| 1 | Syracuse University | Education | $2.4B | $4.7B |
| 2 | Crouse Health Hospital INC | Health Care | $586.6M | $340.9M |
| 3 | Visiting Nurse Association of Central New York INC | Health Care | $298.9M | $98.2M |
| 4 | New York State Teamsters Council Health & Hospital Fund | Mutual & Membership Benefit | $270.0M | $854.7M |
| 5 | Le Moyne College | Education | $180.5M | $434.9M |
| 6 | Helio Health INC | Mental Health & Crisis Intervention | $108.9M | $102.0M |
| 7 | Liberty Resources INC | Unclassified | $92.8M | $42.8M |
| 8 | Catholic Charities of the Roman Catholic Diocese of Syracuse Ny | Human Services | $79.3M | $73.6M |
| 9 | Loretto Health and Rehabilitation Center | Health Care | $73.7M | $31.0M |
| 10 | Service Employees Benefit Fund | Mutual & Membership Benefit | $70.6M | $52.1M |
| 11 | Upstate New York Engineers Health Fund | Unclassified | $63.5M | $136.6M |
| 12 | Central New York Community Foundation INC | Philanthropy, Voluntarism & Grantmaking | $61.8M | $458.3M |
| 13 | Accesscny INC | Diseases, Disorders & Medical Disciplines | $60.1M | $33.6M |
| 14 | Crouse Medical Practice Pllc | Health Care | $58.0M | $18.1M |
| 15 | Science Academies of New York Charter Schools | Unclassified | $52.9M | $71.2M |
| 16 | International Brotherhood of Electl Wkrs 43 & Electrical Contract Wlfr | Unclassified | $50.3M | $67.2M |
| 17 | Food Bank of Central New York | Food, Agriculture & Nutrition | $47.2M | $29.1M |
| 18 | Plumbers & Steamfitters Local 81 | Unclassified | $39.2M | $48.9M |
| 19 | Home Headquarters INC | Housing & Shelter | $38.2M | $128.6M |
| 20 | The Upstate Foundation INC | Human Services | $37.5M | $299.8M |
| 21 | St. Camillus Residential Health Care Facility | Unclassified | $36.9M | $22.8M |
| 22 | Upstate Community Medical P C | Health Care | $36.1M | $8.8M |
| 23 | Elmcrest Childrens Center INC | Human Services | $34.6M | $38.9M |
| 24 | Nysarc INC | Human Services | $33.8M | $20.0M |
| 25 | Housing Visions Unlimited INC | Unclassified | $33.7M | $68.9M |
| 26 | Rescue Mission Alliance of Syracuse N Y | Human Services | $33.6M | $51.7M |
| 27 | Near East Foundation | International, Foreign Affairs & National Security | $31.7M | $29.8M |
| 28 | Centerstate Corporation for Economic Opportunity | Community Improvement & Capacity Building | $31.5M | $41.6M |
| 29 | Nysernetorg INC | Education | $30.9M | $25.5M |
| 30 | Exceptional Family Resources INC | Health Care | $29.8M | $15.2M |
| 31 | Loretto Management Corporation | Health Care | $28.3M | $23.1M |
| 32 | Nysernet Net INC | Education | $27.6M | $18.6M |
| 33 | Young Mens Christian Association of Central New York INC | Human Services | $27.2M | $45.1M |
| 34 | Syracuse Community Health Center INC | Unclassified | $26.1M | $38.6M |
| 35 | Peoples Equal Action and Community Effort INC | Human Services | $25.2M | $10.5M |
| 36 | Syracuse Health Science Center Medical Alumni Foundation INC | Unclassified | $22.5M | $70.5M |
| 37 | Francis House INC | Human Services | $22.0M | $66.4M |
| 38 | Girl Scouts of Nypenn Pathways INC | Unclassified | $19.1M | $12.4M |
| 39 | Jewish Home of Central New York INC | Unclassified | $18.9M | $16.6M |
| 40 | Onondaga County Bar Association Assigned Counsel Program INC | Crime & Legal-Related | $18.8M | $3.6M |
| 41 | Center for Community Alternatives | Unclassified | $18.7M | $14.6M |
| 42 | New York State Teamsters Council - Ups Retiree Health Fund | Mutual & Membership Benefit | $17.7M | $26.1M |
| 43 | Nottingham Retirement Community INC | Housing & Shelter | $16.8M | $36.8M |
| 44 | Loretto Adult Community INC | Human Services | $16.2M | $11.3M |
| 45 | Finger Lakes Ipa INC | Unclassified | $14.6M | $20.8M |
| 46 | United Way of Central New York INC | Philanthropy, Voluntarism & Grantmaking | $14.0M | $10.1M |
| 47 | Interfaith Works of Central New York INC | Unclassified | $13.7M | $10.3M |
| 48 | Esf College Foundation INC | Education | $13.3M | $68.8M |
| 49 | Healtheconnections INC | Public & Societal Benefit | $13.1M | $21.2M |
