| 1 | Liberty University INC | Education | $2.4B | $4.6B |
| 2 | Centra Health INC | Health Care | $1.2B | $1.5B |
| 3 | University of Lynchburg | Education | $251.9M | $258.8M |
| 4 | Randolph College | Education | $43.9M | $284.4M |
| 5 | Paul Shelton Hcsr | Human Services | $38.7M | $147.4M |
| 6 | Presbyterian Homes & Family Services INC | Human Services | $25.9M | $44.0M |
| 7 | Liberty Christian Academy | Unclassified | $22.9M | $19.6M |
| 8 | The Al Stroobants Foundation | Unclassified | $22.6M | $41.6M |
| 9 | Greater Lynchburg Community Foundation | Philanthropy, Voluntarism & Grantmaking | $20.1M | $75.7M |
| 10 | Virginia University of Lynchburg INC | Unclassified | $14.4M | $26.1M |
| 11 | Community Access Network INC | Health Care | $13.8M | $4.0M |
| 12 | Spring Hill Cemetery Association | Unclassified | $9.8M | $17.3M |
| 13 | Lynchburg South Lodge No 1727 Loyal Order of the Moose | Unclassified | $8.4M | $4.2M |
| 14 | Patrick Henry Family Services INC | Human Services | $8.1M | $65.6M |
| 15 | Boonsboro Country Club Corp. | Unclassified | $7.9M | $9.0M |
| 16 | Centra Health Foundation | Health Care | $6.8M | $82.8M |
| 17 | Virginia Legal Aid Society INC | Crime & Legal-Related | $6.1M | $4.7M |
| 18 | Easley Char Irr Tua 5019004715 | Unclassified | $6.0M | $9.8M |
| 19 | Academy Center of the Arts INC | Arts, Culture & Humanities | $5.7M | $41.7M |
| 20 | Patrick Henry Family Services Operations INC | Human Services | $5.5M | $617K |
| 21 | Lynchburg Humane Society INC | Animal-Related | $5.3M | $13.4M |
| 22 | James River Day School INC | Unclassified | $4.7M | $7.2M |
| 23 | Central Virginia Alliance for Community Living INC | Human Services | $4.6M | $3.5M |
| 24 | Williams Home Incorporated | Unclassified | $4.4M | $33.7M |
| 25 | Lynchburg Community Action Group INC | Unclassified | $4.4M | $1.3M |
| 26 | Sports Outreach Institute INC | Human Services | $4.2M | $396K |
| 27 | Lynchburg Sheltered Industries INC | Employment | $4.0M | $2.9M |
| 28 | Farrr Foundation | Philanthropy, Voluntarism & Grantmaking | $3.6M | $5.2M |
| 29 | Miriams House INC | Housing & Shelter | $3.5M | $7.2M |
| 30 | Park View Community Mission INC | Human Services | $3.4M | $2.4M |
| 31 | Horizon Opportunities INC | Health Care | $3.0M | $10.8M |
| 32 | Elizabeths Early Learning Center INC | Human Services | $2.9M | $10.8M |
| 33 | Arc of Central Virginia | Unclassified | $2.9M | $2.4M |
| 34 | Habitat for Humanity International INC | Housing & Shelter | $2.6M | $4.4M |
| 35 | Meals on Wheels | Unclassified | $2.0M | $6.1M |
| 36 | New Century Foundation | Employment | $2.0M | $2.4M |
| 37 | YWCA of Central Virginia | Human Services | $2.0M | $3.3M |
| 38 | Central Virginia Community College Educational Foundation INC | Education | $2.0M | $7.0M |
| 39 | New Vistas School of Central Virginia INC | Education | $1.9M | $3.6M |
| 40 | Amazement Square | Arts, Culture & Humanities | $1.9M | $7.2M |
| 41 | Schewel Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $1.8M | $5.9M |
| 42 | United Way of Central Virginia INC | Unclassified | $1.8M | $2.0M |
| 43 | Lynchburg Daily Bread INC | Food, Agriculture & Nutrition | $1.7M | $2.8M |
| 44 | Virginia Association of School Superintendents | Unclassified | $1.7M | $1.6M |
| 45 | Godly Response to Abuse in the Christian Environment | Crime & Legal-Related | $1.6M | $599K |
| 46 | Lynchburg Regional Business Alliance | Unclassified | $1.6M | $3.8M |
| 47 | Lynchburg Lodge 715 Loyal Order of Moose | Unclassified | $1.6M | $1.0M |
| 48 | Rush Homes INC | Housing & Shelter | $1.5M | $5.7M |
| 49 | Riverviews | Arts, Culture & Humanities | $1.5M | $1.9M |
| 50 | Lynchburg Beacon of Hope | Education | $1.5M | $5.9M |
| 51 | Roads to Recovery INC | Mental Health & Crisis Intervention | $1.5M | $2.2M |
