| 1 | Leesburg Regional Medical Center INC | Health Care | $293.6M | $160.4M |
| 2 | Lifestream Behavioral Center INC | Health Care | $62.5M | $75.3M |
| 3 | Beacon College INC | Unclassified | $42.4M | $38.8M |
| 4 | Caring Heart Rehabilitation and Nursing Center INC | Health Care | $30.1M | $42.9M |
| 5 | Lake Sumter State College Foundation INC | Education | $25.1M | $34.9M |
| 6 | Early Learning Coalition of Lake County | Education | $24.6M | $5.9M |
| 7 | Ncrnc INC | Health Care | $11.5M | $3.9M |
| 8 | Mattick Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $8.2M | $9.3M |
| 9 | Sunrisearc INC | Human Services | $5.4M | $3.1M |
| 10 | Wildlife Disease Association INC | Animal-Related | $3.5M | $7.5M |
| 11 | Educational Foundation of Lake County INC | Education | $2.7M | $5.8M |
| 12 | Mercy Flight Southeast INC | Health Care | $2.7M | $1.2M |
| 13 | Haven of Lake and Sumter Counties INC | Human Services | $2.6M | $1.7M |
| 14 | William W Weil Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.5M | $6.8M |
| 15 | Innovations Educational Services INC | Education | $2.5M | $2.9M |
| 16 | Lake Sumter Childrens Advocacy Center INC | Crime & Legal-Related | $2.4M | $6.5M |
| 17 | Forward Paths Foundation INC | Youth Development | $2.4M | $2.9M |
| 18 | Christian Care Center INC | Human Services | $2.3M | $2.3M |
| 19 | Amvets | Unclassified | $1.9M | $1.1M |
| 20 | Haines City Community Development INC | Unclassified | $1.5M | $3.4M |
| 21 | United Way of Lake and Sumter Counties INC | Philanthropy, Voluntarism & Grantmaking | $1.4M | $2.3M |
| 22 | Community Development Corproation of Leesburg and Vicinity INC | Community Improvement & Capacity Building | $1.3M | $3.7M |
| 23 | Marshall B Partin Foundation Tr | Philanthropy, Voluntarism & Grantmaking | $1.2M | $3.9M |
| 24 | International Linemans Museum INC | Arts, Culture & Humanities | $1.2M | $1.0M |
| 25 | World Ministries a New Jersey Non Profit Corporation | Religion-Related | $964K | $742K |
| 26 | American Federation of Teachers | Unclassified | $916K | $625K |
| 27 | Simple Truth Foundation INC | Food, Agriculture & Nutrition | $909K | $122K |
| 28 | Central Florida Health INC | Health Care | $888K | $223.9M |
| 29 | Care for Pastors INC | Religion-Related | $888K | $770K |
| 30 | Leesburg Regional Medical Center Foundation INC | Health Care | $803K | $10.3M |
| 31 | New Vision for Independence INC | Human Services | $785K | $606K |
| 32 | Leesburg Lodge No 1271 Loyal Order of Moose | Unclassified | $716K | $825K |
| 33 | Lake Economic Area Development Corporation | Community Improvement & Capacity Building | $715K | $450K |
| 34 | Seville Farm Family Housing Association INC | Housing & Shelter | $684K | $2.5M |
| 35 | West Leesburg Community Development Corporation | Community Improvement & Capacity Building | $631K | $0 |
| 36 | Public Housing Assistance INC | Housing & Shelter | $595K | $927K |
| 37 | Leesburg Cemeteries INC Fka Lone Oak Cemetery | Unclassified | $541K | $595K |
| 38 | Leesburg Humane Society INC | Animal-Related | $532K | $4.0M |
| 39 | Melon Patch Players INC | Unclassified | $485K | $246K |
| 40 | Community Medical Care Center INC | Health Care | $471K | $1.1M |
| 41 | Sebring Housing Research and Development INC | Housing & Shelter | $421K | $399K |
| 42 | Leesburg Area Chamber of Commerce INC | Unclassified | $406K | $103K |
| 43 | Amac Foundation INC | Human Services | $394K | $134K |
| 44 | Vietnamese - American Buddhist Association Niem Xu Thien Vien INC | Religion-Related | $389K | $6.9M |
| 45 | Club Hawthorne | Unclassified | $352K | $300K |
| 46 | International Association of Fire Fighters | Community Improvement & Capacity Building | $313K | $369K |
| 47 | Leesburg Food Bank INC | Unclassified | $232K | $1.2M |
| 48 | Glacc INC | Human Services | $219K | $332K |
| 49 | Buffalo Chase Foundation INC | Philanthropy, Voluntarism & Grantmaking | $201K | $191K |
