| 1 | Community Foundation for the Fox Valley Region INC | Philanthropy, Voluntarism & Grantmaking | $298.8M | $536.6M |
| 2 | Thedacare Regional Medical Center- Appleton INC | Health Care | $237.8M | $897.8M |
| 3 | Lawrence University of Wisconsin | Education | $193.5M | $653.8M |
| 4 | Thedacare Regional Medical Center - Neenah INC | Health Care | $150.9M | $684.8M |
| 5 | Young Mens Christian Association of the Fox Cities INC | Human Services | $35.4M | $66.6M |
| 6 | Thedacare Medical Center-berlin INC | Health Care | $29.0M | $58.6M |
| 7 | Thedacare Medical Center-waupaca INC | Health Care | $28.4M | $156.0M |
| 8 | Boys & Girls Club Fox Valley INC | Human Services | $27.8M | $33.4M |
| 9 | Community Blood Center INC | Health Care | $25.8M | $29.3M |
| 10 | Valley Packaging Industries INC | Employment | $22.9M | $15.4M |
| 11 | Girl Scouts of the Northwestern Great Lakes INC | Youth Development | $19.3M | $15.5M |
| 12 | Thedacare Medical Center New London INC | Health Care | $18.8M | $146.6M |
| 13 | Fox Cities Performing Arts Center INC | Arts, Culture & Humanities | $16.9M | $88.0M |
| 14 | Boy Scouts of America | Youth Development | $16.6M | $28.6M |
| 15 | National Association of Tax Professionals INC | Unclassified | $16.4M | $14.9M |
| 16 | Mosaic Family Health INC | Health Care | $16.0M | $13.8M |
| 17 | Partnership Community Health Center INC | Health Care | $15.8M | $11.6M |
| 18 | Catalpa Health INC | Diseases, Disorders & Medical Disciplines | $13.8M | $9.9M |
| 19 | US Venture-schmidt Family Foundation INC | Unclassified | $11.1M | $5.4M |
| 20 | Agape of Appleton INC | Unclassified | $10.4M | $5.0M |
| 21 | Thomas a Plein Foundation Ltd | Unclassified | $9.7M | $8.7M |
| 22 | William J & Barbara a Schmidt Family Foundation INC | Employment | $9.1M | $7.0M |
| 23 | Pillars INC | Housing & Shelter | $8.6M | $11.1M |
| 24 | Fox Valley Technical College Foundation INC | Unclassified | $7.4M | $26.2M |
| 25 | Mooring Programs Incorporated | Unclassified | $7.1M | $2.3M |
| 26 | Thedacare Medical Center-wild Rose INC | Health Care | $6.7M | $5.4M |
| 27 | Allen Foundation | Unclassified | $6.6M | $16.0M |
| 28 | American Opinion Foundation INC | Arts, Culture & Humanities | $6.6M | $7.8M |
| 29 | Mielke Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $5.8M | $12.2M |
| 30 | International Conference on Learning Representations | Science & Technology | $5.1M | $3.6M |
| 31 | Butte des Morts Country Club INC | Unclassified | $4.8M | $5.6M |
| 32 | Trout Museum of Art INC | Arts, Culture & Humanities | $4.7M | $16.1M |
| 33 | Francie Luke Silverman Foundation Under the Francie Silverman | Philanthropy, Voluntarism & Grantmaking | $4.6M | $12.7M |
| 34 | Appleton Education Foundation INC | Crime & Legal-Related | $4.2M | $12.2M |
| 35 | Life Promotions INC | Youth Development | $4.0M | $2.1M |
| 36 | Plumbing and Pipefitting Educational Program | Education | $3.8M | $3.8M |
| 37 | Tri-county Community Dental Clinic INC | Health Care | $3.7M | $6.8M |
| 38 | Thompson Center on Lourdes INC | Human Services | $2.9M | $5.5M |
| 39 | The Building for Kids INC | Arts, Culture & Humanities | $2.8M | $4.4M |
| 40 | US 2 Behavioral Health Care INC | Mental Health & Crisis Intervention | $2.8M | $2.7M |
| 41 | Harbor House Domestic Abuse Programs INC | Employment | $2.7M | $9.1M |
| 42 | Fox Cities Sports Development INC | Recreation & Sports | $2.6M | $1.4M |
| 43 | Fox Cities Convention & Visitors Bureau INC | Unclassified | $2.6M | $7.4M |
| 44 | Fox Valley Lutheran High School Endowment Fund INC | Education | $2.6M | $3.5M |
| 45 | Villa Hope Incorporated | Unclassified | $2.6M | $1.3M |
| 46 | The Family Radio Network INC | Unclassified | $2.6M | $6.6M |
| 47 | Womens Fund for the Fox Valley Region INC | Unclassified | $2.5M | $3.8M |
| 48 | Fox Cities Chamber of Commerce & Industry INC | Unclassified | $2.3M | $1.7M |
| 49 | Realtors Associations of Northeast Wisconsin INC | Unclassified | $2.3M | $6.6M |