| 52 | Blue Ridge Montessori INC | Education | $1.4M | $212K |
| 53 | Piedmont Orthopedic Foundation | Medical Research | $1.4M | $3.0M |
| 54 | Free Clinic of Central Va INC | Health Care | $1.4M | $1.6M |
| 55 | Lynchburg Covenant Fellowship INC | Unclassified | $1.4M | $6.7M |
| 56 | National Alliance for Childrens Grief | Human Services | $1.3M | $2.3M |
| 57 | H C Housing INC | Unclassified | $1.2M | $2.5M |
| 58 | The Westminster Canterbury of Lynchburg Foundation INC | Housing & Shelter | $1.2M | $11.8M |
| 59 | Jubilee Family Development Center INC | Recreation & Sports | $1.2M | $2.5M |
| 60 | Julies Heartcry Incorporated | Human Services | $1.1M | $87K |
| 61 | George M Jones Library Association | Unclassified | $1.1M | $4.7M |
| 62 | Kula Project INC | Environment | $1.1M | $558K |
| 63 | Blue Ridge Pregnancy Center | Health Care | $1.1M | $2.6M |
| 64 | American Legion | Unclassified | $979K | $1.6M |
| 65 | Auxiliary to Lynchburg General Hospital INC | Unclassified | $950K | $106K |
| 66 | Allow the Children INC | Religion-Related | $831K | $1.6M |
| 67 | Awareness Garden | Environment | $819K | $2.0M |
| 68 | Miller Home of Lynchburg Va | Unclassified | $787K | $1.0M |
| 69 | Lynchburg Grows | Youth Development | $776K | $1.7M |
| 70 | Camp Bahamas Missions Cbm INC | Religion-Related | $766K | $48K |
| 71 | Branches Academy and Early Learning Center INC | Education | $753K | $62K |
| 72 | Darst Vermillion Foundation | Education | $729K | $1.7M |
| 73 | Bethune Nursery School INC | Unclassified | $728K | $1.3M |
| 74 | Casa of Central Virginia INC | Civil Rights, Social Action & Advocacy | $723K | $690K |
| 75 | Liberty University Foundation | Education | $712K | $89K |
| 76 | Virginia Amateur Sports INC | Recreation & Sports | $681K | $75K |
| 77 | Central Virginia Governors School Foundation | Unclassified | $678K | $5.3M |
| 78 | Lyn-dan Heights Volunteer Fire Dept | Public Safety, Disaster Preparedness & Relief | $677K | $876K |
| 79 | John K Henne Charitable Trust | Unclassified | $659K | $1.5M |
| 80 | M4k Lynchburg INC | Youth Development | $653K | $13K |
| 81 | Child Development Center at Timberlake | Human Services | $640K | $45K |
| 82 | Association of Consulting Foresters of America INC | Unclassified | $630K | $824K |
| 83 | City of Lynchburg Police Foundation INC | Crime & Legal-Related | $611K | $658K |
| 84 | Opera on the James | Arts, Culture & Humanities | $609K | $1.7M |
| 85 | Freedom 4-24 | International, Foreign Affairs & National Security | $589K | $188K |
| 86 | Interfaith Outreach Association | Religion-Related | $582K | $1.3M |
| 87 | United States Bowling Congress INC | Recreation & Sports | $570K | $105K |
| 88 | Global Camps Africa INC | Recreation & Sports | $567K | $491K |
| 89 | Lynchburg Museum Foundation | Philanthropy, Voluntarism & Grantmaking | $548K | $1.3M |
| 90 | Central Virginia Volleyball Incorporated | Recreation & Sports | $533K | $94K |
| 91 | Rhemas Gentle Care Child Development Center | Community Improvement & Capacity Building | $525K | $308K |
| 92 | The Lynchburg Public Schools Education Foundation INC | Unclassified | $491K | $1.0M |
| 93 | Art Jewelry Forum | Arts, Culture & Humanities | $490K | $563K |
| 94 | Sitting Well at the Well INC | Mental Health & Crisis Intervention | $487K | $29K |
| 95 | Presbyterian Cemetery of the City of Lynchburg | Unclassified | $485K | $451K |
| 96 | Lynchburg Symphony Orchestra INC | Arts, Culture & Humanities | $477K | $198K |
| 97 | Camp Kum-ba-yah INC | Recreation & Sports | $471K | $2.4M |
| 98 | Road Runners Club of America | Unclassified | $455K | $227K |
| 99 | Boys & Girls Club of Greater Lynchburg | Youth Development | $452K | $1.2M |
| 100 | Vector Space | Arts, Culture & Humanities | $439K | $1.5M |