| 1 | Vanderbilt University Medical Center Nashville | E | $8.0B | $7.7B | $6.6B |
| 2 | Vanderbilt University Nashville | B | $8.0B | $2.6B | $13.8B |
| 3 | American Lebanese Syrian Assoc Char INC Memphis | X | $6.4B | $2.9B | $10.0B |
| 4 | St. Jude Childrens Research Hospital INC Memphis | E | $2.0B | $2.0B | $11.7B |
| 5 | Methodist Healthcare-memphis Memphis | E | $2.0B | $2.0B | $1.2B |
| 6 | University Health System INC Knoxville | E | $1.6B | $1.6B | $1.3B |
| 7 | Erlanger Health Chattanooga | E | $1.3B | $1.3B | $997.0M |
| 8 | Mountain States Health Alliance Johnson City | E | $1.1B | $1.1B | $603.5M |
| 9 | Middle Tennessee Electric Membershi P Corporation Murfreesboro | Z | $991.4M | $991.2M | $1.2B |
| 10 | Baptist Memorial Hospital Memphis | E | $978.6M | $975.5M | $585.8M |
| 11 | Wellmont Health System Johnson City | E | $859.1M | $856.9M | $469.6M |
| 12 | Shelby County Health Care Corporation Memphis | E | $766.8M | $766.8M | $348.5M |
| 13 | Dialysis Clinic INC Nashville | E | $758.8M | $736.4M | $697.7M |
| 14 | Memorial Health Care System INC Chattanooga | Z | $715.0M | $715.0M | $494.3M |
| 15 | Chs Community Health Systems INC Veba Trust Franklin | Y | $680.1M | $680.1M | $7K |
| 16 | Southern District Ubc Health Trust Goodlettsvlle | J | $566.7M | $205.6M | $237.4M |
| 17 | Belmont University Nashville | B | $547.0M | $523.2M | $1.8B |
| 18 | Eastman Credit Union Kingsport | Z | $536.7M | $536.0M | $9.1B |
| 19 | The Community Fdn of Middle Tn INC Nashville | T | $524.7M | $239.9M | $832.0M |
| 20 | Youth Villages INC Bartlett | P | $483.5M | $483.5M | $354.3M |
| 21 | Parkwest Medical Center Knoxville | E | $473.3M | $469.8M | $289.9M |
| 22 | Ducks Unlimited INC Memphis | C | $459.8M | $443.6M | $459.6M |
| 23 | Methodist Lebonheur Healthcare Memphis | E | $439.8M | $439.8M | $2.4B |
| 24 | Fort Sanders Regional Medical Center Knoxville | E | $427.6M | $423.2M | $249.5M |
| 25 | Baptist Memorial Hospital Tipton Covington | E | $407.3M | $407.1M | $224.4M |
| 26 | Cumberland Electric Membership Corp. Clarksville | Z | $404.7M | $404.7M | $686.9M |
| 27 | Baptist Memorial Health Care Corporation Memphis | E | $398.1M | $351.2M | $1.7B |
| 28 | University of the South Sewanee | B | $373.2M | $192.8M | $851.0M |
| 29 | East Tennessee Childrens Hospital Association INC Knoxville | E | $366.4M | $365.4M | $665.5M |
| 30 | The Bill Gatton Foundation Bristol | Z | $328.6M | $0 | $930.7M |
| 31 | The University of Tennessee Foundat Ion INC Knoxville | B | $315.3M | $315.3M | $1.0B |
| 32 | Volunteer Energy Cooperative Decatur | Z | $314.8M | $314.8M | $394.5M |
| 33 | Knoxville Tva Employees Credit Unio Knoxville | Z | $296.9M | $296.9M | $4.6B |
| 34 | Lipscomb University Nashville | Z | $288.4M | $242.5M | $460.2M |
| 35 | Baptist Memorial Hospital - Jonesboro INC Memphis | E | $288.4M | $288.3M | $288.8M |
| 36 | Global Ministries Foundation Cordova | X | $278.0M | $1.1M | $5.2M |
| 37 | Kingsway Charities INC Bristol | Q | $266.5M | $266.3M | $131.3M |
| 38 | Duck River Electric Membership Corporation Shelbyville | Z | $264.0M | $263.6M | $352.5M |
| 39 | Lincoln Memorial University Harrogate | B | $259.1M | $258.9M | $472.8M |
| 40 | Nissan North America INC Voluntary Employees Beneficiary Association Franklin | Z | $250.8M | $250.8M | $21.0M |
| 41 | Baptist Memorial Medical Group INC Memphis | E | $241.0M | $241.0M | $517.4M |
| 42 | Covenant Health Knoxville | E | $240.3M | $235.7M | $2.0B |
| 43 | Meharry Medical College Nashville | B | $239.3M | $239.3M | $484.7M |
| 44 | Bill and Crissy Haslam Foundation Knoxville | T | $228.1M | $0 | $171.4M |
| 45 | Johnston Memorial Hospital INC Johnson City | E | $220.4M | $219.5M | $316.6M |
| 46 | Baptist Memorial Medical Ministries Employee Health & Welfare TR Memphis | Z | $217.7M | $217.7M | $10.9M |
| 47 | Rhodes College Memphis | B | $187.6M | $187.6M | $656.5M |
| 48 | Methodist Medical Center Knoxville | E | $187.1M | $184.4M | $93.7M |
| 49 | Dci Donor Services INC Nashville | E | $178.3M | $136.0M | $132.1M |
| 50 | Guardian Foundation INC Ooltewah | E | $173.5M | $173.5M | $129.9M |