| 2201 | Riddle Memorial Hospital | Radnor, Pennsylvania | $462.2M | $286.9M | $287.5M |
| 2202 | Baylor Health Care System Foundation | Dallas, Texas | $462.2M | $74.6M | $505.5M |
| 2203 | Wyckoff Heights Medical Center | Brooklyn, New York | $462.0M | $406.3M | $406.3M |
| 2204 | Community Foundation of Elkhart County INC | Elkhart, Indiana | $461.3M | $58.8M | $144.1M |
| 2205 | Pennsylvania Cyber Charter School | Midland, Pennsylvania | $461.2M | $223.6M | $294.1M |
| 2206 | Gmto Corporation | Pasadena, California | $460.9M | $21.2M | $21.2M |
| 2207 | Crown Family Foundation | Chicago, Illinois | $460.5M | $63.4M | $102.5M |
| 2208 | Lipscomb University | Nashville, Tennessee | $460.2M | $242.5M | $288.4M |
| 2209 | Ducks Unlimited INC | Memphis, Tennessee | $459.6M | $443.6M | $459.8M |
| 2210 | Boca Raton Regional Hospital Foundation INC | Boca Raton, Florida | $459.6M | $42.2M | $152.5M |
| 2211 | Marvin M Schwan Charitable Foundation | Earth City, Missouri | $459.5M | $49.2M | $1.5B |
| 2212 | The Smith Center for the Performing Arts | Las Vegas, Nevada | $459.5M | $37.0M | $54.7M |
| 2213 | Metropolitan Hospital | Wyoming, Michigan | $459.3M | $602.7M | $602.7M |
| 2214 | Johns Hopkins Bayview Medical Center INC | Baltimore, Maryland | $459.3M | $805.6M | $807.9M |
| 2215 | University of la Verne | La Verne, California | $459.2M | $214.4M | $281.5M |
| 2216 | United States Soccer Federation INC | Fayetteville, Georgia | $458.8M | $268.1M | $288.2M |
| 2217 | Cal Farleys Boys Ranch Foundation | Amarillo, Texas | $458.7M | $27.0M | $79.7M |
| 2218 | University of South Alabama Foundation | Mobile, Alabama | $458.3M | $11.3M | $16.1M |
| 2219 | University of Maine Foundation | Orono, Maine | $458.3M | $60.4M | $112.3M |
| 2220 | Central New York Community Foundation INC | Syracuse, New York | $458.3M | $50.7M | $61.8M |
| 2221 | Rideout Memorial Hospital | Roseville, California | $457.9M | $495.9M | $495.9M |
| 2222 | James S McDonnell Foundation | Saint Louis, Missouri | $457.5M | $0 | $67.4M |
| 2223 | Ray and Kay Eckstein Charitable Trust | Paducah, Kentucky | $457.4M | $0 | $189.3M |
| 2224 | National Board of Medical Examiners | Philadelphia, Pennsylvania | $457.2M | $189.8M | $291.0M |
| 2225 | H Lee Moffitt Cancer Center and Research Institute Hospital INC | Tampa, Florida | $457.2M | $2.3B | $2.3B |
| 2226 | The Champlin Foundation | Wilmington, Delaware | $456.6M | $0 | $232.7M |
| 2227 | Wallis Annenberg Legacy Foundation | Playa Vista, California | $456.5M | $0 | $279.0M |
| 2228 | Cincinnati Center City Development Corporation | Cincinnati, Ohio | $456.4M | $65.5M | $65.7M |
| 2229 | Ainslie Foundation | Dallas, Texas | $456.1M | $0 | $1.2M |
| 2230 | May and Stanley Smith Charitable Trust | Larkspur, California | $456.1M | $0 | $109.4M |
| 2231 | St. Luke S Hospital- Grand View Campus | Sellersville, Pennsylvania | $455.4M | $283.0M | $283.0M |
| 2232 | Equal Justice Initiative | Montgomery, Alabama | $455.3M | $79.6M | $276.5M |
| 2233 | Ronald Reagan Presidential Foundation and Institute | Simi Valley, California | $455.2M | $46.0M | $48.8M |
| 2234 | University of New Haven | West Haven, Connecticut | $455.1M | $379.7M | $415.9M |
| 2235 | Peconic Land Trust Incorporated | Southampton, New York | $455.0M | $28.1M | $47.7M |
| 2236 | Legacy Emanuel Hospital & Health Center | Portland, Oregon | $454.9M | $1.2B | $1.2B |
| 2237 | Los Angeles County Museum of Natural History Foundation | Los Angeles, California | $454.9M | $75.1M | $251.9M |
| 2238 | W K Kellogg Foundation | Battle Creek, Michigan | $454.4M | $0 | $444.0M |
| 2239 | University Athletic Association INC | Gainesville, Florida | $454.2M | $191.9M | $246.4M |
| 2240 | Ssm Health Care of Oklahoma INC | Saint Louis, Missouri | $453.7M | $1.1B | $1.1B |
| 2241 | Clark Foundation | Cooperstown, New York | $453.7M | $0 | $74.1M |
| 2242 | Valley Baptist Legacy Foundation | Harlingen, Texas | $453.3M | $0 | $142.3M |
| 2243 | Taylor University | Upland, Indiana | $453.3M | $186.7M | $237.9M |
| 2244 | Montana State University Foundation | Bozeman, Montana | $453.2M | $101.1M | $176.3M |
| 2245 | Goodwin House Incorporated | Alexandria, Virginia | $453.2M | $114.7M | $114.7M |
| 2246 | Georgia Tech Athletic Association | Atlanta, Georgia | $452.4M | $155.2M | $155.2M |
| 2247 | Ralph M Parsons Foundation | Los Angeles, California | $452.4M | $0 | $80.7M |
| 2248 | Noblis INC | Reston, Virginia | $452.3M | $614.5M | $673.8M |
| 2249 | Alfred University | Alfred, New York | $451.9M | $136.3M | $155.8M |
| 2250 | The Powell Foundation | Houston, Texas | $451.5M | $0 | $77.8M |