| 1 | Chronic Disease Fund INC | Health Care | $656.2M | $220.6M |
| 2 | Texas Health Hospital Frisco | Health Care | $196.6M | $288.0M |
| 3 | Professional Golfers Association of America | Unclassified | $169.0M | $535.5M |
| 4 | Legacy Christian Academy | Education | $40.4M | $57.6M |
| 5 | National Breast Cancer Foundation INC | Health Care | $30.0M | $26.3M |
| 6 | United States Youth Soccer | Recreation & Sports | $21.4M | $24.1M |
| 7 | Hkgk Krishnan Foundation | Education | $21.2M | $26.0M |
| 8 | Insight for Living | Religion-Related | $21.0M | $23.9M |
| 9 | East Broadcasting Company | Religion-Related | $19.8M | $20.5M |
| 10 | Datta Yoga Center | Unclassified | $18.0M | $62.2M |
| 11 | Pga Foundation INC | Unclassified | $16.4M | $6.0M |
| 12 | Leadership Prep School | Education | $14.0M | $29.8M |
| 13 | Visa Vel Foundation | Environment | $11.3M | $13.7M |
| 14 | Preethi Mani Foundation | Education | $11.2M | $13.5M |
| 15 | Gene and Jerry Jones Family-dallas Cowboys Charities | Philanthropy, Voluntarism & Grantmaking | $9.2M | $3.4M |
| 16 | Master Cares Foundation INC | Human Services | $7.9M | $2.3M |
| 17 | North Texas State Soccer Association INC | Unclassified | $7.6M | $6.9M |
| 18 | Kaleidoscope Park Foundation | Recreation & Sports | $7.5M | $27.7M |
| 19 | National Association of Government Guaranteed Lenders Naggl INC | Community Improvement & Capacity Building | $7.4M | $4.7M |
| 20 | K-ed Foundation | Philanthropy, Voluntarism & Grantmaking | $7.2M | $12.6M |
| 21 | Northern Texas Pga Foundation | Recreation & Sports | $6.9M | $14.3M |
| 22 | National Association for the Self Employed INC | Unclassified | $5.1M | $18.0M |
| 23 | Frisco Family Services Center | Human Services | $5.0M | $10.0M |
| 24 | North Texas State Soccer Association INC | Recreation & Sports | $5.0M | $6.5M |
| 25 | Restaurant Facility Management Association | Community Improvement & Capacity Building | $4.8M | $7.7M |
| 26 | All for His Glory Foundation | Philanthropy, Voluntarism & Grantmaking | $4.5M | $2.2M |
| 27 | Frisco Flyers Volleyball Club INC | Recreation & Sports | $4.3M | $804K |
| 28 | Southland Conference 070195 | Recreation & Sports | $4.3M | $8.6M |
| 29 | Northern Texas Section Professional Golfers Association of America INC | Unclassified | $3.8M | $1.5M |
| 30 | Dallas Stars Foundation INC | Education | $3.7M | $1.2M |
| 31 | Mark Terk Charitable Foundation | Community Improvement & Capacity Building | $3.7M | $20.7M |
| 32 | Frisco Tourism Public Improvement District Corporation | Community Improvement & Capacity Building | $3.6M | $3.8M |
| 33 | The Thomas Foundation | Philanthropy, Voluntarism & Grantmaking | $2.4M | $12.6M |
| 34 | Dallas Human Resource Management Association INC | Unclassified | $2.3M | $1.7M |
| 35 | Heritage Christian College Foundation USA | International, Foreign Affairs & National Security | $2.3M | $396K |
| 36 | Masters Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.1M | $6.0M |
| 37 | Foundation for Advanced Cardiovascular and Education Train | Mental Health & Crisis Intervention | $2.0M | $548K |
| 38 | Frisco Chamber of Commerce | Unclassified | $1.7M | $1.4M |
| 39 | Every Orphans Hope | Religion-Related | $1.7M | $140K |
| 40 | Brentwood Foundation | Unclassified | $1.6M | $695K |
| 41 | Frisco Education Foundation | Philanthropy, Voluntarism & Grantmaking | $1.6M | $5.7M |
| 42 | Nancy Lieberman Charities | Education | $1.6M | $2.3M |
| 43 | Grace Covenant Academy | Education | $1.4M | $124K |
| 44 | Cross Oak Ranch Homeowners Association INC | Housing & Shelter | $1.3M | $2.2M |
| 45 | Maher Foundation | Human Services | $1.3M | $1.5M |
| 46 | Nvgm Exploratory | Arts, Culture & Humanities | $1.3M | $3.5M |
| 47 | Sci-tech Discovery Center INC | Education | $1.2M | $672K |
| 48 | Amp Foundation | Philanthropy, Voluntarism & Grantmaking | $1.1M | $606K |
| 49 | Pga Financial Assistance Fund INC | Education | $1.1M | $8.8M |
| 50 | New Covenant Kg Foundation | Education | $993K | $2.5M |
