| 1 | Daemen University | Education | $146.3M | $86.7M |
| 2 | Academic Medicine Services INC | Health Care | $49.8M | $18.6M |
| 3 | Energy Cooperative of America INC | Mutual & Membership Benefit | $38.4M | $10.4M |
| 4 | Frontier Science and Technology Research Foundation INC | Diseases, Disorders & Medical Disciplines | $31.0M | $18.0M |
| 5 | Hearing Evaluation Services of Buffalo INC | Health Care | $8.2M | $2.7M |
| 6 | Center for Inquiry INC | Arts, Culture & Humanities | $7.3M | $6.7M |
| 7 | Center for Handicapped Children INC | Education | $4.8M | $2.9M |
| 8 | Better Business Bureau INC | Unclassified | $4.7M | $5.4M |
| 9 | Dent Neurosciences Research Center INC | Medical Research | $4.3M | $5.6M |
| 10 | Buffalo Niagara Association of Realtors INC | Community Improvement & Capacity Building | $3.5M | $4.0M |
| 11 | Communication Workers of America | Unclassified | $3.1M | $4.2M |
| 12 | Center for Inquiry Development Fund | Philanthropy, Voluntarism & Grantmaking | $1.8M | $34.9M |
| 13 | North Bailey Fire Company INC | Public Safety, Disaster Preparedness & Relief | $1.5M | $2.1M |
| 14 | New York State Amateur Hockey Association INC | Unclassified | $1.4M | $880K |
| 15 | Bison Hockey Association INC | Recreation & Sports | $1.1M | $167K |
| 16 | Printing and Imaging Association of New York State INC | Unclassified | $1.1M | $1.8M |
| 17 | National Coalition for Assistive and Rehab Technology | Community Improvement & Capacity Building | $988K | $51K |
| 18 | Buddys Second Chance Rescue INC | Human Services | $942K | $1.2M |
| 19 | Ellicott Creek Volunteer Fire Company INC | Unclassified | $898K | $3.6M |
| 20 | Junior Achievement of Western New York | International, Foreign Affairs & National Security | $809K | $787K |
| 21 | Life Sounds Audiology INC | Human Services | $696K | $438K |
| 22 | Jewish Heritage Day School of Buffalo | Education | $690K | $1.6M |
| 23 | Buffalo Niagara Heritage Village | Arts, Culture & Humanities | $598K | $513K |
| 24 | Shaarey Zedek Housing Development Fund Corporation | Housing & Shelter | $531K | $2.6M |
| 25 | Hillel the Foundation for Jewish Campus Life | Unclassified | $505K | $390K |
| 26 | Bruce T Williams Family Foundation | Philanthropy, Voluntarism & Grantmaking | $465K | $1.4M |
| 27 | Buffalo Underdogs Rescue INC | Animal-Related | $434K | $7K |
| 28 | Buffalo Sabres Alumni Association | Philanthropy, Voluntarism & Grantmaking | $395K | $611K |
| 29 | Audubon Association INC | Unclassified | $375K | $911K |
| 30 | Amherst Nursery School INC | Education | $343K | $156K |
| 31 | 716 Promoting Animal Welfare & Safety INC | Animal-Related | $334K | $102K |
| 32 | Amherst Senior Transportation Services INC | Unclassified | $332K | $406K |
| 33 | American Federation of Teachers | Unclassified | $320K | $65K |
| 34 | Snyder Volunteer Firefighters Benevolent Assn. | Public Safety, Disaster Preparedness & Relief | $268K | $651K |
| 35 | Anna Verna Howe Tr Uw | Unclassified | $265K | $849K |
| 36 | North Amherst Fire Company | Public Safety, Disaster Preparedness & Relief | $243K | $669K |
| 37 | The National Federation for Just Communities of Western New York | Civil Rights, Social Action & Advocacy | $209K | $151K |
| 38 | Starring Buffalo INC | Arts, Culture & Humanities | $206K | $40K |
| 39 | Regional Affiliate Certificate Group INC | Community Improvement & Capacity Building | $166K | $120K |
| 40 | Civil Service Employees Association | Unclassified | $153K | $202K |
| 41 | Messianic Times INC | Religion-Related | $145K | $1.3M |
| 42 | Amherst Police Foundation INC | Crime & Legal-Related | $142K | $111K |
| 43 | Professional Animal Care Certification Council | Community Improvement & Capacity Building | $128K | $127K |
| 44 | Friends of Buffalo Creek INC | Education | $117K | $50K |
| 45 | Demakos Foundation INC | Unclassified | $113K | $129K |
| 46 | Free & Accepted Masons of New York | Unclassified | $102K | $502K |
| 47 | Jack and Elizabeth Gellman Torah Foundation INC | Religion-Related | $101K | $6.9M |
