| 1 | Mariners Hospital INC | Health Care | $120.2M | $62.1M |
| 2 | Florida Keys Electric Cooperative Assn INC | Mutual & Membership Benefit | $105.9M | $230.4M |
| 3 | Coral Restoration Foundation INC | Environment | $8.9M | $13.3M |
| 4 | Ocean Studies Charter School INC | Education | $5.2M | $7.0M |
| 5 | Florida Keys Childrens Shelter INC | Human Services | $2.9M | $2.7M |
| 6 | Good Health Clinic INC | Health Care | $2.7M | $1.3M |
| 7 | Benevolent & Protective Order of Elks of the USA | Unclassified | $887K | $821K |
| 8 | Ebert Charitable Foundation INC | Philanthropy, Voluntarism & Grantmaking | $872K | $4.4M |
| 9 | Florida Keys Wild Bird Rehabilitation Center INC | Animal-Related | $864K | $2.0M |
| 10 | Bailey Miller Foundation INC | Philanthropy, Voluntarism & Grantmaking | $591K | $481K |
| 11 | Upper Keys Rotary Foundation INC | Education | $482K | $316K |
| 12 | Charles G Wright Endowment for Humanity INC | Philanthropy, Voluntarism & Grantmaking | $313K | $3.9M |
| 13 | Casting for Cats INC | Animal-Related | $231K | $1.2M |
| 14 | Islamorada Community Entertainment INC | Arts, Culture & Humanities | $210K | $65K |
| 15 | Blue Water Surrender INC | Human Services | $169K | $376K |
| 16 | Fkec Members Charitable Trust INC | Philanthropy, Voluntarism & Grantmaking | $159K | $158K |
| 17 | Community Arts and Culture INC | Arts, Culture & Humanities | $148K | $4K |
| 18 | International Society for Reef Studies | Environment | $140K | $504K |
| 19 | Sereia Films INC | Arts, Culture & Humanities | $110K | $29K |
| 20 | Florida Keys United Soccer Club INC | Recreation & Sports | $94K | $31K |
| 21 | PTA Florida Congress | Unclassified | $88K | $69K |
| 22 | Rotary International | Unclassified | $65K | $28K |
| 23 | Key Players INC | Arts, Culture & Humanities | $47K | $86K |
| 24 | Four Corners Ministries INC | Religion-Related | $43K | $17K |
| 25 | Wilsie Lucille Foundation | Philanthropy, Voluntarism & Grantmaking | $28K | $145K |
| 26 | Crustacean Plantation INC | Animal-Related | $15K | $1K |
| 27 | Islamorada and Bay Institute Ofscience INC | Philanthropy, Voluntarism & Grantmaking | $8K | $15K |
| 28 | Near and Dear Foundation INC | Philanthropy, Voluntarism & Grantmaking | $4K | $4K |
| 29 | 1ST Marine Aircraft Wing Association-vietnam Service INC | Public & Societal Benefit | $0 | $0 |
| 30 | Lofty Ideas INC | Housing & Shelter | $0 | $0 |
| 31 | Tavernier Volunteer Fire Department and Ambulance Corp INC | Unclassified | $0 | $0 |
| 32 | We Fish for Kids INC | Recreation & Sports | $0 | $0 |
| 33 | Wildcats Girls Soccer Club INC | Recreation & Sports | $0 | $0 |
| 34 | Keys to Peace INC | Education | $0 | $0 |
| 35 | Keys to Valor | Public & Societal Benefit | $0 | $0 |
| 36 | Parent Booster USA INC | Education | $0 | $0 |
| 37 | Little Angels Global INC | Education | $0 | $0 |
| 38 | Avery J and Norma J Stilwell Founda Tion INC | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 39 | Friends of the Key Largo Cultural Center INC | Arts, Culture & Humanities | $0 | $0 |
| 40 | Key Largo Downtown Association INC | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 41 | Elite Dance of the Keys INC | Arts, Culture & Humanities | $0 | $0 |
| 42 | Garden Club of the Upper Keys INC | Environment | $0 | $0 |
| 43 | Shoun Howard Memorial Fund INC | Education | $0 | $0 |
| 44 | Its About Change INC | Human Services | $0 | $0 |
| 45 | Preservation & Conservation Society INC | Public & Societal Benefit | $0 | $0 |
| 46 | Association for Professionals in Infection Ctrl and Epidemiology in | Unclassified | $0 | $0 |
| 47 | Immanuel Evangelical Lutheran Church of the Upper Keys INC | Unclassified | $0 | $0 |
| 48 | Keys Jewish Community Center INC | Unclassified | $0 | $0 |
| 49 | Upper Keys Century Business & Professional Womens Club Florida | Unclassified | $0 | $0 |
| 50 | San Pedro Catholic Parish in Tavernier INC | Unclassified | $0 | $0 |
| 51 | Florida Keys Quilters INC | Arts, Culture & Humanities | $0 | $0 |
| 52 | Florida Keys Masonic Lodge 336 | Unclassified | $0 | $0 |
| 53 | Broken Vessel Ministries | Unclassified | $0 | $0 |
| 54 | Bay Harbor Association INC | Religion-Related | $0 | $0 |
| 55 | Coral Shores Athletic Booster Club INC | Education | $0 | $0 |
| 56 | Reach and Focus Forward INC | Public & Societal Benefit | $0 | $0 |
| 57 | Tabernero Bistro INC | Human Services | $0 | $0 |
| 58 | Saints in Practice Corp. | Arts, Culture & Humanities | $0 | $0 |
| 59 | Just Older Youth INC | Human Services | $0 | $0 |
| 60 | Islamorada Community Alliance | Community Improvement & Capacity Building | $0 | $0 |
| 61 | Turtle Team | Environment | $0 | $0 |
| 62 | Every Child is a Superhero INC | Youth Development | $0 | $0 |
| 63 | Upper Keys Baseball Development Foundation Corporation | Recreation & Sports | $0 | $0 |
| 64 | Upper Keys Youth Lacrosse League INC | Recreation & Sports | $0 | $0 |
| 65 | East Pacific Corridor Alliance INC | Education | $0 | $0 |
| 66 | Ocean Conservation Education INC | Environment | $0 | $0 |
| 67 | Remember It Church | Religion-Related | $0 | $0 |
| 68 | Skills for Christ INC | Education | $0 | $0 |
| 69 | Keys Accountability Project | Public & Societal Benefit | $0 | $0 |
| 70 | Conch Republic Area INC | Community Improvement & Capacity Building | $0 | $0 |