| 1 | The Samuel Roberts Noble Foundation | Philanthropy, Voluntarism & Grantmaking | $925.4M | $1.1B |
| 2 | Mercy Hospital Ardmore INC | Health Care | $202.6M | $95.2M |
| 3 | Noble Research Institute LLC | Education | $73.9M | $138.2M |
| 4 | Lighthouse Behavioral Wellness Centers INC | Mental Health & Crisis Intervention | $40.6M | $23.4M |
| 5 | Ardmore Insitiute of Health | Health Care | $25.8M | $114.0M |
| 6 | Jerome Westheimer Family Foundation | Unclassified | $18.0M | $40.1M |
| 7 | Southern Oklahoma Memorial Foundation INC | Religion-Related | $16.4M | $105.7M |
| 8 | Southern Oklahoma Regional Disposal INC | Public & Societal Benefit | $13.4M | $28.9M |
| 9 | Good Shepherd Community Clinic INC | Health Care | $13.3M | $13.4M |
| 10 | Southern Oklahoma Water Corporation | Unclassified | $12.5M | $24.7M |
| 11 | Cross Timbers Hospice INC | Human Services | $12.3M | $52.5M |
| 12 | Southern Oklahoma Ambulance Service INC | Health Care | $7.7M | $5.4M |
| 13 | Margaret Smith Weeks & Marie Stuart Smith Memorial Charitable Trust | Unclassified | $5.6M | $6.1M |
| 14 | Sunshine Industries INC | Employment | $5.5M | $20.7M |
| 15 | Glen Foundation INC | Unclassified | $4.9M | $1.7M |
| 16 | J Lyndall McCrory Robert Fulton McCrory & Montie Ray McCrory Foundation | Philanthropy, Voluntarism & Grantmaking | $4.2M | $23.3M |
| 17 | Community Youth Services of Southern Oklahoma INC | Unclassified | $4.0M | $16.3M |
| 18 | Mercy Health Foundation Ardmore | Unclassified | $3.8M | $8.9M |
| 19 | Community Foundation of Ardmore INC | Philanthropy, Voluntarism & Grantmaking | $3.4M | $15.0M |
| 20 | Charles B Goddard Center for Visual and Performing Arts INC | Arts, Culture & Humanities | $3.3M | $10.8M |
| 21 | Southern Oklahoma Library System Incorporated | Education | $3.3M | $9.0M |
| 22 | Dornick Hills Golf & Country Club INC | Unclassified | $3.0M | $4.1M |
| 23 | Oak Hall | Unclassified | $2.7M | $4.5M |
| 24 | Keith R and Robin a Gray Foundation INC | Unclassified | $2.5M | $1.8M |
| 25 | J Sylvester & Walter Lacy Mullen Memorial Charitable Trust B | Unclassified | $2.4M | $17.9M |
| 26 | C B Goddard Art Center Trust | Unclassified | $2.3M | $5.3M |
| 27 | Southwest Historical Foundation | Arts, Culture & Humanities | $2.2M | $11.2M |
| 28 | United Way of South Central Oklahoma INC | Unclassified | $1.9M | $2.9M |
| 29 | Anna Collins Franklin Foundation | Unclassified | $1.8M | $3.3M |
| 30 | Gloria Ainsworth Child Care & Learning Center INC | Human Services | $1.8M | $2.2M |
| 31 | Young Mens Christian Association of Ardmore Oklahoma | Human Services | $1.6M | $5.0M |
| 32 | Ardmore Animal Care INC | Animal-Related | $1.5M | $7.0M |
| 33 | Oklahoma Association for Retarded Citizens | Unclassified | $1.4M | $1.2M |
| 34 | Charles B Goddard Fdn Trust | Unclassified | $1.3M | $6.2M |
| 35 | Boy Scouts of America | Unclassified | $1.3M | $8.2M |
| 36 | Hfv Wilson Center Authority INC | Unclassified | $1.1M | $691K |
| 37 | Family Shelter of So Oklahoma Serv for Victims of Domestic Violence | Civil Rights, Social Action & Advocacy | $923K | $3.3M |
| 38 | Bilby Foundation | Philanthropy, Voluntarism & Grantmaking | $908K | $2.6M |
| 39 | Chamber of Commerce Foundation INC | Community Improvement & Capacity Building | $852K | $8.1M |
| 40 | Ardmore Chamber of Commerce INC | Unclassified | $751K | $1.0M |
| 41 | Ardmore Day Nursery INC | Human Services | $652K | $2.1M |
| 42 | Saras Project INC | Health Care | $604K | $845K |
| 43 | Margueritte B Piers Living Free Sanctuary for Animals and Nature | Recreation & Sports | $578K | $672K |
| 44 | Greater Southwest Historical Museum | Arts, Culture & Humanities | $540K | $1.7M |
| 45 | Community Activities INC of Ardmore | Human Services | $539K | $4.3M |
| 46 | Texoma Autism and Behavior Intervention School | Education | $530K | $368K |
| 47 | Equip Life Ministries | Religion-Related | $485K | $12K |
| 48 | Carter County Junior Livestock Show | Unclassified | $473K | $279K |
| 49 | Mance E & Fay Phillips Drummond Endowment Trust | Philanthropy, Voluntarism & Grantmaking | $436K | $1.8M |
