| 1 | Yale University New Haven | B | $14.9B | $6.8B | $55.2B |
| 2 | Yale New Haven Hospital New Haven | E | $5.0B | $4.6B | $5.4B |
| 3 | Peter and Carmen Lucia Buck Foundation INC Mystic | T | $3.4B | $0 | $2.8B |
| 4 | Common Fund for Non-profit Organizations Wilton | S | $3.0B | $173.6M | $3.6B |
| 5 | Hartford Hospital Hartford | E | $2.7B | $2.7B | $2.8B |
| 6 | Citibank NA Employees Association Stamford | Z | $2.4B | $3.1M | $54.0M |
| 7 | Americares Foundation INC Stamford | Q | $2.0B | $2.0B | $412.5M |
| 8 | Boehringer Ingelheim Cares Foundation INC Ridgefield | B | $1.7B | $0 | $251.9M |
| 9 | Dalio Family Fund INC Westport | P | $1.6B | $806.9M | $4.0B |
| 10 | Yale New Haven Health Services Corporation New Haven | E | $1.4B | $1.1B | $3.5B |
| 11 | Dalio Foundation INC Westport | T | $1.0B | $0 | $1.7B |
| 12 | Save the Children Federation INC Fairfield | Q | $948.4M | $920.5M | $548.8M |
| 13 | Wesleyan University Middletown | B | $937.5M | $449.0M | $2.4B |
| 14 | Quinnipiac University Hamden | B | $928.9M | $595.3M | $2.0B |
| 15 | Yale University Retiree Health Benefits Coverage TR New Haven | Y | $928.1M | $182.8M | $1.1B |
| 16 | Bridgeport Hospital Bridgeport | E | $920.3M | $910.0M | $691.4M |
| 17 | General Electric Company Insurance Plan Trust Co V a Diamante Norwalk | Z | $916.3M | $913.9M | $18.7M |
| 18 | Danbury Hospital Danbury | E | $904.9M | $903.8M | $905.8M |
| 19 | Saint Francis Hospital and Medical Center Hartford | E | $881.5M | $876.8M | $742.8M |
| 20 | Stamford Hospital Stamford | E | $867.1M | $852.4M | $1.3B |
| 21 | Hartford Foundation for Public Giving Hartford | T | $842.9M | $144.4M | $1.2B |
| 22 | Hospital of Central Connecticut at New Britain General and Bradley Me New Britain | E | $780.9M | $776.5M | $839.1M |
| 23 | Hartford Health Care Corporation Hartford | E | $748.1M | $707.6M | $3.4B |
| 24 | Trinity College Hartford | B | $696.8M | $272.9M | $1.2B |
| 25 | Hartford Healthcare Medical Group Specialists Pllc Wethersfield | F | $695.3M | $694.9M | $158.7M |
| 26 | Northeast Medical Group INC Stratford | Z | $647.1M | $647.0M | $117.8M |
| 27 | Svmc Holdings INC New Britain | E | $645.5M | $637.9M | $372.9M |
| 28 | Connecticut Childrens Medical Center Hartford | E | $637.6M | $637.6M | $1.0B |
| 29 | Middlesex Hospital Middletown | E | $626.2M | $539.7M | $614.1M |
| 30 | Fairfield University Fairfield | B | $616.6M | $489.3M | $1.2B |
| 31 | Greenwich Hospital Greenwich | E | $615.7M | $575.8M | $872.5M |
| 32 | William W Backus Hospital Norwich | E | $589.5M | $585.2M | $990.1M |
| 33 | Sacred Heart University Fairfield | B | $584.3M | $540.0M | $1.5B |
| 34 | Lawrence and Memorial Hospital INC New London | E | $507.4M | $501.4M | $427.0M |
| 35 | Zoom Foundation Greenwich | T | $477.6M | $0 | $1.3B |
| 36 | Midstate Medical Center Hartford | E | $445.0M | $443.4M | $517.2M |
| 37 | Norwalk Hospital Association Norwalk | E | $439.6M | $433.1M | $693.8M |
| 38 | Nuvance Health Medical Practice Ct INC Danbury | Z | $423.7M | $423.7M | $195.9M |
| 39 | University of New Haven West Haven | B | $415.9M | $379.7M | $455.1M |
| 40 | Saint Marys Hospital INC Hartford | E | $359.4M | $355.8M | $221.9M |
| 41 | The Mercy Hospital INC Hartford | E | $337.4M | $337.4M | $205.3M |
| 42 | University of Hartford West Hartford | B | $327.2M | $287.5M | $432.2M |
| 43 | Trinity Health of New England Provider Network Organization INC Hartford | Z | $290.2M | $290.1M | $34.7M |
| 44 | Community Foundation for Greater New Haven New Haven | T | $287.5M | $55.7M | $627.4M |
| 45 | Connecticut College New London | B | $278.4M | $191.8M | $755.0M |
| 46 | The Griffin Hospital Derby | E | $277.7M | $268.3M | $209.3M |
| 47 | Stamford Health Medical Group INC Stamford | E | $252.1M | $251.5M | $79.6M |
| 48 | Knobloch Family Foundation Fairfield | T | $224.3M | $0 | $163.2M |
| 49 | Hartford Healthcare Medical Group INC Wethersfield | E | $223.9M | $223.7M | $147.7M |
| 50 | Charlotte Hungerford Hospital Torrington | E | $218.7M | $217.0M | $207.2M |