| 1 | Driscoll Childrens Health Plan | Health Care | $1.2B | $436.0M |
| 2 | Driscoll Childrens Hospital | Health Care | $1.2B | $2.1B |
| 3 | Christus Spohn Health System Corporation | Health Care | $954.5M | $850.0M |
| 4 | Rally Credit Union | Unclassified | $332.3M | $4.5B |
| 5 | Ed Rachal Foundation | Religion-Related | $144.1M | $825.4M |
| 6 | Childrens Physician Services of South Texas | Health Care | $88.5M | $15.0M |
| 7 | South Texas Lighthouse for the Blind | Diseases, Disorders & Medical Disciplines | $58.1M | $40.8M |
| 8 | Driscoll Healthcare Services | Health Care | $55.6M | $1.9B |
| 9 | Coastal Bend Food Bank | Food, Agriculture & Nutrition | $53.3M | $70.3M |
| 10 | Goodwill Industries of South Texas INC | Unclassified | $38.1M | $51.7M |
| 11 | Coastal Bend Community Foundation | Philanthropy, Voluntarism & Grantmaking | $35.4M | $154.6M |
| 12 | John G & Marie Stella Kenedy Memorial Foundation | Religion-Related | $32.4M | $494.6M |
| 13 | Coastlife Credit Union | Unclassified | $29.3M | $495.6M |
| 14 | Una Chapman Cox Foundation | Public & Societal Benefit | $28.7M | $70.9M |
| 15 | Husky Owl Foundation | Philanthropy, Voluntarism & Grantmaking | $25.3M | $22.3M |
| 16 | Refinery Terminal Fire Company | Public Safety, Disaster Preparedness & Relief | $25.0M | $45.4M |
| 17 | Education Service Center Region II of Texas | Education | $24.9M | $29.8M |
| 18 | Driscoll Childrens Hospital Development Foundation INC | Philanthropy, Voluntarism & Grantmaking | $24.0M | $73.7M |
| 19 | Del Mar College Foundation INC | Philanthropy, Voluntarism & Grantmaking | $21.7M | $41.6M |
| 20 | Texas State Aquarium Association | Animal-Related | $19.2M | $93.7M |
| 21 | Nueces County Community Action Agency | Human Services | $18.3M | $6.4M |
| 22 | Coastal Bend Wellness Foundation INC | Diseases, Disorders & Medical Disciplines | $17.6M | $25.5M |
| 23 | Christus Spohn Health System Development Foundation | Health Care | $16.9M | $36.6M |
| 24 | Halo Flight INC | Unclassified | $16.5M | $47.1M |
| 25 | Coastal Bend Blood Center | Health Care | $14.6M | $28.3M |
| 26 | Coastal Bend Bays & Estuaries Program | Environment | $13.3M | $38.0M |
| 27 | Erf Real Estate Group | Community Improvement & Capacity Building | $12.9M | $137.0M |
| 28 | Gulf Coast Humane Society | Animal-Related | $11.4M | $12.1M |
| 29 | Texas a & M University-corpus Christi Foundation INC | Education | $11.2M | $62.0M |
| 30 | Mission of Mercy INC | Human Services | $10.6M | $5.5M |
| 31 | Allen Lovelace Moore and Blanche Davis Moore Foundation | Philanthropy, Voluntarism & Grantmaking | $10.4M | $7.8M |
| 32 | Members First Credit Union | Unclassified | $9.6M | $180.8M |
| 33 | Womens and Mens Health Services of the Coastal Bend INC | Health Care | $9.3M | $6.5M |
| 34 | Lady Lex Museum on the Bay Association | Arts, Culture & Humanities | $8.0M | $10.7M |
| 35 | Corpus Christi Country Club | Unclassified | $6.9M | $11.3M |
| 36 | United Way of the Coastal Bend INC | Philanthropy, Voluntarism & Grantmaking | $6.7M | $8.5M |
| 37 | Communities in Schools of the Coastal Bend | Education | $6.6M | $3.6M |
| 38 | Laverne and Thomas Howell Foundation | Philanthropy, Voluntarism & Grantmaking | $5.7M | $14.4M |
| 39 | Island Foundation INC | Education | $5.6M | $11.1M |
| 40 | Womens Shelter of South Texas | Unclassified | $5.5M | $4.8M |
| 41 | South Texas Institute for the Arts | Arts, Culture & Humanities | $5.4M | $14.5M |
| 42 | Ronald McDonald House Charities South Texas | Health Care | $5.2M | $14.9M |
| 43 | Buccaneer Commission INC Memorial Coliseum | Education | $5.2M | $3.8M |
| 44 | Texas Bridge Credit Union | Unclassified | $5.2M | $85.4M |
| 45 | Frazier Family Foundation INC | Human Services | $5.1M | $9.7M |
| 46 | Erf Real Estate INC | Community Improvement & Capacity Building | $5.0M | $142.0M |
| 47 | South Texas Substance Abuse Recovery Services INC | Mental Health & Crisis Intervention | $4.7M | $254K |
| 48 | Erf Real Estate INC | Community Improvement & Capacity Building | $4.7M | $15.9M |
| 49 | Contractors Safety Council of the Coastal Bend INC | Education | $4.7M | $24.7M |
| 50 | Coastal Bend Regional Advisory Council on Trauma Service Area U | Public Safety, Disaster Preparedness & Relief | $4.7M | $6.4M |
