| 1 | UPMC Pittsburgh | Z | $25.7B | $24.3B | $11.2B |
| 2 | Trustees of the University of Pennsylvania Philadelphia | B | $20.4B | $10.7B | $34.0B |
| 3 | National Philanthropic TR Jenkintown | T | $15.9B | $15.9B | $42.2B |
| 4 | Vanguard Charitable Endowment Program Malvern | T | $12.4B | $6.4B | $22.2B |
| 5 | UPMC Pittsburgh | E | $8.3B | $772.2M | $10.0B |
| 6 | Highmark Health Pittsburgh | Z | $6.4B | $6.1B | $4.5B |
| 7 | Milton Hershey School & School Trust Hershey | B | $5.8B | $814.0M | $23.4B |
| 8 | University of Pittsburgh Pittsburgh | B | $5.3B | $3.4B | $10.5B |
| 9 | The Childrens Hospital of Philadelphia Philadelphia | E | $3.9B | $3.9B | $8.1B |
| 10 | Lehigh Valley Hospital Allentown | E | $3.8B | $3.2B | $3.6B |
| 11 | Geisinger Health Plan Danville | Z | $3.2B | $3.2B | $1.1B |
| 12 | Carnegie Mellon University Pittsburgh | Z | $3.1B | $2.0B | $7.2B |
| 13 | Miltons S Hershey Medical Center Hershey | E | $2.9B | $2.9B | $3.8B |
| 14 | John Templeton Foundation West Conshohocken | T | $2.7B | $0 | $3.6B |
| 15 | Thomas Jefferson University Hospital Philadelphia | E | $2.6B | $2.6B | $2.5B |
| 16 | Health Partners Plans INC Philadelphia | Z | $2.6B | $2.6B | $724.5M |
| 17 | American Electric Power System Employees Benefit TR Pittsburgh | Z | $2.4B | $336.6M | $14.0M |
| 18 | National Elevator Industry Health Benefit Plan Newtown Sq | Z | $2.4B | $1.2B | $3.4B |
| 19 | Temple University Hospital INC Philadelphia | E | $2.3B | $2.3B | $1.6B |
| 20 | Opportunity Finance Network Philadelphia | W | $2.3B | $2.3B | $2.6B |
| 21 | York Hospital York | E | $2.2B | $1.7B | $2.6B |
| 22 | Temple University-of the Commonwealth System of Higher Educ Philadelphia | B | $2.2B | $1.6B | $4.1B |
| 23 | Geisinger Medical Center Danville | E | $2.0B | $2.0B | $5.6B |
| 24 | UPMC Pittsburgh | E | $2.0B | $1.6B | $1.0B |
| 25 | Geisinger Clinic Danville | E | $1.9B | $1.9B | $5.4B |
| 26 | Main Line Hospitals INC Radnor | E | $1.7B | $1.7B | $3.1B |
| 27 | Thomas Jefferson University Philadelphia | B | $1.6B | $1.6B | $5.1B |
| 28 | Lancaster General Hospital Lancaster | E | $1.6B | $1.6B | $1.2B |
| 29 | Pennsylvania Employees Benefit Harrisburg | Z | $1.6B | $1.3B | $1.2B |
| 30 | United Steelworkers Pittsburgh | Z | $1.6B | $694.0M | $2.1B |
| 31 | St. Lukes Hospital Bethlehem | E | $1.6B | $1.6B | $3.6B |
| 32 | Reading Hospital West Reading | E | $1.5B | $1.5B | $1.0B |
| 33 | Albert Einstein Healthcare Network Philadelphia | Z | $1.5B | $1.5B | $1.6B |
| 34 | Drexel University Philadelphia | B | $1.5B | $1.4B | $2.9B |
| 35 | Gbu Financial Life Pittsburgh | Z | $1.4B | $1.0B | $4.7B |
| 36 | Presbyterian Medical Center of the University of Pennsylvania Health Philadelphia | E | $1.3B | $1.3B | $968.4M |
| 37 | The Deere & Company Welfare Benefit Veba for Salaried Employees Pittsburgh | Y | $1.3B | $35.8M | $2.2B |
| 38 | Community Behavorial Health Philadelphia | F | $1.3B | $1.3B | $239.9M |
| 39 | William Penn Foundation Philadelphia | Z | $1.2B | $0 | $3.4B |
| 40 | Swarthmore College Swarthmore | B | $1.2B | $361.6M | $3.6B |
| 41 | The Childrens Hospital of Philadelphia Foundation Philadelphia | E | $1.1B | $325.6M | $4.9B |
| 42 | Bucknell University Lewisburg | B | $1.1B | $423.6M | $1.7B |
| 43 | Glaxosmithkline Patient Access Programs Foundation Philadelphia | T | $1.1B | $0 | $85.3M |
| 44 | Geisinger Wyoming Valley Medical Center Danville | E | $1.0B | $1.0B | $868.5M |
| 45 | Lehigh Valley Physician Group Allentown | E | $1.0B | $1.0B | $423.3M |
| 46 | Wellspan Medical Group York | E | $1.0B | $1.0B | $148.3M |
| 47 | Lehigh University Bethlehem | B | $1.0B | $748.5M | $3.3B |
| 48 | Penn State Health Hershey | E | $979.4M | $866.0M | $1.6B |
| 49 | United States Steel Corporation Represented Retirees Benefit Trust Pittsburgh | Z | $955.7M | $45.5M | $1.6B |
| 50 | Steelworkers Health & Welfare Fund Pittsburgh | Z | $922.8M | $909.0M | $110.2M |