 | Friends of the Ofallon Public Library | Education | $99K | $142K |
| 26 | Joshuas Great Things Foundation | Diseases, Disorders & Medical Disciplines | $75K | $47K |
| 27 | Rotary Intennational | Unclassified | $74K | $49K |
| 28 | PTO Il Ofallon Estelle Kampmeyer | Education | $73K | $21K |
| 29 | Metro East Landlords Association | Employment | $71K | $322K |
| 30 | Ofallon Sportsmans Club | Recreation & Sports | $71K | $335K |
| 31 | District 90 Ptd Presidents | Education | $71K | $42K |
| 32 | Living Lfs INC | Diseases, Disorders & Medical Disciplines | $60K | $42K |
| 33 | Ancient Free & Accepted Masons of Illinois | Unclassified | $59K | $433K |
| 34 | St. Louis Agri Business Club | Unclassified | $45K | $72K |
| 35 | American Legion 0137 Fischer- Sollis Post | Unclassified | $44K | $96K |
| 36 | Once Upon a Prayer | Animal-Related | $31K | $37K |
| 37 | Operating Engineers 520 Vacation Fund | Unclassified | $16K | $489K |
| 38 | Douthitt Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $6K | $722 |
| 39 | Charis Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1 | $30K |
| 40 | Roc N Robe Rtg | Recreation & Sports | $1 | $3K |
| 41 | Four Hearts Foundation INC | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 42 | Faith United Baptist Church | Religion-Related | $0 | $0 |
| 43 | O Fallon Veterans Monument Association INC | Arts, Culture & Humanities | $0 | $0 |
| 44 | Save Our Strays Nfp | Human Services | $0 | $0 |
| 45 | Peters Place Foundation Nfp | Human Services | $0 | $0 |
| 46 | Patriotic Sisters of the USA INC | Human Services | $0 | $0 |
| 47 | Partner in Missions INC | Religion-Related | $0 | $0 |
| 48 | Toastmasters International | Unclassified | $0 | $0 |
| 49 | Central Christian Church | Unclassified | $0 | $0 |
| 50 | Knights of Columbus | Unclassified | $0 | $0 |
| 51 | Assembly of God | Unclassified | $0 | $0 |
| 52 | Illinois State Grange | Unclassified | $0 | $0 |
| 53 | Ofallon Chapter 2281 Women of the Moose | Unclassified | $0 | $0 |
| 54 | Shoppes at Green Mount Association INC | Community Improvement & Capacity Building | $0 | $0 |
| 55 | Horizon Hope Counseling INC | Mental Health & Crisis Intervention | $0 | $0 |
| 56 | Early Childhood Development Foundation INC | Education | $0 | $0 |
| 57 | American Federation of Theachers | Education | $0 | $0 |
| 58 | Illinois Federation of Dog Clubs and Owners | Community Improvement & Capacity Building | $0 | $0 |
| 59 | John Wilt Foundation | Education | $0 | $0 |
| 60 | Belle Clair Rotary Foundation | Education | $0 | $0 |
| 61 | Renewed Life Ministries | Religion-Related | $0 | $0 |
| 62 | Family Motor Coach Association | Unclassified | $0 | $0 |
| 63 | Hudson-essex Terraplane Club INC | Unclassified | $0 | $0 |
| 64 | Mb Foundation | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 65 | Central 104 PTO | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 66 | Bombers Athletic Association | Recreation & Sports | $0 | $0 |
| 67 | Japanese Institute of St. Louis | Arts, Culture & Humanities | $0 | $0 |
| 68 | Without Limits - Team Galaxy | Recreation & Sports | $0 | $0 |
| 69 | Journey of Hope Home Corporation | Human Services | $0 | $0 |
| 70 | This Grow Round | Human Services | $0 | $0 |
| 71 | Todays Affirmations Charitable Foundation | Housing & Shelter | $0 | $0 |
| 72 | Gateway to Medicine | Education | $0 | $0 |
| 73 | Illinois State Grange | Unclassified | $0 | $0 |
| 74 | St. Clare Roman Catholic Church | Unclassified | $0 | $0 |
| 75 | First Baptist Church of Ofallon | Unclassified | $0 | $0 |
| 76 | Faith Lutheran Church | Unclassified | $0 | $0 |
| 77 | American Federation of Teachers | Unclassified | $0 | $0 |
| 78 | American Volkssport Association INC | Unclassified | $0 | $0 |
| 79 | American Federation of Teachers | Unclassified | $0 | $0 |
| 80 | American Federation of Teachers | Unclassified | $0 | $0 |
| 81 | Ofallon Historical Society INC | Unclassified | $0 | $0 |
| 82 | American Federation of Teachers | Unclassified | $0 | $0 |
| 83 | Southern Illinois Cardiovascular Facility INC | Unclassified | $0 | $441K |
| 84 | Blessed Savior Lutheran Church | Unclassified | $0 | $0 |
| 85 | American Federation of Teachers | Unclassified | $0 | $0 |
| 86 | O Fallon Womans Club INC | Unclassified | $0 | $0 |
| 87 | Ofallon Underwater Search and Recovery Team | Human Services | $0 | $0 |
| 88 | Jarrot Mansion Project INC | Arts, Culture & Humanities | $0 | $0 |
| 89 | Edward Fulton Junior High PTO | Unclassified | $0 | $0 |
| 90 | Sons of Union Veterans of the Civil War | Unclassified | $0 | $0 |
| 91 | Ofallon Apostolic Assembly | Unclassified | $0 | $0 |
| 92 | New Salem Baptist District Association | Religion-Related | $0 | $0 |
| 93 | Disciple Fellowship Christian Church INC | Religion-Related | $0 | $0 |
| 94 | American Federation of Teachers | Unclassified | $0 | $0 |
| 95 | St. Josephs Burial Association | Unclassified | $0 | $0 |
| 96 | Order of the Eastern Star of Illinois | Unclassified | $0 | $0 |
| 97 | National Society of the Daughters of the American Revolution | Unclassified | $0 | $0 |
| 98 | National Society of the Daughters of the American Revolution | Unclassified | $0 | $0 |
| 99 | Society of American Military Engineers | Unclassified | $0 | $0 |
| 100 | Kiwanis International INC | Unclassified | $0 | $0 |