| 1 | Lower Rio Grande Valley Work Force Development Board INC | Employment | $100.3M | $12.2M |
| 2 | Food Bank of the Rio Grande Valley INC | Unclassified | $51.8M | $25.5M |
| 3 | Affordable Homes of South Texas INC | Housing & Shelter | $19.6M | $114.8M |
| 4 | Easter Seals Rio Grande Valley | Health Care | $16.0M | $6.2M |
| 5 | Student Alternatives Program Incorporated | Education | $16.0M | $24.1M |
| 6 | The University of Texas Rio Grande Valley Foundation | Unclassified | $14.4M | $46.9M |
| 7 | Access Esperanza Clinics INC | Health Care | $10.7M | $14.3M |
| 8 | McAllen Country Club INC | Unclassified | $9.0M | $12.2M |
| 9 | McAllen Economic Development Corporation | Unclassified | $6.5M | $31.3M |
| 10 | Geo-son Child Care Services INC | Human Services | $6.5M | $654K |
| 11 | World Radio Network INC | Arts, Culture & Humanities | $6.1M | $9.2M |
| 12 | Boys and Girls Club of McAllen INC | Unclassified | $5.9M | $7.7M |
| 13 | Lower Rio Grande Valley Community Health Management Corporation INC | Health Care | $5.1M | $3.9M |
| 14 | McAllen International Museum | Arts, Culture & Humanities | $3.8M | $1.8M |
| 15 | McAllen Chamber of Commerce INC | Unclassified | $3.4M | $3.5M |
| 16 | Rio Grande Valley Communications Group | Public Safety, Disaster Preparedness & Relief | $2.9M | $9.6M |
| 17 | Covenant Christian Academy | Education | $2.8M | $5.1M |
| 18 | McAllen Housing Facility Corporation | Unclassified | $2.7M | $13.6M |
| 19 | Ssa Foundation | Philanthropy, Voluntarism & Grantmaking | $2.6M | $11.3M |
| 20 | Greater McAllen Association of Realtors INC | Unclassified | $2.3M | $3.4M |
| 21 | Vannie E Cook Jr Cancer Foundation INC | Unclassified | $2.3M | $16.3M |
| 22 | United Way of South Texas | Philanthropy, Voluntarism & Grantmaking | $2.2M | $5.3M |
| 23 | Communities in Schools of Hidalgo-willacy Counties INC | Unclassified | $2.2M | $4.9M |
| 24 | Rgv Inclusive Project INC | Housing & Shelter | $2.1M | $3.4M |
| 25 | The Door Christian Church of McAllen Texas INC | Religion-Related | $2.0M | $4.8M |
| 26 | La Casa de Dios INC | Unclassified | $1.9M | $74K |
| 27 | Solaris Foundation | Unclassified | $1.9M | $6.3M |
| 28 | Women Together Foundation INC | Human Services | $1.9M | $1.4M |
| 29 | Make-a-wish Foundation of the Rio Grande Valley | Human Services | $1.7M | $1.6M |
| 30 | McAllen Area Economic Development Corporation | Community Improvement & Capacity Building | $1.6M | $735K |
| 31 | American Legion | Unclassified | $1.6M | $241K |
| 32 | Rio Grande Habitat for Humanity | Unclassified | $1.5M | $1.9M |
| 33 | Stars Scholarship Fund | Education | $1.4M | $617K |
| 34 | Faith Ministry Ministerio de Fe | Religion-Related | $1.3M | $1.6M |
| 35 | Texas International Fishing Tournament INC | Unclassified | $1.3M | $167K |
| 36 | Rio Bravo Ministries | Religion-Related | $1.2M | $226K |
| 37 | Community Hope Projects INC | Philanthropy, Voluntarism & Grantmaking | $1.2M | $2.2M |
| 38 | Trucha | Arts, Culture & Humanities | $1.2M | $842K |
| 39 | Rio Grande Valley Gme Consortium | Health Care | $1.0M | $10K |
| 40 | Mision Isaias 55 INC | Religion-Related | $1.0M | $495K |
| 41 | International Brotherhood of Electrical Workers | Unclassified | $939K | $681K |
| 42 | National Network of Abortion Funds | Environment | $939K | $2.7M |
| 43 | McAllen Pregnancy Center | Education | $922K | $4.0M |
| 44 | Camp University | Education | $914K | $2.0M |
| 45 | South Texas Symphony Association INC | Arts, Culture & Humanities | $903K | $690K |
| 46 | Improved Order of Red Men of Texas | Unclassified | $881K | $2K |
| 47 | South Texas Youth Soccer Association | Unclassified | $871K | $327K |
| 48 | South Texas Community College Education Foundation | Education | $846K | $498K |
| 49 | Challenged Sportsmen of America INC | Recreation & Sports | $840K | $66K |
| 50 | Rgv Low Cost Spay Neuter Clinic | Animal-Related | $839K | $136K |
