| 1951 | Henry Ford Health St. John Hospital | Detroit, Michigan | $532.9M | $1.1B | $1.1B |
| 1952 | Baton Rouge General Medical Center | Baton Rouge, Louisiana | $532.8M | $688.7M | $711.6M |
| 1953 | Morehouse College | Atlanta, Georgia | $532.8M | $183.1M | $242.3M |
| 1954 | W W Caruth Jr Foundation | Dallas, Texas | $531.5M | $38.4M | $50.2M |
| 1955 | East Bay Community Foundation | Oakland, California | $531.1M | $41.2M | $41.2M |
| 1956 | University of Nevada-reno Foundation | Reno, Nevada | $530.8M | $52.5M | $107.2M |
| 1957 | Chester County Hospital | West Chester, Pennsylvania | $530.5M | $507.4M | $507.4M |
| 1958 | Banner University Family Care | Phoenix, Arizona | $530.4M | $2.0B | $2.0B |
| 1959 | Presence St. Marys Hospital Presence Central and Suburban Hospitals Net | Saint Louis, Missouri | $530.0M | $807.2M | $807.3M |
| 1960 | Delaware State University | Dover, Delaware | $529.9M | $266.3M | $270.5M |
| 1961 | Zoma Foundation | Denver, Colorado | $529.5M | $0 | $312.5M |
| 1962 | Oklahoma Medical Research Foundation | Oklahoma City, Oklahoma | $528.8M | $132.3M | $214.5M |
| 1963 | Ohio State University Physicians INC | Columbus, Ohio | $528.4M | $1.1B | $1.2B |
| 1964 | Corporation for Better Housing | Woodland Hls, California | $527.9M | $7.8M | $7.8M |
| 1965 | Firelands Regional Medical Center | Sandusky, Ohio | $527.5M | $313.6M | $355.7M |
| 1966 | Shed Nyc INC | New York, New York | $527.3M | $32.8M | $38.1M |
| 1967 | Success Academy Charter Schools INC | New York, New York | $527.3M | $211.0M | $236.9M |
| 1968 | National Trust for Historic Preservation in the United States | Washington, District of Columbia | $527.2M | $104.1M | $135.1M |
| 1969 | Colorado Gives Foundation | Arvada, Colorado | $527.1M | $115.2M | $246.4M |
| 1970 | Valhalla Foundation | Woodside, California | $527.1M | $0 | $343.3M |
| 1971 | Wounded Warrior Project INC | Jacksonville, Florida | $526.8M | $385.2M | $470.0M |
| 1972 | Sid W Richardson Foundation | Fort Worth, Texas | $526.8M | $0 | $90.4M |
| 1973 | Tom T East Sr & Alice K East & Alice H East & Robert C East Wildl | San Antonio, Texas | $526.3M | $14.9M | $17.0M |
| 1974 | Grameen America INC | New York, New York | $526.2M | $141.8M | $141.8M |
| 1975 | Greater Fairbanks Community Hospital Foundation INC | Fairbanks, Alaska | $525.8M | $51.5M | $152.1M |
| 1976 | Hampton Roads Community Foundation | Norfolk, Virginia | $524.1M | $20.0M | $27.1M |
| 1977 | Infirmary Health System INC | Mobile, Alabama | $523.9M | $92.8M | $107.1M |
| 1978 | Alzheimers Disease and Related Disorders Association INC | Chicago, Illinois | $523.7M | $457.2M | $612.6M |
| 1979 | Xavier University of Louisiana | New Orleans, Louisiana | $523.6M | $158.7M | $424.2M |
| 1980 | Southwest General Health Center | Cleveland, Ohio | $523.6M | $449.6M | $541.1M |
| 1981 | Young Mens Christian Association of Greater New York | New York, New York | $523.3M | $241.4M | $408.6M |
| 1982 | Providence Saint Johns Health Center | Seattle, Washington | $523.1M | $499.5M | $501.6M |
| 1983 | Hexagon Foundation | Colorado Spgs, Colorado | $522.9M | $506.0M | $506.0M |
| 1984 | Biola University INC | La Mirada, California | $522.4M | $250.2M | $333.0M |
| 1985 | Des Moines University Osteopathic Medical Center | Des Moines, Iowa | $522.1M | $108.2M | $151.0M |
| 1986 | Nsf International | Ann Arbor, Michigan | $521.9M | $203.1M | $215.8M |
| 1987 | Hillcrest Baptist Medical Center | Dallas, Texas | $521.8M | $522.0M | $745.2M |
| 1988 | Robert Rauschenberg Foundation | New York, New York | $521.7M | $0 | $169.4M |
| 1989 | Northwest Community Hospital | Arlington Hts, Illinois | $521.7M | $633.8M | $634.6M |
| 1990 | Wisconsin Housing Preservation Corp. | Madison, Wisconsin | $521.6M | $79.2M | $96.6M |
| 1991 | The American Electric Power System Retiree Medical Benefit Trust for | Pittsburgh, Pennsylvania | $521.0M | $41.1M | $57.1M |
| 1992 | University of New Mexico Foundation Incorporated | Albuquerque, New Mexico | $520.4M | $77.7M | $126.2M |
| 1993 | Elbridge Stuart Foundation | San Francisco, California | $520.3M | $0 | $100.0M |
| 1994 | Legacy Enhancement | Monaca, Pennsylvania | $519.2M | $0 | $6.4M |
| 1995 | Community Foundation of Sarasota County INC | Sarasota, Florida | $518.5M | $87.0M | $212.5M |
| 1996 | Greater Washington Community Foundation | Washington, District of Columbia | $518.3M | $123.2M | $392.1M |
| 1997 | Goldman Sachs Charitable Gift Fund | New York, New York | $518.0M | $206.6M | $815.8M |
| 1998 | Garnet Health Medical Center | Middletown, New York | $518.0M | $664.2M | $742.5M |
| 1999 | Norwich University | Northfield, Vermont | $517.6M | $198.9M | $215.7M |
| 2000 | Baptist Memorial Medical Group INC | Memphis, Tennessee | $517.4M | $241.0M | $241.0M |