| 251 | Saint Francis Hospital INC | Tulsa, Oklahoma | $4.1B | $1.8B | $2.0B |
| 252 | Long Island Jewish Medical Center | Westbury, New York | $4.1B | $4.6B | $5.7B |
| 253 | Temple University-of the Commonwealth System of Higher Educ | Philadelphia, Pennsylvania | $4.1B | $1.6B | $2.2B |
| 254 | New York-presbyterian Fund INC | New York, New York | $4.1B | $334.8M | $370.0M |
| 255 | Provident Resources Group INC | Baton Rouge, Louisiana | $4.1B | $356.1M | $356.1M |
| 256 | Rockefeller University | New York, New York | $4.0B | $501.0M | $795.4M |
| 257 | Kresge Foundation | Troy, Michigan | $4.0B | $0 | $9.6M |
| 258 | Presbyterian Healthcare Services | Albuquerque, New Mexico | $4.0B | $2.9B | $3.4B |
| 259 | Rady Childrens Hospital-san Diego | San Diego, California | $4.0B | $1.7B | $3.2B |
| 260 | Foundation for the Carolinas | Charlotte, North Carolina | $3.9B | $761.4M | $761.6M |
| 261 | Mother Cabrini Health Foundation | New York, New York | $3.9B | $0 | $1.6B |
| 262 | Pomona College | Claremont, California | $3.9B | $329.4M | $1.5B |
| 263 | Wellesley College | Wellesley, Massachusetts | $3.9B | $379.1M | $592.7M |
| 264 | Loma Linda University Medical Center INC | Loma Linda, California | $3.9B | $1.8B | $2.0B |
| 265 | North Shore University Hospital | Westbury, New York | $3.9B | $3.9B | $4.3B |
| 266 | Childrens Medical Center | Boston, Massachusetts | $3.9B | $338.4M | $868.9M |
| 267 | Prisma Health | Greenville, South Carolina | $3.8B | $136.6M | $136.6M |
| 268 | Harvard Private Capital Realty INC | Boston, Massachusetts | $3.8B | $120.5M | $644.8M |
| 269 | University of Richmond | Richmond, Virginia | $3.8B | $498.3M | $1.4B |
| 270 | Beth Israel Deaconess Medical Center INC | Boston, Massachusetts | $3.8B | $3.1B | $3.1B |
| 271 | Methodist Hospitals of Dallas | Dallas, Texas | $3.8B | $2.1B | $2.1B |
| 272 | Charles Stewart Mott Foundation | Flint, Michigan | $3.8B | $0 | $862.0M |
| 273 | Miltons S Hershey Medical Center | Hershey, Pennsylvania | $3.8B | $2.9B | $2.9B |
| 274 | Trustees of the Smith College | Northampton, Massachusetts | $3.7B | $390.1M | $914.7M |
| 275 | Swedish Health Services | Renton, Washington | $3.7B | $3.3B | $3.4B |
| 276 | University of California Berkeley Foundation | Berkeley, California | $3.7B | $509.3M | $739.8M |
| 277 | Lokahi Assurance Ltd | Oakland, California | $3.6B | $967.5M | $1.8B |
| 278 | John Muir Health | Walnut Creek, California | $3.6B | $2.0B | $2.3B |
| 279 | The Johns Hopkins Hospital | Baltimore, Maryland | $3.6B | $3.4B | $3.7B |
| 280 | St. Lukes Hospital | Bethlehem, Pennsylvania | $3.6B | $1.6B | $1.6B |
| 281 | John Templeton Foundation | West Conshohocken, Pennsylvania | $3.6B | $0 | $2.7B |
| 282 | Swarthmore College | Swarthmore, Pennsylvania | $3.6B | $361.6M | $1.2B |
| 283 | University of Illinois Foundation | Champaign, Illinois | $3.6B | $671.3M | $1.8B |
| 284 | University of Nebraska Foundation | Lincoln, Nebraska | $3.6B | $352.5M | $1.4B |
| 285 | Lehigh Valley Hospital | Allentown, Pennsylvania | $3.6B | $3.2B | $3.8B |
| 286 | Jack Joseph and Morton Mandel Foundation | Cleveland, Ohio | $3.6B | $0 | $401.8M |
| 287 | Duke Endowment | Charlotte, North Carolina | $3.6B | $0 | $1.7B |
| 288 | Common Fund for Non-profit Organizations | Wilton, Connecticut | $3.6B | $173.6M | $3.0B |
| 289 | Ascendium Education Group INC | Madison, Wisconsin | $3.6B | $94.9M | $173.4M |
| 290 | Ann & Robert H Lurie Childrens Hospital of Chicago | Chicago, Illinois | $3.6B | $1.5B | $6.1B |
| 291 | University of Colorado Foundation | Denver, Colorado | $3.5B | $456.1M | $456.1M |
| 292 | Texas Childrens Hospital Foundation | Bellaire, Texas | $3.5B | $25.7M | $1.6B |
| 293 | Moody Foundation | Galveston, Texas | $3.5B | $0 | $1.5B |
| 294 | Providence Health System-southern California | Seattle, Washington | $3.5B | $2.3B | $2.4B |
| 295 | The New York Community Trust | New York, New York | $3.5B | $322.6M | $1.1B |
| 296 | Yale New Haven Health Services Corporation | New Haven, Connecticut | $3.5B | $1.1B | $1.4B |
| 297 | Cedars-sinai Health System | Los Angeles, California | $3.5B | $41.3M | $41.3M |
| 298 | Christus Health | Irving, Texas | $3.5B | $1.2B | $3.6B |
| 299 | Fred Hutchinson Cancer Center | Seattle, Washington | $3.5B | $2.0B | $2.8B |
| 300 | Self Help Ventures Fund | Durham, North Carolina | $3.4B | $189.2M | $191.2M |