| 1 | Mother Frances Hospital Regional Health Care Center | Health Care | $1.4B | $853.3M |
| 2 | Christus Trinity Clinic Texas | Health Care | $1.1B | $107.7M |
| 3 | Health Foundation of East Texas | Philanthropy, Voluntarism & Grantmaking | $268.6M | $173.0M |
| 4 | Regional East Texas Food Bank | Unclassified | $77.7M | $39.9M |
| 5 | East Texas Lighthouse for the Blind INC | Unclassified | $46.5M | $61.3M |
| 6 | East Texas Communties Foundation INC | Philanthropy, Voluntarism & Grantmaking | $45.3M | $129.5M |
| 7 | Ben and Maytee Fisch Foundation | Philanthropy, Voluntarism & Grantmaking | $39.7M | $76.5M |
| 8 | Bob L Herd Foundation | Unclassified | $30.0M | $32.8M |
| 9 | Cumberland Academy | Unclassified | $24.7M | $95.4M |
| 10 | The Rogers Foundation | Unclassified | $23.5M | $34.2M |
| 11 | The Caldwell Foundation | Philanthropy, Voluntarism & Grantmaking | $23.1M | $116.1M |
| 12 | Tyler Family Circle of Care | Health Care | $22.4M | $24.3M |
| 13 | Continuecare Hospital of Tyler Incorporated | Health Care | $21.3M | $8.7M |
| 14 | Hospice of East Texas | Unclassified | $21.2M | $28.2M |
| 15 | Bethesda Health Clinic | Health Care | $21.0M | $17.8M |
| 16 | Texas College | Education | $19.2M | $67.3M |
| 17 | Dew Foundation | Philanthropy, Voluntarism & Grantmaking | $15.7M | $37.0M |
| 18 | Goodwill Industries of East Texas INC | Employment | $15.1M | $22.2M |
| 19 | Willowbrook Country Club | Unclassified | $11.2M | $11.5M |
| 20 | Meadow Lake LLC | Human Services | $11.1M | $40.6M |
| 21 | Tyler Junior College Foundation | Education | $10.6M | $120.6M |
| 22 | The Mentoring Alliance | Youth Development | $9.7M | $10.0M |
| 23 | R W Fair Foundation | Unclassified | $9.0M | $25.6M |
| 24 | Watson W Wise Foundation | Unclassified | $8.0M | $23.3M |
| 25 | Riter Family Foundation | Philanthropy, Voluntarism & Grantmaking | $7.5M | $13.2M |
| 26 | Cooperative Teachers Credit Union | Unclassified | $7.2M | $102.7M |
| 27 | Louis and Peaches Owen Family Foundation | Philanthropy, Voluntarism & Grantmaking | $6.3M | $13.9M |
| 28 | Educational Radio Foundation of East Texas INC | Arts, Culture & Humanities | $5.9M | $20.1M |
| 29 | Childrens Advocacy Center of Smith County | Crime & Legal-Related | $5.4M | $12.1M |
| 30 | James I Perkins Family Foundation | Philanthropy, Voluntarism & Grantmaking | $4.4M | $37.9M |
| 31 | Texas Palliative Care | Health Care | $4.3M | $597K |
| 32 | Hospice of East Texas Foundation | Health Care | $4.1M | $17.4M |
| 33 | Julietta Jarvis Foundation INC | Unclassified | $4.1M | $12.6M |
| 34 | Handup Network | Human Services | $4.1M | $3.0M |
| 35 | Meals on Wheels Ministry INC | Food, Agriculture & Nutrition | $3.9M | $2.3M |
| 36 | Azleway INC | Human Services | $3.9M | $3.5M |
| 37 | Literacy Council of Tyler INC | Education | $3.7M | $4.0M |
| 38 | Path People Attempting to Help | Human Services | $3.6M | $7.6M |
| 39 | Lowery Family Foundation | Philanthropy, Voluntarism & Grantmaking | $3.6M | $6.9M |
| 40 | Habitat for Humanity International INC | Housing & Shelter | $3.5M | $2.8M |
| 41 | East Texas Crisis Center INC | Human Services | $3.3M | $4.4M |
| 42 | County Rehabilitation Center INC | Mental Health & Crisis Intervention | $3.3M | $1.5M |
| 43 | Greater East Texas Certified Development Corporation | Unclassified | $3.2M | $2.8M |
| 44 | National Foundation for Rescued Animals | Animal-Related | $3.1M | $5.4M |
| 45 | East Texas Mental Health Incorporated | Health Care | $3.0M | $12.4M |
| 46 | Illges-chenoweth Foundation INC | Unclassified | $3.0M | $2.3M |
| 47 | Mosaic Counseling Centers of East Texas INC | Mental Health & Crisis Intervention | $2.9M | $4.4M |
| 48 | Piney Woods Regional Advisory Council | Health Care | $2.8M | $864K |
| 49 | Dr and Mrs J E Watkins Scholarship Trust | Unclassified | $2.8M | $11.2M |
| 50 | Tyler Catholic School Foundation | Unclassified | $2.6M | $5.4M |