| 50 | Vida INC | Unclassified | $2.2M | $5.1M |
| 51 | Appleton Y M C a Endowment Trust | Human Services | $2.1M | $5.5M |
| 52 | Thedacare Family of Foundations INC | Philanthropy, Voluntarism & Grantmaking | $2.0M | $66.5M |
| 53 | Robert and Joan Follett Memorial Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $2.0M | $1.8M |
| 54 | Fox Valley Humane Association | Animal-Related | $1.9M | $2.9M |
| 55 | Hartwig Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.9M | $7.9M |
| 56 | Catalysis INC | Health Care | $1.8M | $1.3M |
| 57 | Project Bridges Day Care Center and Preschool INC | Human Services | $1.8M | $493K |
| 58 | Fox-wolf Watershed Alliance INC | Science & Technology | $1.7M | $1.1M |
| 59 | Old Glory Honor Flight INC | Public & Societal Benefit | $1.7M | $2.8M |
| 60 | Geoff and Kelly Crowley Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.6M | $3.7M |
| 61 | Midwest Growth INC | Community Improvement & Capacity Building | $1.5M | $48K |
| 62 | Family Training Program INC | Human Services | $1.4M | $362K |
| 63 | Betty a Lewis Environmental Charitable Tr | Environment | $1.3M | $2.8M |
| 64 | Riverview Gardens INC | Environment | $1.3M | $5.7M |
| 65 | Kenya Works INC | Education | $1.3M | $133K |
| 66 | Cots INC | Housing & Shelter | $1.3M | $3.3M |
| 67 | African Heritage INC | Arts, Culture & Humanities | $1.2M | $791K |
| 68 | Blazing Hearts | Recreation & Sports | $1.1M | $185K |
| 69 | Nami Fox Valley INC | Unclassified | $1.1M | $2.2M |
| 70 | Soar Fox Cities INC | Human Services | $1.1M | $1.9M |
| 71 | International Brotherhood of Electrical Workers | Unclassified | $1.1M | $2.5M |
| 72 | Respite Care Association of Wisconsin INC | Human Services | $1.1M | $256K |
| 73 | Appleton Downtown INC | Unclassified | $1.1M | $772K |
| 74 | Celebration Lutheran School INC | Unclassified | $1.1M | $63K |
| 75 | Faith Child Care INC | Human Services | $1.0M | $831K |
| 76 | Fox Valley Cooperative Farm Management Association | Unclassified | $1.0M | $1.4M |
| 77 | Wisconsin State Alliance of Ymcas | Youth Development | $1.0M | $820K |
| 78 | Appleton Ice INC | Recreation & Sports | $970K | $3.1M |
| 79 | St. Vincent de Paul Society of Appleton INC | Unclassified | $965K | $2.4M |
| 80 | Appleton Yacht Club | Unclassified | $947K | $1.6M |
| 81 | Appleton Cemetery Association | Unclassified | $934K | $5.4M |
| 82 | Valley Kids Foundation INC | Human Services | $919K | $1.7M |
| 83 | Doug & Carla Salmon Foundation INC | Philanthropy, Voluntarism & Grantmaking | $883K | $982K |
| 84 | Fox Cities Racquet Club INC | Recreation & Sports | $848K | $1.7M |
| 85 | St. Francis Xavier Catholic School System Foundation INC | Unclassified | $844K | $8.9M |
| 86 | The Clarence Wallace and Dolores Lynch Wallace Family Foundation | Philanthropy, Voluntarism & Grantmaking | $843K | $6.3M |
| 87 | International Association of Agricultural Economists INC | Community Improvement & Capacity Building | $826K | $1.3M |
| 88 | Hetzel-long Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $822K | $3.0M |
| 89 | Fox Cities Amateur Sports Authority | Education | $802K | $3.5M |
| 90 | Music That Matters INC | Arts, Culture & Humanities | $790K | $1.4M |
| 91 | Ryan Community INC | Crime & Legal-Related | $787K | $129K |
| 92 | Boldt Family Fund INC | Philanthropy, Voluntarism & Grantmaking | $782K | $4.1M |
| 93 | Fox Valley Symphony Orchestra Association INC | Unclassified | $745K | $1.2M |
| 94 | Aylward Family Foundation INC | Unclassified | $744K | $5.5M |
| 95 | Mechanical Contractors Association of N Central Wi Industry Fund | Unclassified | $738K | $827K |
| 96 | Wisconsin Veterans Village Association INC | Housing & Shelter | $734K | $5.6M |
| 97 | People of Progression INC | Arts, Culture & Humanities | $720K | $415K |
| 98 | Conference on Language Modeling INC | Social Science | $712K | $393K |
| 99 | Gordon Bubolz Nature Preserve INC | Unclassified | $708K | $6.0M |
| 100 | Fox Valley Literacy Council INC | Human Services | $690K | $1.2M |