| 1 | Advanced Technology International Summerville, SC | $4.8B | $2.2B |
| 2 | Prisma Health - Upstate Greenville, SC | $3.2B | $1.3B |
| 3 | Prisma Health-midlands Greenville, SC | $1.8B | $909.4M |
| 4 | Lexington Health INC West Columbia, SC | $1.8B | $2.3B |
| 5 | Central Electric Power Cooperative INC Columbia, SC | $1.6B | $558.9M |
| 6 | McLeod Regional Medical Center of the Pee Dee INC Florence, SC | $1.3B | $2.7B |
| 7 | Prisma Health-university Medical Group Greenville, SC | $893.4M | $149.6M |
| 8 | Anmed Health Anderson, SC | $854.6M | $1.5B |
| 9 | St. Francis Hospital INC Greenville, SC | $850.9M | $586.8M |
| 10 | Bon Secours-st Francis Xavier Hospital INC Charleston, SC | $620.6M | $319.0M |
| 11 | The Blackbaud Giving Fund Daniel Island, SC | $561.4M | $52.7M |
| 12 | Roper Hospital INC Charleston, SC | $539.5M | $343.1M |
| 13 | Berkeley Electric Cooperative INC Moncks Corner, SC | $488.2M | $766.2M |
| 14 | Apella Health Management INC Spartanburg, SC | $473.8M | $78.4M |
| 15 | McLeod Loris Seacoast Hospital Loris, SC | $422.9M | $425.9M |
| 16 | Prisma Health Medical Group-midlands Greenville, SC | $386.1M | $112.3M |
| 17 | Conway Hospital INC Conway, SC | $358.2M | $798.3M |
| 18 | McLeod Health Florence, SC | $340.8M | $235.1M |
| 19 | Charter Institute at Erskine Columbia, SC | $299.9M | $17.4M |
| 20 | Furman University Greenville, SC | $288.9M | $1.4B |
| 21 | Georgetown Memorial Hospital Georgetown, SC | $267.1M | $65.8M |
| 22 | McLeod Physician Associates II Florence, SC | $258.0M | $73.9M |
| 23 | Medical Technology Enterprise Consortium Summerville, SC | $234.5M | $89.2M |
| 24 | Waccamaw Community Hospital Georgetown, SC | $225.6M | $273.9M |
| 25 | Horry Electric Cooperative INC Conway, SC | $215.7M | $479.1M |
| 26 | Prisma Health Tuomey Greenville, SC | $215.3M | $158.4M |
| 27 | Mpd Electric Cooperative INC Florence, SC | $214.9M | $401.9M |
| 28 | Roper Saint Francis Physicians Network Ladson, SC | $213.0M | $94.4M |
| 29 | Georgetown Hospital System Georgetown, SC | $209.5M | $614.4M |
| 30 | Blue Ridge Electric Cooperative Pickens, SC | $208.0M | $580.1M |
| 31 | Hopehealth INC Florence, SC | $200.5M | $141.3M |
| 32 | Greenville Health Corporation Greenville, SC | $196.3M | $59.2M |
| 33 | Palmetto Electric Cooperative INC Ridgeland, SC | $194.8M | $321.1M |
| 34 | Securing Assets for Education Moncks Corner, SC | $183.2M | $161.0M |
| 35 | Wofford College Spartanburg, SC | $171.4M | $761.0M |
| 36 | Laurens Electric Cooperative INC Laurens, SC | $163.1M | $335.7M |
| 37 | Mid-carolina Electric Cooperative INC Lexington, SC | $157.8M | $403.9M |
| 38 | Bon Secours Medical Group Greenville Specialty Care LLC Greenville, SC | $155.6M | $24.4M |
| 39 | Roper St. Francis Hospital-berkeley INC Summerville, SC | $152.1M | $281.9M |
| 40 | York Electric Cooperative INC York, SC | $151.2M | $282.1M |
| 41 | Anderson University Anderson, SC | $148.4M | $274.6M |
| 42 | Aiken Electric Cooperative INC Aiken, SC | $145.7M | $580.5M |
| 43 | The Blood Connection Incorporated Piedmont, SC | $144.4M | $101.9M |
| 44 | Roper St. Francis Mount Pleasant Hospital Mt Pleasant, SC | $139.7M | $86.6M |
| 45 | Prisma Health Greenville, SC | $136.6M | $3.8B |
| 46 | Santee Electric Cooperative INC Kingstree, SC | $135.9M | $282.8M |
| 47 | Mainsail Health Partners Charleston, SC | $125.7M | $345.8M |
| 48 | Sonoco Employees Benefit Trust Hartsville, SC | $121.2M | $304K |
| 49 | Charleston Southern University N Charleston, SC | $116.1M | $207.9M |
| 50 | Bju INC Greenville, SC | $114.9M | $106.3M |