| 48 | Lutheran Association for Developementally Disabled INC | Human Services | $100K | $573K |
| 49 | Empire State Association of the Deaf | Unclassified | $95K | $538K |
| 50 | Amherst Senior Citizen Foundation INC | Unclassified | $94K | $216K |
| 51 | Skating Club of Western New York | Recreation & Sports | $85K | $171K |
| 52 | Jordan Nwora Foundation | Youth Development | $80K | $18K |
| 53 | New York State Parking and Transportation Association | Unclassified | $78K | $23K |
| 54 | Amherst Community Foundation | Philanthropy, Voluntarism & Grantmaking | $76K | $196K |
| 55 | International Academy of Minidental Implants | Health Care | $74K | $26K |
| 56 | Williamsville Stampede INC | Youth Development | $72K | $75K |
| 57 | Amherst Central Schools Foundation INC | Unclassified | $65K | $1.2M |
| 58 | Western New York Safety Conference INC | Health Care | $65K | $42K |
| 59 | Lutheran Service Society Foundation | Unclassified | $58K | $1.3M |
| 60 | Jessas Quest INC | Medical Research | $55K | $25K |
| 61 | The Childrens Growth Foundation | Unclassified | $55K | $31K |
| 62 | Oconnell & Company Productions INC | Arts, Culture & Humanities | $55K | $12K |
| 63 | Harold J & Arlyne G Levy Fam Foundation | Unclassified | $49K | $77K |
| 64 | Cf Foundation | Unclassified | $35K | $200K |
| 65 | Free and Accepted Masons of New York | Unclassified | $24K | $122K |
| 66 | Edward Doc Butler Family Foundation | Philanthropy, Voluntarism & Grantmaking | $23K | $687K |
| 67 | Bingel Family Foundation | Philanthropy, Voluntarism & Grantmaking | $21K | $238K |
| 68 | Foundation for the Right of Developmentally Disabled Adults in | Mental Health & Crisis Intervention | $20K | $2K |
| 69 | Calamar Foundation INC | Philanthropy, Voluntarism & Grantmaking | $13K | $24K |
| 70 | Heel to Heal Sole to Soul H2s2 Foundation | Public & Societal Benefit | $5K | $7K |
| 71 | Town of Amherst Development Corporation | Community Improvement & Capacity Building | $4K | $24K |
| 72 | Pia Nys Graphic Arts Education Foundation INC | Unclassified | $3K | $20K |
| 73 | Wild Spirit Education | Mental Health & Crisis Intervention | $2K | $11K |
| 74 | Afghan Community INC | Arts, Culture & Humanities | $1 | $3K |
| 75 | Toc for Education | Education | $0 | $0 |
| 76 | State University of New York Financial Aid Professionals INC | Community Improvement & Capacity Building | $0 | $0 |
| 77 | Psi Chi the National Honor Society in Psychology | Unclassified | $0 | $0 |
| 78 | Foundation for Orthopaedic Research Continuing Education INC | Education | $0 | $0 |
| 79 | Creekside Assembly of God | Unclassified | $0 | $0 |
| 80 | Grace and Truth Church | Religion-Related | $0 | $0 |
| 81 | Lowdale Preserve INC | Recreation & Sports | $0 | $0 |
| 82 | Engineering Society of Buffalo INC | Unclassified | $0 | $0 |
| 83 | Christ King R C Church Society INC | Unclassified | $0 | $0 |
| 84 | Boulevard Federal Credit Union | Unclassified | $0 | $0 |
| 85 | Buffalo and Erie County Public Library Co | Unclassified | $0 | $0 |
| 86 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $0 | $0 |
| 87 | Western New York Jamaica Partners of the Americas INC | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 88 | Association of Notre Dame Clubs INC | Unclassified | $0 | $0 |
| 89 | Amherst Museum Foundation INC | Unclassified | $0 | $0 |
| 90 | Animal Rights Advocates of Western New York INC | Unclassified | $0 | $0 |
| 91 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 92 | Amherst | Unclassified | $0 | $0 |
| 93 | Nine Mile Island Camp INC | Unclassified | $0 | $0 |
| 94 | Lss Properties INC | Unclassified | $0 | $162K |
| 95 | Lederhosen Ski Club INC | Recreation & Sports | $0 | $0 |
| 96 | Faith Partners Ministries | Religion-Related | $0 | $0 |
| 97 | Amherst Tigers Booster Club | Recreation & Sports | $0 | $0 |
| 98 | Diocesan Elementary Teachers Assoc Deta | Unclassified | $0 | $0 |
| 99 | Niagara Frontier City Ministries INC | Human Services | $0 | $0 |
| 100 | Professional Macintosh Users Group INC | Recreation & Sports | $0 | $0 |