| 51 | Valley Land Fund INC | Environment | $792K | $4.4M |
| 52 | Valley Alliance of Mentors for | Education | $786K | $1.2M |
| 53 | Improved Order of Red Men of Texas | Unclassified | $724K | $783 |
| 54 | International Bariatric Club | Medical Research | $603K | $544K |
| 55 | Rio Grande Valley-laredo Electrical Jatc Tr Fund | Unclassified | $597K | $861K |
| 56 | McAllen Housing Development Corporation | Housing & Shelter | $593K | $3.3M |
| 57 | McAllen Federation of Teachers | Employment | $593K | $46K |
| 58 | Friends of Quinta Mazatlan | Environment | $549K | $621K |
| 59 | Comfort House Services INC | Religion-Related | $530K | $594K |
| 60 | South Texas Juvenile Diabetes Association | Health Care | $527K | $418K |
| 61 | Auxiliary to South Texas Health System INC | Education | $525K | $546K |
| 62 | Divine Children INC | Health Care | $429K | $1.8M |
| 63 | Amistad McAllen | Religion-Related | $428K | $1.9M |
| 64 | James W and Kathleen C Collins Family Foundation | Education | $409K | $5.9M |
| 65 | Gonzalez Elementary Parent Teacher Organization | Education | $407K | $187K |
| 66 | South Texas Builders Alliance | Community Improvement & Capacity Building | $391K | $107K |
| 67 | Angels of Love | Human Services | $374K | $86K |
| 68 | Rgv Hispanic Chamber of Commerce | Community Improvement & Capacity Building | $374K | $100K |
| 69 | Our Lady of Sorrows School Endowment Fund | Unclassified | $371K | $2.3M |
| 70 | Capable Kids Foundation INC | Human Services | $366K | $110K |
| 71 | Rio Grande Valley Community Foundation | Recreation & Sports | $336K | $614K |
| 72 | Rio Grande Valley Diabetesassociation | Health Care | $336K | $328K |
| 73 | Keep McAllen Beautiful INC | Unclassified | $321K | $121K |
| 74 | Benevolent & Protective Order of Elks of the USA | Unclassified | $302K | $669K |
| 75 | Cook Dalton Family Foundation | Education | $300K | $4.7M |
| 76 | Seven Cities Foundation | Philanthropy, Voluntarism & Grantmaking | $290K | $2.6M |
| 77 | McAllen Education Foundation INC | Philanthropy, Voluntarism & Grantmaking | $279K | $172K |
| 78 | Morris PTO | Public & Societal Benefit | $267K | $135K |
| 79 | McAllen Heritage Center INC | Arts, Culture & Humanities | $256K | $261K |
| 80 | Christian Fellowship Union INC | Religion-Related | $255K | $220K |
| 81 | Servants of the Cross | Unclassified | $253K | $1.5M |
| 82 | The Palmer Drug Abuse Program McAllen INC | Mental Health & Crisis Intervention | $246K | $242K |
| 83 | La Piedad Cemetery Association | Mutual & Membership Benefit | $229K | $2.5M |
| 84 | Service Over Self Sos Foundation of the Rotary Club of Edinburg | Human Services | $218K | $1.2M |
| 85 | Texas Festival and Events Association | Community Improvement & Capacity Building | $215K | $323K |
| 86 | Shrink Box INC | Mental Health & Crisis Intervention | $215K | $0 |
| 87 | Dentists Who Care INC | Human Services | $198K | $150K |
| 88 | Hidalgo-starr Counties Medical Society | Unclassified | $194K | $883K |
| 89 | Rio Grande Valley Builders Association INC | Unclassified | $187K | $50K |
| 90 | International Association of Fire Fighters | Employment | $185K | $471K |
| 91 | Msa Lone Star Council | Religion-Related | $179K | $23K |
| 92 | McAllen Industrial Foundation INC | Unclassified | $171K | $2.3M |
| 93 | Klinck Foundation INC | Unclassified | $168K | $1.2M |
| 94 | Junior League of McAllen INC | Community Improvement & Capacity Building | $160K | $507K |
| 95 | Texas Watermelon Association INC | Unclassified | $159K | $293K |
| 96 | McAllen Crime Stoppers INC | Crime & Legal-Related | $156K | $84K |
| 97 | Gentex | Civil Rights, Social Action & Advocacy | $155K | $162K |
| 98 | Workforce Leadership of Texas | Education | $149K | $108K |
| 99 | Hidalgo County Sheriffs Community Foundation | Public Safety, Disaster Preparedness & Relief | $149K | $86K |
| 100 | McHi Quarterback Booster | Youth Development | $143K | $127K |