| 51 | Corpus Christi Yacht Club | Recreation & Sports | $4.0M | $4.6M |
| 52 | Star Financial Credit Union | Unclassified | $3.6M | $50.2M |
| 53 | Compassionate Care Medical Clinic | Health Care | $3.5M | $337K |
| 54 | Christian Education Activities Corp. | Education | $3.4M | $6.3M |
| 55 | Corpus Christi Pregnancy Center INC | Health Care | $3.2M | $3.6M |
| 56 | Bluebonnet Gardens | Housing & Shelter | $2.9M | $2.5M |
| 57 | Citizens for Educational Excellence INC | Education | $2.9M | $1.9M |
| 58 | The Morris L Lichtenstein Jr Medical Research Foundation | Philanthropy, Voluntarism & Grantmaking | $2.9M | $12.0M |
| 59 | Gulf Coast Council of la Raza | Human Services | $2.9M | $7.4M |
| 60 | Devary Durrill Foundation INC | Unclassified | $2.8M | $7.5M |
| 61 | Padre Isles Property Owners Assn. | Unclassified | $2.8M | $14.7M |
| 62 | South Texas Public Broadcasting System | Arts, Culture & Humanities | $2.7M | $7.2M |
| 63 | Coastal Bend Center for Independent Living | Human Services | $2.7M | $1.9M |
| 64 | First United Methodist Church of Corpus Christi Texas | Religion-Related | $2.7M | $7.6M |
| 65 | Corpus Christi Tourism Public Improvement District | Community Improvement & Capacity Building | $2.6M | $1.4M |
| 66 | Friends of the Corpus Christi Museum of Science and History | Arts, Culture & Humanities | $2.6M | $1.2M |
| 67 | Corpus Christi Area Convention and Tourist Bureau INC | Unclassified | $2.5M | $6.0M |
| 68 | Mary McLeod Bethune Early Child Development Nursery INC | Human Services | $2.4M | $2.1M |
| 69 | Agape Ranch | Unclassified | $2.4M | $6.6M |
| 70 | Triumph Over Kid Cancer Foundation | Diseases, Disorders & Medical Disciplines | $2.4M | $1.8M |
| 71 | Council on Alcohol and Drug Abuse Coastal Bend | Mental Health & Crisis Intervention | $2.3M | $1.0M |
| 72 | Corpus Christi Symphony Society INC | Arts, Culture & Humanities | $2.2M | $869K |
| 73 | Corpus Christi Area Council for the Deaf INC | Human Services | $2.1M | $967K |
| 74 | Behmann Brothers Foundation | Unclassified | $2.0M | $8.1M |
| 75 | Jewish Community Council of Corpus Christi | Human Services | $2.0M | $5.7M |
| 76 | Good Samaritan Rescue Mission | Human Services | $2.0M | $1.1M |
| 77 | Catholic Charities of Corpus Christi INC | Unclassified | $1.9M | $4.0M |
| 78 | P a a C People Assisting Animal Control | Animal-Related | $1.9M | $762K |
| 79 | Associated Builders & Contractors Merit Shop Training Program INC | Employment | $1.9M | $7.2M |
| 80 | United Corpus Christi Chamber of Commerce | Community Improvement & Capacity Building | $1.9M | $2.3M |
| 81 | Speck and Polly New Charitable Foundation Tr | Philanthropy, Voluntarism & Grantmaking | $1.8M | $6.6M |
| 82 | Stephens Charitable Foundation | Education | $1.8M | $2.0M |
| 83 | River Hills Country Club INC | Unclassified | $1.8M | $414K |
| 84 | Erf Real Estate INC | Community Improvement & Capacity Building | $1.7M | $61.1M |
| 85 | Foster Angels of South Texas Foundation | Human Services | $1.7M | $2.0M |
| 86 | International Brotherhood of Electrical Workers | Unclassified | $1.7M | $4.8M |
| 87 | Corpus Christi Metro Ministries | Human Services | $1.7M | $3.0M |
| 88 | Cattery INC | Animal-Related | $1.7M | $405K |
| 89 | Boys & Girls Clubs of the Coastal Bend INC | Unclassified | $1.7M | $4.9M |
| 90 | Childrens Advocacy Center of the Coastal Bend | Crime & Legal-Related | $1.7M | $833K |
| 91 | New Life Refuge Ministries | Human Services | $1.6M | $2.0M |
| 92 | Montessori Association of South Texas | Education | $1.6M | $1.2M |
| 93 | Dr and Mrs Hugh a Kennedy Foundation | Philanthropy, Voluntarism & Grantmaking | $1.6M | $11.3M |
| 94 | Estill Foundation | Unclassified | $1.5M | $5.5M |
| 95 | Corpus Christis Voice for Life | Civil Rights, Social Action & Advocacy | $1.5M | $25K |
| 96 | Neighborhood Centers of Corpus Christi Tex | Unclassified | $1.5M | $1.5M |
| 97 | Family Counseling Service | Human Services | $1.5M | $1.1M |
| 98 | Peewees Pet Adoption World & Sanctuary INC | Animal-Related | $1.5M | $2.4M |
| 99 | Little League Baseball INC | Unclassified | $1.5M | $248K |
| 100 | South Texas Botanical Gardens & Nature Center | Environment | $1.4M | $2.1M |