| 1 | Advanced Technology International Summerville | U | $4.8B | $4.8B | $2.2B |
| 2 | Prisma Health - Upstate Greenville | E | $3.2B | $3.2B | $1.3B |
| 3 | Lexington Health INC West Columbia | E | $2.0B | $1.8B | $2.3B |
| 4 | Prisma Health-midlands Greenville | E | $1.8B | $1.8B | $909.4M |
| 5 | McLeod Regional Medical Center of the Pee Dee INC Florence | E | $1.7B | $1.3B | $2.7B |
| 6 | Central Electric Power Cooperative INC Columbia | Z | $1.6B | $1.6B | $558.9M |
| 7 | Prisma Health-university Medical Group Greenville | E | $893.6M | $893.4M | $149.6M |
| 8 | St. Francis Hospital INC Greenville | Z | $889.6M | $850.9M | $586.8M |
| 9 | Anmed Health Anderson | E | $860.0M | $854.6M | $1.5B |
| 10 | Bon Secours-st Francis Xavier Hospital INC Charleston | E | $621.0M | $620.6M | $319.0M |
| 11 | The Blackbaud Giving Fund Daniel Island | T | $561.4M | $561.4M | $52.7M |
| 12 | Furman University Greenville | B | $555.6M | $288.9M | $1.4B |
| 13 | Roper Hospital INC Charleston | E | $539.5M | $539.5M | $343.1M |
| 14 | Berkeley Electric Cooperative INC Moncks Corner | Z | $488.3M | $488.2M | $766.2M |
| 15 | Apella Health Management INC Spartanburg | T | $473.8M | $473.8M | $78.4M |
| 16 | The Medical University of South Carolina Foundation Charleston | H | $441.3M | $88.9M | $817.0M |
| 17 | McLeod Loris Seacoast Hospital Loris | E | $425.9M | $422.9M | $425.9M |
| 18 | Prisma Health Medical Group-midlands Greenville | B | $386.1M | $386.1M | $112.3M |
| 19 | Conway Hospital INC Conway | E | $358.5M | $358.2M | $798.3M |
| 20 | McLeod Health Florence | E | $340.8M | $340.8M | $235.1M |
| 21 | Wofford College Spartanburg | Z | $301.3M | $171.4M | $761.0M |
| 22 | Charter Institute at Erskine Columbia | B | $299.9M | $299.9M | $17.4M |
| 23 | Georgetown Memorial Hospital Georgetown | E | $267.2M | $267.1M | $65.8M |
| 24 | McLeod Physician Associates II Florence | E | $258.0M | $258.0M | $73.9M |
| 25 | Medical Technology Enterprise Consortium Summerville | U | $234.5M | $234.5M | $89.2M |
| 26 | Waccamaw Community Hospital Georgetown | E | $225.6M | $225.6M | $273.9M |
| 27 | Horry Electric Cooperative INC Conway | W | $215.7M | $215.7M | $479.1M |
| 28 | Prisma Health Tuomey Greenville | E | $215.3M | $215.3M | $158.4M |
| 29 | Mpd Electric Cooperative INC Florence | W | $214.9M | $214.9M | $401.9M |
| 30 | Roper Saint Francis Physicians Network Ladson | E | $213.1M | $213.0M | $94.4M |
| 31 | Georgetown Hospital System Georgetown | E | $209.6M | $209.5M | $614.4M |
| 32 | Blue Ridge Electric Cooperative Pickens | Z | $208.0M | $208.0M | $580.1M |
| 33 | Hopehealth INC Florence | E | $200.7M | $200.5M | $141.3M |
| 34 | Clemson University Foundation Clemson | B | $197.0M | $75.3M | $1.4B |
| 35 | Greenville Health Corporation Greenville | E | $196.3M | $196.3M | $59.2M |
| 36 | Palmetto Electric Cooperative INC Ridgeland | Z | $194.8M | $194.8M | $321.1M |
| 37 | Securing Assets for Education Moncks Corner | B | $183.2M | $183.2M | $161.0M |
| 38 | Joy Unspeakable Foundation Charleston | T | $176.3M | $0 | $463.9M |
| 39 | Laurens Electric Cooperative INC Laurens | W | $164.3M | $163.1M | $335.7M |
| 40 | Anderson University Anderson | B | $164.1M | $148.4M | $274.6M |
| 41 | Mid-carolina Electric Cooperative INC Lexington | Z | $157.8M | $157.8M | $403.9M |
| 42 | Bon Secours Medical Group Greenville Specialty Care LLC Greenville | E | $155.6M | $155.6M | $24.4M |
| 43 | Roper St. Francis Hospital-berkeley INC Summerville | E | $152.1M | $152.1M | $281.9M |
| 44 | York Electric Cooperative INC York | Z | $151.2M | $151.2M | $282.1M |
| 45 | University of South Carolina Educational Foundation Columbia | B | $147.9M | $84.7M | $731.7M |
| 46 | Agfirst-fcbt Employee Welfare Benefit TR Columbia | Y | $147.6M | $74.2M | $6.4M |
| 47 | The Blood Connection Incorporated Piedmont | E | $146.7M | $144.4M | $101.9M |
| 48 | Aiken Electric Cooperative INC Aiken | Z | $145.7M | $145.7M | $580.5M |
| 49 | Roper St. Francis Mount Pleasant Hospital Mt Pleasant | E | $139.7M | $139.7M | $86.6M |
| 50 | Prisma Health Greenville | E | $136.6M | $136.6M | $3.8B |