| 51 | Baxley Foundation | Philanthropy, Voluntarism & Grantmaking | $977K | $1.8M |
| 52 | Museum of the American Railroad | Arts, Culture & Humanities | $972K | $5.4M |
| 53 | Golf Fore Charity INC | Human Services | $922K | $83K |
| 54 | Celebrity Games for Charity | Philanthropy, Voluntarism & Grantmaking | $895K | $781K |
| 55 | J & B Helping Hands | Education | $817K | $65K |
| 56 | Burning Limb Foundation | Diseases, Disorders & Medical Disciplines | $802K | $133K |
| 57 | Save the Child Foundation | Human Services | $747K | $123K |
| 58 | Soccer for Life INC | Recreation & Sports | $734K | $309K |
| 59 | Slc6a1 Connect | Medical Research | $717K | $2.4M |
| 60 | Elias & Sultana Foundation | Philanthropy, Voluntarism & Grantmaking | $637K | $7.0M |
| 61 | Gene and Jerry Jones Family Arlington Youth Foundation | Philanthropy, Voluntarism & Grantmaking | $621K | $2.8M |
| 62 | Security Industry Alarm Coalition | Community Improvement & Capacity Building | $595K | $439K |
| 63 | Frisco Student Fastpacs | Unclassified | $589K | $475K |
| 64 | Treasured Vessels Foundation | Human Services | $572K | $826K |
| 65 | Project Access-collin County | Community Improvement & Capacity Building | $557K | $309K |
| 66 | Wind International Foundation | Health Care | $546K | $581K |
| 67 | Parent Booster USA INC | Education | $515K | $33K |
| 68 | Hpa Hope Foundation | Human Services | $505K | $926K |
| 69 | Gita Mandir INC | Religion-Related | $494K | $2.3M |
| 70 | Global Renewal INC | Human Services | $475K | $696K |
| 71 | Hypoparathyroidism Association INC | Diseases, Disorders & Medical Disciplines | $458K | $258K |
| 72 | Slavic Reformation Society | Education | $452K | $141K |
| 73 | Telangana Peoples Association of Dallas | Arts, Culture & Humanities | $451K | $76K |
| 74 | New Orthodox Mission Church of North Dallas | Religion-Related | $451K | $436K |
| 75 | Miracle League of Frisco | Recreation & Sports | $451K | $633K |
| 76 | Caring Little Friends of St. Francis Preschool | Education | $451K | $103K |
| 77 | Great Commission Outreach | Health Care | $450K | $59K |
| 78 | Frisco Football League | Recreation & Sports | $427K | $28K |
| 79 | Magical Earth | Arts, Culture & Humanities | $412K | $407K |
| 80 | Gurughar INC | Religion-Related | $405K | $4.4M |
| 81 | Wakeland High School Band Boosters | Education | $405K | $208K |
| 82 | Nanban Foundation | Education | $402K | $129K |
| 83 | USA Springs of Hope Foundation INC | International, Foreign Affairs & National Security | $402K | $30K |
| 84 | Zeller Family Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $398K | $768K |
| 85 | Pathway Christian Preparatory Academy INC | Education | $393K | $115K |
| 86 | USA Hockey INC | Unclassified | $385K | $699K |
| 87 | Refresh Frisco | Human Services | $382K | $454K |
| 88 | Frisco Chamber Foundation | Philanthropy, Voluntarism & Grantmaking | $372K | $151K |
| 89 | Frisco Association for the Arts | Arts, Culture & Humanities | $371K | $62K |
| 90 | Lebanon Trail High School Band Booster Association | Education | $369K | $158K |
| 91 | International Fine Art Fund | Arts, Culture & Humanities | $368K | $5K |
| 92 | Lone Star High School Band Boosters Association | Youth Development | $360K | $131K |
| 93 | Africa Network Evangelism Task INC | Philanthropy, Voluntarism & Grantmaking | $359K | $1.6M |
| 94 | Operation Celebration INC | Human Services | $352K | $126K |
| 95 | Sgs Raga Sagara INC | Arts, Culture & Humanities | $348K | $248K |
| 96 | Coastal German Shepherd Rescue of Southern California a Public | Animal-Related | $343K | $1.8M |
| 97 | Global Hindu Heritage Foundation | Religion-Related | $339K | $378K |
| 98 | Sphoorti Foundation USA | International, Foreign Affairs & National Security | $339K | $635K |
| 99 | Hogar de la Promesa | International, Foreign Affairs & National Security | $337K | $105K |
| 100 | Affordable Home Living Foundation | Housing & Shelter | $335K | $261K |