| 50 | Manlius Pebble Hill School | Education | $13.0M | $24.4M |
| 51 | Proliteracy Worldwide | Education | $12.8M | $20.8M |
| 52 | Southside Charter School | Education | $12.4M | $1.1M |
| 53 | Toomey Residential and Community Services Corp. | Human Services | $12.1M | $7.9M |
| 54 | Frank H Hiscock Legal Aid Society | Crime & Legal-Related | $11.4M | $5.8M |
| 55 | Woodlawn Cemetery | Unclassified | $11.0M | $38.7M |
| 56 | Aids Community Resources | Education | $10.7M | $5.7M |
| 57 | Arise Child and Family Service INC | Civil Rights, Social Action & Advocacy | $10.6M | $9.0M |
| 58 | St. Josephs Health Center Properties INC | Health Care | $9.3M | $43.3M |
| 59 | Reading League | Education | $9.2M | $11.8M |
| 60 | Legal Services of Central New York INC | Crime & Legal-Related | $8.4M | $7.7M |
| 61 | Nottingham Residential Health Care Facility | Human Services | $7.9M | $8.7M |
| 62 | Public Broadcasting Council of Central New York INC Old Liverpool | Arts, Culture & Humanities | $7.7M | $16.0M |
| 63 | William G Pomeroy Foundation | Philanthropy, Voluntarism & Grantmaking | $7.3M | $114.9M |
| 64 | S U Theatre Corporation | Arts, Culture & Humanities | $7.3M | $6.7M |
| 65 | Abby Lane Housing Corporation | Education | $6.9M | $31.8M |
| 66 | Child Care Solutions INC | Unclassified | $6.8M | $8.2M |
| 67 | Cny Works INC | Unclassified | $6.7M | $3.5M |
| 68 | Crouse Health Foundation INC | Health Care | $6.5M | $32.5M |
| 69 | Service Employees International Union | Unclassified | $6.4M | $2.4M |
| 70 | International Brotherhood of Electrical Workers | Unclassified | $6.3M | $9.4M |
| 71 | Ophthalmology Medical Service Group INC | Health Care | $6.1M | $4.0M |
| 72 | Onondaga Community College Housing Development Corp. | Education | $5.8M | $33.6M |
| 73 | Friends of the Rosamond Gifford Zoo at Burnet Park INC | Animal-Related | $5.8M | $8.3M |
| 74 | Christopher Community INC | Housing & Shelter | $5.7M | $12.7M |
| 75 | Bellevue Country Club INC | Unclassified | $5.5M | $7.0M |
| 76 | Churchill Manor INC | Housing & Shelter | $5.3M | $1.7M |
| 77 | Onondaga Case Management Services INC | Human Services | $5.2M | $6.2M |
| 78 | Jowonio School | Unclassified | $5.1M | $4.5M |
| 79 | Jewish Community Center of Syracuse INC | Human Services | $5.1M | $7.8M |
| 80 | Everson Museum of Art of Syracuse and Onondaga County | Arts, Culture & Humanities | $5.0M | $27.4M |
| 81 | Centralcast LLC | Public & Societal Benefit | $4.9M | $14.6M |
| 82 | Joy of Giving Something INC | Arts, Culture & Humanities | $4.8M | $39.6M |
| 83 | Central New York Ronald McDonald House Charities INC | Unclassified | $4.8M | $14.9M |
| 84 | Volunteer Lawyers Project of Cny INC | Crime & Legal-Related | $4.6M | $2.7M |
| 85 | Syracuse Area Landmark Theatre | Arts, Culture & Humanities | $4.5M | $21.5M |
| 86 | Ua Local Union No 81 | Employment | $4.5M | $2.6M |
| 87 | Upstate Properties Development INC | Education | $4.4M | $37.9M |
| 88 | Ontech Charter High School | Education | $4.4M | $6.0M |
| 89 | Home Aides of Central New York INC | Human Services | $4.4M | $966K |
| 90 | Refugee & Immigrant Self-empowerment INC | International, Foreign Affairs & National Security | $4.4M | $2.2M |
| 91 | Onondaga Community College Foundation INC | Education | $4.3M | $30.8M |
| 92 | Iron Workers Local Union No 60 Supl Benefit Pl and Tr Wel Fd | Unclassified | $4.2M | $17.2M |
| 93 | Josephs House for Women INC | Housing & Shelter | $3.9M | $4.9M |
| 94 | North Area Volunteer Ambulance Corps INC | Health Care | $3.8M | $2.9M |
| 95 | Good Life Foundation INC | Education | $3.8M | $994K |
| 96 | Visit Syracuse INC | Community Improvement & Capacity Building | $3.8M | $1.2M |
| 97 | Faculty Student Assocn of State Univ of Ny at Syracuse Et Al | Unclassified | $3.6M | $3.4M |
| 98 | On Point for College INC | Education | $3.6M | $1.9M |
| 99 | Discovery Center of Science and Technology | Arts, Culture & Humanities | $3.6M | $8.5M |
| 100 | Cny Arts INC | Arts, Culture & Humanities | $3.5M | $2.1M |