| 50 | Gregg Strimenos Foundation INC | Philanthropy, Voluntarism & Grantmaking | $189K | $865K |
| 51 | Deaf Service Center of Lake County | Human Services | $188K | $79K |
| 52 | Lake Region Homes INC | Mental Health & Crisis Intervention | $164K | $232K |
| 53 | Milestones Community School of Lake County INC | Education | $160K | $36K |
| 54 | Florida State Florist Association | Unclassified | $149K | $30K |
| 55 | Restoration Ranch Therapeutic Riding INC | Human Services | $147K | $3K |
| 56 | Friends of the Leesburg Library Incorporated | Unclassified | $147K | $341K |
| 57 | Florida Presbyterian Disaster Assistance Network | Human Services | $127K | $157K |
| 58 | Larry L and Michele M Murphy Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $122K | $2.1M |
| 59 | Leesburg Yellow Jacket Booster Club | Education | $121K | $54K |
| 60 | Oldham Family Foundation | Philanthropy, Voluntarism & Grantmaking | $111K | $288K |
| 61 | Care Diversified of Lake County INC | Unclassified | $108K | $235K |
| 62 | 818 Missions International INC | Religion-Related | $104K | $219 |
| 63 | Serve International INC | Religion-Related | $103K | $109K |
| 64 | The Green Turtle Cay Foundation | International, Foreign Affairs & National Security | $103K | $727K |
| 65 | Leesburg Art Festival INC | Arts, Culture & Humanities | $84K | $36K |
| 66 | Lifestream Behavioral Center Foundation INC | Unclassified | $82K | $800K |
| 67 | Kristin Pooh Mason Foundation INC | Philanthropy, Voluntarism & Grantmaking | $81K | $359K |
| 68 | Lake-sumter Central Office INC | Mental Health & Crisis Intervention | $75K | $70K |
| 69 | Floridas Hometown USA Program INC | Education | $73K | $106K |
| 70 | Hodges Heroes | Recreation & Sports | $61K | $4K |
| 71 | Hope in Progress | Religion-Related | $55K | $70K |
| 72 | Cantaros de Bendicion INC | Religion-Related | $52K | $37K |
| 73 | Atlantic Coast Line & Seaboard Air Line Railroads Hist Society INC | Unclassified | $51K | $74K |
| 74 | Joy Foundation INC | Unclassified | $50K | $74K |
| 75 | Punishers Lemc Leesburg Chapter INC | Recreation & Sports | $44K | $1 |
| 76 | Albert Leroy Brown Foundation INC | Philanthropy, Voluntarism & Grantmaking | $36K | $455K |
| 77 | Hope 2 Restoration INC | Human Services | $34K | $831 |
| 78 | Quilting Sisters Guild | Education | $27K | $36K |
| 79 | Anjali Hindu Society of Central Florida INC | Religion-Related | $8K | $9K |
| 80 | H I S Royal Christian Academy INC | Unclassified | $2K | $24 |
| 81 | Wow Cares INC | Religion-Related | $2K | $241 |
| 82 | Artist with a Purpose | Unclassified | $1 | $1 |
| 83 | Hope Global Foundation INC | Human Services | $1 | $500 |
| 84 | Intl Assoc of Shrine Yacht Clubs | Unclassified | $0 | $0 |
| 85 | Eglise Baptiste des Rachetes | Unclassified | $0 | $0 |
| 86 | Gfwc Central Florida Womans Club | Community Improvement & Capacity Building | $0 | $0 |
| 87 | Because He Lives Outreach Ministry | Food, Agriculture & Nutrition | $0 | $0 |
| 88 | Prevent-educate INC | Arts, Culture & Humanities | $0 | $0 |
| 89 | Bullock Memorial Rodeo INC | Education | $0 | $0 |
| 90 | Anglican Catholic Church | Unclassified | $0 | $0 |
| 91 | Independent Associated Missions INC | Unclassified | $0 | $0 |
| 92 | Evangelistic Horizons Unlimited Incorporated | Religion-Related | $0 | $0 |
| 93 | Free & Accepted Masons of Florida | Unclassified | $0 | $0 |
| 94 | Gloria Dei Lutheran Church | Unclassified | $0 | $0 |
| 95 | Knights of Columbus | Unclassified | $0 | $0 |
| 96 | Order of the Eastern Star of Florida | Unclassified | $0 | $0 |
| 97 | African Women of Love Ministry | International, Foreign Affairs & National Security | $0 | $0 |
| 98 | Veterans Memorial at Fountain Park INC | International, Foreign Affairs & National Security | $0 | $0 |
| 99 | Animal Preservation Education Sanctuary INC | Animal-Related | $0 | $0 |
| 100 | Ember 911 | Education | $0 | $0 |