| 50 | Ardmore Beautification Council INC | Environment | $425K | $3.1M |
| 51 | Ardmore Main Street Authority | Community Improvement & Capacity Building | $405K | $669K |
| 52 | Oklahoma Pharmacists Association | Unclassified | $402K | $675K |
| 53 | Clara McGowen Memorial Irrevocable Trust | Philanthropy, Voluntarism & Grantmaking | $397K | $893K |
| 54 | Benevolent & Protective Order of Elks of the USA | Unclassified | $386K | $138K |
| 55 | The More Foundation | Education | $386K | $501K |
| 56 | Food and Resource Center of South Central Oklahoma INC | Food, Agriculture & Nutrition | $375K | $1.7M |
| 57 | Kelley Foundation | Philanthropy, Voluntarism & Grantmaking | $365K | $647K |
| 58 | A Plus Reading INC | Education | $349K | $93K |
| 59 | Broadway House | Mental Health & Crisis Intervention | $300K | $629K |
| 60 | Outcasts Under Transformation INC | Unclassified | $297K | $493K |
| 61 | Carter County Casa INC | Civil Rights, Social Action & Advocacy | $281K | $590K |
| 62 | Shelter of His Wings Foundation | Human Services | $272K | $424K |
| 63 | Maria Hall Brantley and George Hall Brantley Endowment Trust | Philanthropy, Voluntarism & Grantmaking | $272K | $991K |
| 64 | Naomi House INC | Mental Health & Crisis Intervention | $265K | $485K |
| 65 | M W Buddy Smith Foundation INC | Philanthropy, Voluntarism & Grantmaking | $263K | $1.1M |
| 66 | The Grace Center of Southern Oklahoma INC | Human Services | $263K | $879K |
| 67 | Agape Ardmore INC | Housing & Shelter | $257K | $53K |
| 68 | Independent Finance Institute INC | Unclassified | $256K | $494K |
| 69 | Hickory Creek Child Center INC | Education | $246K | $478K |
| 70 | Habitat for Humanity International INC | Housing & Shelter | $246K | $1.0M |
| 71 | Hillcrest Memorial Park Cemeteryinc | Mutual & Membership Benefit | $233K | $864K |
| 72 | Mercy Memorial Health Center Auxiliary | Health Care | $225K | $173K |
| 73 | South Central Arc Users Group Scaug | Unclassified | $191K | $224K |
| 74 | Southern Oklahoma Community Arts INC | Arts, Culture & Humanities | $187K | $13K |
| 75 | The Daube Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $171K | $2.8M |
| 76 | Southern Oklahoma Board of Realtors INC | Unclassified | $162K | $299K |
| 77 | Beverly Westheimer Wellnitzcharitable Foundation INC | Philanthropy, Voluntarism & Grantmaking | $150K | $1.2M |
| 78 | Ardmore Family Literacy INC | Human Services | $149K | $13K |
| 79 | Plainview of Ardmore Public School Foundation INC | Unclassified | $148K | $686K |
| 80 | Dornick Hills Historical Foundation | Recreation & Sports | $147K | $7K |
| 81 | 20TH District Drug Court INC | Youth Development | $139K | $114K |
| 82 | Joyce House LLC | Human Services | $135K | $26K |
| 83 | Girls on the Run of Southern Oklahoma INC | Youth Development | $125K | $109K |
| 84 | Lake Ardmore Club Assn. | Unclassified | $121K | $360K |
| 85 | Kippers Gymnastics INC | Unclassified | $121K | $250K |
| 86 | Southern Oklahoma Adolescent Resources INC | Human Services | $112K | $172K |
| 87 | Ardmore Soup Kitchen INC | Food, Agriculture & Nutrition | $109K | $375K |
| 88 | Clarion Broadcasting Group INC | Religion-Related | $104K | $77K |
| 89 | East Ardmore Revitalization INC | Community Improvement & Capacity Building | $104K | $16K |
| 90 | Food for Pets | Animal-Related | $99K | $3K |
| 91 | Oklahoma State Hospice Association INC | Education | $95K | $118K |
| 92 | Take Two Alternative Educational Services of Southern Oklahoma INC | Education | $87K | $126K |
| 93 | William C Chapman Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $87K | $382K |
| 94 | Oklahoma Farm Bureau | Unclassified | $84K | $244K |
| 95 | Gideon Rescue Company | Public Safety, Disaster Preparedness & Relief | $82K | $48K |
| 96 | Keys Enabling Your Success INC | Housing & Shelter | $79K | $184K |
| 97 | Preterist Research Instituteincorporated | Religion-Related | $73K | $97K |
| 98 | Waters Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $73K | $4K |
| 99 | Strength in Numbers Foundation | Youth Development | $71K | $27K |
| 100 | Dunbar Heritage Apartments INC | Housing & Shelter | $64K | $608K |