| 51 | Clements Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.5M | $16.5M |
| 52 | United Way of Tyler-smith County | Philanthropy, Voluntarism & Grantmaking | $2.4M | $6.3M |
| 53 | Next Step Community Solutions | Mental Health & Crisis Intervention | $2.4M | $465K |
| 54 | Sam Roosth Foundation | Unclassified | $2.3M | $8.6M |
| 55 | East Texas Veterans Community Council | Public & Societal Benefit | $2.2M | $5.1M |
| 56 | Tyler Chamber of Commerce | Unclassified | $2.1M | $1.7M |
| 57 | Kings Academy Christian School | Education | $2.1M | $417K |
| 58 | Tyler Economic Development Council | Community Improvement & Capacity Building | $2.1M | $12.2M |
| 59 | Tyler Museum of Art | Arts, Culture & Humanities | $2.1M | $5.9M |
| 60 | SPCA of East Texas | Animal-Related | $2.0M | $7.3M |
| 61 | Keystone Credit Union | Unclassified | $2.0M | $39.7M |
| 62 | Park of East Texas INC | Recreation & Sports | $2.0M | $6.6M |
| 63 | Better Buisness Bureau of Central East Texas INC | Unclassified | $1.9M | $1.5M |
| 64 | Tapkard INC | Crime & Legal-Related | $1.9M | $1.8M |
| 65 | Jackson Water Supply Corporation | Unclassified | $1.8M | $3.6M |
| 66 | East Texas Food Bank Foundation INC | Food, Agriculture & Nutrition | $1.8M | $4.1M |
| 67 | Anderson-vukelja Foundation | Philanthropy, Voluntarism & Grantmaking | $1.7M | $3.9M |
| 68 | Tyler City Employees Credit Union | Unclassified | $1.7M | $28.3M |
| 69 | Church Missions Network | Religion-Related | $1.7M | $205K |
| 70 | A S Genecov Foundation | Unclassified | $1.6M | $7.6M |
| 71 | Dean Water Supply Corporation | Unclassified | $1.5M | $4.1M |
| 72 | United Credit Union | Unclassified | $1.4M | $28.5M |
| 73 | Boy Scouts of America | Unclassified | $1.4M | $1.3M |
| 74 | Tyler Area Builders Association | Unclassified | $1.4M | $1.2M |
| 75 | Civitan International | Unclassified | $1.4M | $44K |
| 76 | Marvin United Methodist Church Foundation INC | Religion-Related | $1.3M | $4.2M |
| 77 | Casa for Kids of East Texas INC | Civil Rights, Social Action & Advocacy | $1.3M | $2.8M |
| 78 | Texas Rose Festival Association | Unclassified | $1.3M | $810K |
| 79 | Journeys of the Heart INC | Youth Development | $1.2M | $57K |
| 80 | East Texas Symphony Orchestra | Arts, Culture & Humanities | $1.2M | $4.7M |
| 81 | Green Acres Baptist Church Foundation | Religion-Related | $1.2M | $13.5M |
| 82 | East Texas Orphan Care Network INC | Human Services | $1.1M | $1.4M |
| 83 | Sand Flat Water Supply Corporation | Unclassified | $1.1M | $3.7M |
| 84 | Texas Wounded Warriors | Public & Societal Benefit | $1.1M | $2.0M |
| 85 | Hibbs Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.1M | $3.1M |
| 86 | Greater Tyler Association of Realtors INC | Unclassified | $1.1M | $6.4M |
| 87 | Tyler Day Nursery Association | Human Services | $1.1M | $2.5M |
| 88 | Saleh Foundation | Human Services | $1.0M | $1.4M |
| 89 | Promise Academy | Education | $946K | $989K |
| 90 | Gloria Dei Foundation INC | Philanthropy, Voluntarism & Grantmaking | $934K | $3.3M |
| 91 | Living Alternatives INC | Human Services | $930K | $3.3M |
| 92 | The Discovery Science Place INC | Arts, Culture & Humanities | $924K | $2.3M |
| 93 | Smith County Champions for Children INC | Education | $906K | $227K |
| 94 | Cumberland Leadership Academy | Education | $903K | $121K |
| 95 | National Associates of Long Term Hospitals INC | Unclassified | $898K | $860K |
| 96 | Junior League of Tyler INC | Community Improvement & Capacity Building | $874K | $1.8M |
| 97 | Hoeffner Foundation | Philanthropy, Voluntarism & Grantmaking | $867K | $3.6M |
| 98 | Kourage Health INC | Diseases, Disorders & Medical Disciplines | $843K | $4.5M |
| 99 | Alzheimers Alliance of Northeast Texas INC | Unclassified | $836K | $2.8M |
| 100 | North Tyler Day Nursery INC | Unclassified | $823K | $1.2M |