| 1 | Healthelink INC | Health Care | $14.4M | $13.8M |
| 2 | Lord of Life Adult & Child Services INC | Human Services | $1.9M | $349K |
| 3 | Fraternal Order of Eagles | Unclassified | $1.9M | $1.3M |
| 4 | Depew-lancaster Boys & Girls Club | Unclassified | $1.0M | $2.9M |
| 5 | Knights Templar of the United States of America | Unclassified | $938K | $774K |
| 6 | Carol J Adragna Family Foundation | Philanthropy, Voluntarism & Grantmaking | $719K | $8.2M |
| 7 | People Against Trafficking Humans INC | Human Services | $461K | $1.1M |
| 8 | Friends of Reinstein Nature Preserve INC | Environment | $306K | $719K |
| 9 | Danceability Incorporated | Arts, Culture & Humanities | $294K | $180K |
| 10 | Depew Volunteer Fire Department INC | Public Safety, Disaster Preparedness & Relief | $222K | $286K |
| 11 | Hunt Charitable Foundation INC | Philanthropy, Voluntarism & Grantmaking | $198K | $183K |
| 12 | Depew Community Action Team | Community Improvement & Capacity Building | $197K | $449K |
| 13 | American Federation of Teachers | Unclassified | $178K | $127K |
| 14 | Depew Rod & Gun Club INC | Unclassified | $126K | $93K |
| 15 | Depew Police Benevolent Association INC | Employment | $90K | $320K |
| 16 | Creative Restorations INC | Crime & Legal-Related | $73K | $22K |
| 17 | Western New York Association of Retired Law Enfrcmnt Personnel INC | Crime & Legal-Related | $66K | $131K |
| 18 | Hy-view Fire Company INC | Unclassified | $59K | $173K |
| 19 | Communication Workers of America | Unclassified | $57K | $50K |
| 20 | Turiya INC | Youth Development | $54K | $34K |
| 21 | United Steelworkers | Unclassified | $53K | $46K |
| 22 | Dentico Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $40K | $3K |
| 23 | American Legion | Public & Societal Benefit | $10K | $26K |
| 24 | Kuzniarek Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $6K | $902 |
| 25 | Hunt Gallery Artists and Residents | Arts, Culture & Humanities | $6K | $298 |
| 26 | New York State Future Business Leaders of America Foundation INC | Youth Development | $3K | $33K |
| 27 | Soldiers to Statesmen | Public & Societal Benefit | $1 | $1 |
| 28 | Centerpointe Community Church INC | Religion-Related | $0 | $0 |
| 29 | American Federation of Teachers | Unclassified | $0 | $0 |
| 30 | Bidwell Family Association INC | Unclassified | $0 | $0 |
| 31 | Amvets | Unclassified | $0 | $0 |
| 32 | Twin Village Veterans Association | Unclassified | $0 | $0 |
| 33 | Blessed Mother Teresa of Calcutta | Unclassified | $0 | $0 |
| 34 | St. Barnabas R C Church | Unclassified | $0 | $0 |
| 35 | Veterans Park Baptist Church | Unclassified | $0 | $0 |
| 36 | Cantalician Center for Learning | Unclassified | $0 | $0 |
| 37 | Chapel of Gods Light INC | Unclassified | $0 | $0 |
| 38 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 39 | New York Pork Producers Co-op INC | Unclassified | $0 | $0 |
| 40 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 41 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 42 | Professional & Businessmens Association INC | Community Improvement & Capacity Building | $0 | $0 |
| 43 | Saint Johns Lutheran | Unclassified | $0 | $0 |
| 44 | Buffalo Schwaben Chor | Unclassified | $0 | $0 |
| 45 | St. Martha Roman Catholic Parish of Depew N Y | Unclassified | $0 | $0 |
| 46 | Communication Workers of America | Employment | $0 | $0 |
| 47 | Rescue Volunteer Hose Company No 1 of Cheektowaga Ny | Public Safety, Disaster Preparedness & Relief | $0 | $0 |
| 48 | The Vine Wesleyan Church | Unclassified | $0 | $0 |
| 49 | Amvets | Unclassified | $0 | $0 |
| 50 | Fraternal Order of Eagles | Unclassified | $0 | $0 |
| 51 | Retired Enlisted Association | Unclassified | $0 | $0 |
| 52 | Greyhound Action League of Buffalo | Animal-Related | $0 | $0 |
| 53 | Touching Bases Softball League of Erie County INC | Human Services | $0 | $0 |
| 54 | Resurrection Power Ministries | Youth Development | $0 | $0 |
| 55 | Nickel City Pinball Club | Recreation & Sports | $0 | $0 |
| 56 | American Muslim Affairs Coalition INC | Religion-Related | $0 | $0 |
| 57 | National Literacy Coalition | Education | $0 | $0 |
| 58 | Buffalo Joe Childrens Foundation INC | Human Services | $0 | $0 |
| 59 | Hillview Counseling Collective INC | Mental Health & Crisis Intervention | $0 | $0 |
| 60 | Delta Zeta Sorority | Unclassified | $0 | $0 |
| 61 | Little Match Girl Foundation Limited | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 62 | Depew High School Academy of Finance | Education | $0 | $0 |
| 63 | John a Sciole Elementary Parent Teacher Organization | Education | $0 | $0 |
| 64 | Our Love Saves Their Lives | Human Services | $0 | $0 |
| 65 | Maranatha Bible Fellowship INC | Unclassified | $0 | $0 |
| 66 | Mark a Monaco Memorial Foundation INC | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 67 | Tri-community Food Pantry INC | Food, Agriculture & Nutrition | $0 | $0 |
| 68 | Cat Haven of W N Y INC | Animal-Related | $0 | $0 |
| 69 | T S and D Good Agency | Health Care | $0 | $0 |
| 70 | Home City Wesleyan Church | Unclassified | $0 | $0 |
| 71 | Cancer Cant Kill Hope INC | Human Services | $0 | $0 |
| 72 | Positive Youth of Tommorrow | Youth Development | $0 | $0 |
| 73 | Brian S Strobele Memorial Foundation INC | Crime & Legal-Related | $0 | $0 |
| 74 | Wny Food 4 Paws INC | Animal-Related | $0 | $0 |
| 75 | South Yemen Charity Community Center INC | Community Improvement & Capacity Building | $0 | $0 |
| 76 | Parent Booster USA INC | Education | $0 | $0 |
| 77 | Parent Booster USA INC | Unclassified | $0 | $0 |
| 78 | Gary Powers Foundation INC | Arts, Culture & Humanities | $0 | $0 |
| 79 | Upstate New York Black and Latino Pride | Human Services | $0 | $0 |
| 80 | Bill & Toni Clark Ministries INC | Religion-Related | $0 | $0 |
| 81 | Wesleyan Church Corp. | Unclassified | $0 | $0 |