| 1 | UPMC Pittsburgh, PA | $24.3B | $11.2B |
| 2 | National Philanthropic TR Jenkintown, PA | $15.9B | $42.2B |
| 3 | Trustees of the University of Pennsylvania Philadelphia, PA | $10.7B | $34.0B |
| 4 | Vanguard Charitable Endowment Program Malvern, PA | $6.4B | $22.2B |
| 5 | Highmark Health Pittsburgh, PA | $6.1B | $4.5B |
| 6 | The Childrens Hospital of Philadelphia Philadelphia, PA | $3.9B | $8.1B |
| 7 | University of Pittsburgh Pittsburgh, PA | $3.4B | $10.5B |
| 8 | Lehigh Valley Hospital Allentown, PA | $3.2B | $3.6B |
| 9 | Geisinger Health Plan Danville, PA | $3.2B | $1.1B |
| 10 | Miltons S Hershey Medical Center Hershey, PA | $2.9B | $3.8B |
| 11 | Thomas Jefferson University Hospital Philadelphia, PA | $2.6B | $2.5B |
| 12 | Health Partners Plans INC Philadelphia, PA | $2.6B | $724.5M |
| 13 | Opportunity Finance Network Philadelphia, PA | $2.3B | $2.6B |
| 14 | Temple University Hospital INC Philadelphia, PA | $2.3B | $1.6B |
| 15 | Geisinger Medical Center Danville, PA | $2.0B | $5.6B |
| 16 | Carnegie Mellon University Pittsburgh, PA | $2.0B | $7.2B |
| 17 | Geisinger Clinic Danville, PA | $1.9B | $5.4B |
| 18 | York Hospital York, PA | $1.7B | $2.6B |
| 19 | Main Line Hospitals INC Radnor, PA | $1.7B | $3.1B |
| 20 | Lancaster General Hospital Lancaster, PA | $1.6B | $1.2B |
| 21 | Thomas Jefferson University Philadelphia, PA | $1.6B | $5.1B |
| 22 | UPMC Pittsburgh, PA | $1.6B | $1.0B |
| 23 | Temple University-of the Commonwealth System of Higher Educ Philadelphia, PA | $1.6B | $4.1B |
| 24 | St. Lukes Hospital Bethlehem, PA | $1.6B | $3.6B |
| 25 | Reading Hospital West Reading, PA | $1.5B | $1.0B |
| 26 | Albert Einstein Healthcare Network Philadelphia, PA | $1.5B | $1.6B |
| 27 | Drexel University Philadelphia, PA | $1.4B | $2.9B |
| 28 | Pennsylvania Employees Benefit Harrisburg, PA | $1.3B | $1.2B |
| 29 | Presbyterian Medical Center of the University of Pennsylvania Health Philadelphia, PA | $1.3B | $968.4M |
| 30 | Community Behavorial Health Philadelphia, PA | $1.3B | $239.9M |
| 31 | National Elevator Industry Health Benefit Plan Newtown Sq, PA | $1.2B | $3.4B |
| 32 | Geisinger Wyoming Valley Medical Center Danville, PA | $1.0B | $868.5M |
| 33 | Wellspan Medical Group York, PA | $1.0B | $148.3M |
| 34 | Lehigh Valley Physician Group Allentown, PA | $1.0B | $423.3M |
| 35 | Gbu Financial Life Pittsburgh, PA | $1.0B | $4.7B |
| 36 | Steelworkers Health & Welfare Fund Pittsburgh, PA | $909.0M | $110.2M |
| 37 | Delta Dental of Pennsylvania Camp Hill, PA | $902.0M | $468.0M |
| 38 | Abington Memorial Hospital Abington, PA | $877.9M | $747.5M |
| 39 | Penn State Health Hershey, PA | $866.0M | $1.6B |
| 40 | St. Lukes Physician Group INC Bethlehem, PA | $865.6M | $120.0M |
| 41 | Pennsylvania Hospital of the Univ of Pennsylvania Health System Philadelphia, PA | $852.7M | $844.6M |
| 42 | Wellspan Health York, PA | $844.6M | $697.2M |
| 43 | Geisinger System Services Danville, PA | $836.9M | $2.7B |
| 44 | Kennedy University Hospital INC Philadelphia, PA | $817.0M | $1.3B |
| 45 | Milton Hershey School & School Trust Hershey, PA | $814.0M | $23.4B |
| 46 | UPMC Pittsburgh, PA | $772.2M | $10.0B |
| 47 | Lehigh University Bethlehem, PA | $748.5M | $3.3B |
| 48 | United Steelworkers Pittsburgh, PA | $694.0M | $2.1B |
| 49 | Jefferson Health-northeast Philadelphia, PA | $693.1M | $1.6B |
| 50 | Acts Retirement-life Communities INC Ft Washington, PA | $619.3M | $2.1B |