| 1 | Cleveland Clinic Foundation Independence, OH | $17.2B | $26.5B |
| 2 | Battelle Memorial Institute Columbus, OH | $13.3B | $1.8B |
| 3 | Bon Secours Mercy Health INC Blue Ash, OH | $11.5B | $14.4B |
| 4 | The Cleveland Clinic Foundation Cleveland, OH | $9.7B | $17.4B |
| 5 | Caresource Ohio INC Dayton, OH | $8.6B | $2.2B |
| 6 | University Hospitals Health System INC Shaker Hts, OH | $5.9B | $3.3B |
| 7 | Ohiohealth Corporation Grant Riverside Doctors Dublin Met Columbus, OH | $5.1B | $10.2B |
| 8 | Nationwide Childrens Hospital Columbus, OH | $4.3B | $9.0B |
| 9 | Childrens Hospital Medical Center Cincinnati, OH | $3.4B | $10.0B |
| 10 | Uc Healthcare System Cincinnati, OH | $2.6B | $1.8B |
| 11 | Ohiohealth Corporation Columbus, OH | $2.2B | $1.7B |
| 12 | Bon Secours Richmond Health System Cincinnati, OH | $2.0B | $0 |
| 13 | American Endowment Foundation Hudson, OH | $1.9B | $8.4B |
| 14 | Summa Health Group Return Akron, OH | $1.7B | $1.9B |
| 15 | Toledo Hospital Toledo, OH | $1.7B | $1.8B |
| 16 | Case Western Reserve University Cleveland, OH | $1.6B | $4.5B |
| 17 | Miami Valley Hospital Dayton, OH | $1.6B | $1.5B |
| 18 | Nationwide Childrens Hospital INC Columbus, OH | $1.6B | $428.7M |
| 19 | Childrens Hospital Medical Center of Akron Akron, OH | $1.5B | $2.5B |
| 20 | Caresource Dayton, OH | $1.5B | $2.8B |
| 21 | Caresource Georgia Co Dayton, OH | $1.5B | $657.1M |
| 22 | Mount Carmel Health System Columbus, OH | $1.4B | $3.2B |
| 23 | Christ Hospital Cincinnati, OH | $1.4B | $1.4B |
| 24 | Caresource Indiana INC Dayton, OH | $1.3B | $437.4M |
| 25 | Kettering College Miamisburg, OH | $1.2B | $1.5B |
| 26 | Kroger Co Health and Welfare Benefit TR for Collectively-bargai Cincinnati, OH | $1.2B | $0 |
| 27 | Ohio State University Physicians INC Columbus, OH | $1.1B | $528.4M |
| 28 | Aultman Health Foundation Group Return Canton, OH | $1.0B | $545.6M |
| 29 | The Good Samaritan Hospital of Cincinnati Ohio Dtd 01251995 Cincinnati, OH | $969.0M | $1.2B |
| 30 | University of Dayton Dayton, OH | $958.1M | $2.2B |
| 31 | University Hospitals Health System INC Shaker Hts, OH | $954.8M | $5.8B |
| 32 | Bethesda Hospital INC Cincinnati, OH | $917.3M | $1.3B |
| 33 | Buckeye Power INC Columbus, OH | $915.5M | $1.6B |
| 34 | Dayton Osteopathic Hospital Miamisburg, OH | $870.3M | $877.4M |
| 35 | Genesis Healthcare System Zanesville, OH | $759.9M | $728.1M |
| 36 | Christian Healthcare Ministries INC Barberton, OH | $754.7M | $292.8M |
| 37 | Dayton Childrens Hospital Dayton, OH | $741.3M | $1.8B |
| 38 | Jobsohio Beverage System Columbus, OH | $730.9M | $1.2B |
| 39 | Adena Health System Chillicothe, OH | $704.4M | $798.3M |
| 40 | 0005 Wright-patt Credit Union Beavercreek, OH | $600.7M | $9.1B |
| 41 | Mount Carmel Health Plan INC Columbus, OH | $598.5M | $501.8M |
| 42 | Southern Ohio Medical Center Portsmouth, OH | $586.4M | $624.7M |
| 43 | Southern Ohio Chamber Alliance Benefit Plan Cincinnati, OH | $556.4M | $61.4M |
| 44 | Genesis Healthcare System Zanesville, OH | $527.5M | $697.1M |
| 45 | Marietta Memorial Hospital Marietta, OH | $518.2M | $736.6M |
| 46 | Nationwide Insurance Companies & Affiliates Employee Health Care TR Columbus, OH | $516.7M | $102.9M |
| 47 | Oberlin College Oberlin, OH | $467.8M | $2.1B |
| 48 | Southwest General Health Center Cleveland, OH | $449.6M | $523.6M |
| 49 | Blanchard Valley Regional Health Center Findlay, OH | $413.7M | $677.3M |
| 50 | Columbus Foundation Columbus, OH | $411.6M | $2.8B |