| 1 | Adventist Health System Sunbelt INC Altamonte Spg | E | $8.3B | $8.3B | $14.1B |
| 2 | University of Miami Coral Gables | B | $8.1B | $6.5B | $7.8B |
| 3 | Orlando Health INC Orlando | E | $5.3B | $4.8B | $9.5B |
| 4 | Florida Insurance Guaranty Association INC Tallahassee | Z | $5.2B | $825.6M | $827.3M |
| 5 | Florida Health Sciences Center INC Tampa | E | $5.0B | $3.2B | $5.5B |
| 6 | Baycare Health Systems INC Clearwater | E | $4.4B | $1.6B | $16.0B |
| 7 | Shriners Hospitals for Children Tampa | E | $3.6B | $1.8B | $11.9B |
| 8 | Adventist Health System Sunbelt Healthcare Corporation Altamonte Spg | E | $3.2B | $3.2B | $12.5B |
| 9 | Raymond James Charitable Endowment Fund St. Petersburg | T | $3.2B | $955.1M | $2.4B |
| 10 | Baptist Health of South Florida INC Coral Gables | E | $2.9B | $1.3B | $9.1B |
| 11 | Shands Teaching Hospital and Clinics INC Gainesville | E | $2.7B | $2.7B | $3.3B |
| 12 | Baptist Hospital of Miami INC Miami | E | $2.7B | $2.6B | $1.4B |
| 13 | Southern Baptist Hospital of Florida INC Jacksonville | E | $2.6B | $2.6B | $4.7B |
| 14 | The Nemours Foundation Jacksonville | E | $2.5B | $2.4B | $3.4B |
| 15 | H Lee Moffitt Cancer Center and Research Institute Hospital INC Tampa | E | $2.3B | $2.3B | $457.2M |
| 16 | St. Josephs Hospital INC Tampa | E | $2.0B | $2.0B | $3.4B |
| 17 | Alfred I Dupont Charitable Trust Jacksonville | E | $1.8B | $498.8M | $8.8B |
| 18 | Nova Southeastern University INC Ft Lauderdale | B | $1.7B | $1.0B | $2.1B |
| 19 | Pga Tour INC Ponte Vedra | Z | $1.6B | $760.6M | $3.9B |
| 20 | Capital Health Plan INC Tallahassee | Z | $1.5B | $1.2B | $756.9M |
| 21 | Mount Sinai Medical Center of Florida INC Miami Beach | E | $1.4B | $1.2B | $1.3B |
| 22 | University Community Hospital INC Tampa | E | $1.4B | $1.4B | $1.3B |
| 23 | Suncoast Credit Union Tampa | W | $1.4B | $1.1B | $17.8B |
| 24 | Lakeland Regional Medical Center INC Lakeland | E | $1.3B | $1.3B | $1.2B |
| 25 | Variety Childrens Hospital Miami | E | $1.3B | $1.0B | $1.8B |
| 26 | Embry-riddle Aeronautical Daytona Beach | B | $1.2B | $810.2M | $1.6B |
| 27 | Florida Clinical Practice Association INC Gainesville | Z | $1.2B | $1.2B | $382.3M |
| 28 | Shands Jacksonville Medical Center INC Jacksonville | E | $1.1B | $1.1B | $1.1B |
| 29 | Morton Plant Hospital Association INC Clearwater | E | $1.1B | $1.1B | $1.6B |
| 30 | Florida Hospital Medical Group INC Maitland | Z | $1.1B | $1.1B | $318.2M |
| 31 | Tallahassee Memorial Healthcare INC Tallahassee | E | $1.1B | $1.1B | $1.2B |
| 32 | Orlando Health Medical Group INC Orlando | E | $1.1B | $1.1B | $474.3M |
| 33 | Naples Community Hospital INC Naples | E | $988.4M | $880.7M | $1.2B |
| 34 | Holmes Regional Medical Center Rockledge | E | $948.8M | $948.7M | $1.0B |
| 35 | South Miami Hospital INC South Miami | E | $941.7M | $941.6M | $466.2M |
| 36 | Baptist Health Care INC Pensacola | E | $941.3M | $939.6M | $1.4B |
| 37 | Step Up for Students - Florida INC Jacksonville | B | $904.6M | $904.6M | $1.5B |
| 38 | State Chartered Credit Unions in Florida Jacksonville | Z | $901.6M | $886.1M | $14.0B |
| 39 | Boca Raton Regional Hospital INC Boca Raton | E | $837.3M | $837.2M | $1.4B |
| 40 | Memorial Health Systems INC Daytona Beach | E | $785.9M | $785.8M | $752.3M |
| 41 | Baptist Health Medical Group INC Coral Gables | E | $756.4M | $756.4M | $132.7M |
| 42 | Dechomai Asset Trust Jacksonville | T | $716.6M | $459.6M | $1.5B |
| 43 | Baycare Medical Group INC Tampa | E | $705.3M | $705.3M | $155.8M |
| 44 | West Kendall Baptist Hospital INC Miami | E | $686.3M | $683.7M | $351.5M |
| 45 | John S and James L Knight Foundation INC Miami | B | $675.1M | $0 | $2.5B |
| 46 | Holy Cross Hospital INC Ft Lauderdale | E | $663.8M | $663.7M | $499.4M |
| 47 | The Moorings Incorporated Naples | P | $643.1M | $162.2M | $1.2B |
| 48 | Trustees of Mease Hospital INC Dunedin | E | $638.1M | $637.4M | $1.2B |
| 49 | Lee County Electric Cooperative INC N Ft Myers | Z | $616.9M | $616.1M | $1.3B |
| 50 | Withlacoochee River Electric Cooperative INC Dade City | Z | $601.5M | $601.2M | $1.5B |