| 1 | Albany Medical Center Group Organization | Unclassified | $3.4B | $2.7B |
| 2 | Research Foundation for the State University of New York | Education | $2.4B | $1.9B |
| 3 | World Federation of Hemophilia USA | Diseases, Disorders & Medical Disciplines | $1.1B | $377.6M |
| 4 | St. Peters Hospital | Health Care | $810.4M | $672.4M |
| 5 | S & G Foundation | Philanthropy, Voluntarism & Grantmaking | $774.8M | $1.8B |
| 6 | New York State Nurses Association Benefit Fund | Mutual & Membership Benefit | $584.7M | $119.9M |
| 7 | Albany Med Health System | Health Care | $317.0M | $513.8M |
| 8 | New York State Industries for the Disabled INC | Unclassified | $296.3M | $103.9M |
| 9 | St. Peters Health Partners Medical Associates Pc | Health Care | $288.3M | $96.5M |
| 10 | Weill Family Foundation | Unclassified | $256.5M | $390.2M |
| 11 | St. Peters Health Partners | Health Care | $193.0M | $141.4M |
| 12 | Care Design New York LLC | Health Care | $191.2M | $79.4M |
| 13 | Gray Foundation | Philanthropy, Voluntarism & Grantmaking | $137.8M | $83.4M |
| 14 | Center for Disability Services INC | Diseases, Disorders & Medical Disciplines | $125.8M | $96.1M |
| 15 | Research Foundation Post Retirement Benefits Plan | Mutual & Membership Benefit | $122.6M | $328.8M |
| 16 | Fuller Road Management Corporation | Unclassified | $110.9M | $528.8M |
| 17 | New York Ehealth Collaborative INC | Health Care | $93.4M | $88.2M |
| 18 | Consumer Directed Choices | Human Services | $90.6M | $33.7M |
| 19 | Excelsior University | Education | $83.3M | $74.7M |
| 20 | Albany College of Pharmacy and Health Sciences | Education | $78.9M | $140.2M |
| 21 | New York State Nurses Association | Unclassified | $65.4M | $126.6M |
| 22 | Iag Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $64.0M | $102.1M |
| 23 | Albany Law School | Education | $60.5M | $107.5M |
| 24 | Parsons Child & Family Center | Human Services | $60.3M | $51.5M |
| 25 | Public Employees Federation Membership Benefits Program | Unclassified | $60.3M | $26.9M |
| 26 | Living Resources Corp. | Human Services | $56.2M | $32.7M |
| 27 | Service Employees International Union | Unclassified | $51.2M | $39.2M |
| 28 | University at Albany Foundation | Education | $50.5M | $238.7M |
| 29 | Young Mens Christian Association of the Capital District | Human Services | $50.3M | $54.5M |
| 30 | United University Professions Benefit Trust Fund | Unclassified | $50.1M | $117.4M |
| 31 | Catholic Charities of Diocese of Albany | Unclassified | $49.3M | $35.9M |
| 32 | Kipp Tech Valley Charter School | Education | $47.4M | $103.6M |
| 33 | Richard & Mary Templeton Foundation | Philanthropy, Voluntarism & Grantmaking | $46.8M | $109.3M |
| 34 | Ny Creates | Science & Technology | $43.1M | $49.1M |
| 35 | The Community Hospice INC | Human Services | $43.1M | $81.2M |
| 36 | Northeast Parent and Child Society INC | Human Services | $40.9M | $31.4M |
| 37 | Abrahams Blessing | International, Foreign Affairs & National Security | $39.4M | $14.4M |
| 38 | College of Saint Rose | Education | $38.7M | $27.5M |
| 39 | Teresian House Nursing Home Co INC | Health Care | $38.2M | $25.5M |
| 40 | Center for Disability Service Holding Corporation | Human Services | $37.9M | $16.2M |
| 41 | Firemens Association of the State New York Foundation INC | Education | $37.1M | $161.0M |
| 42 | New York State Bar Association | Unclassified | $33.7M | $76.4M |
| 43 | Danoff Fam Private Charitable Foundation Tr | Philanthropy, Voluntarism & Grantmaking | $33.6M | $144.8M |
| 44 | Whitney M Young Jr Health Center INC | Health Care | $32.2M | $54.8M |
| 45 | Knickerbocker 4TH & Madison LLC | Community Improvement & Capacity Building | $32.2M | $202.3M |
| 46 | Firemens Association of the State of New York | Housing & Shelter | $31.1M | $54.6M |
| 47 | Lindmor Foundation INC | Philanthropy, Voluntarism & Grantmaking | $29.2M | $49.2M |
| 48 | Daughters of Sarah Nursing Center INC | Health Care | $29.2M | $48.2M |
| 49 | Albany Academy | Unclassified | $28.8M | $56.0M |
| 50 | Candace King Weir Foundation | Unclassified | $28.2M | $68.0M |
| 51 | The Community Foundation for the Greater Capital Region INC | Philanthropy, Voluntarism & Grantmaking | $27.1M | $119.8M |
| 52 | Nuttall Philanthropies INC | Philanthropy, Voluntarism & Grantmaking | $26.1M | $78.1M |
| 53 | New York Association on Independent Living | Human Services | $23.8M | $12.5M |
| 54 | Massry Charitable Foundation INC | Philanthropy, Voluntarism & Grantmaking | $22.8M | $48.7M |
| 55 | St. Catherines Center for Children | Unclassified | $22.5M | $13.1M |
| 56 | Four Friends Foundation | Unclassified | $21.7M | $35.9M |
| 57 | Henry & Elaine Kaufman Foundation INC | Unclassified | $20.7M | $18.4M |
| 58 | Kaye Family Foundation | Philanthropy, Voluntarism & Grantmaking | $18.7M | $10.0M |
| 59 | New York State Correctional | Employment | $18.3M | $33.0M |
| 60 | Natural Heritage Trust | Unclassified | $17.9M | $66.2M |
| 61 | Maria College | Unclassified | $17.8M | $27.2M |
| 62 | Empire Commons Student Housing INC | Education | $17.4M | $53.4M |
| 63 | Legal Aid Society of Northeastern New York INC | Crime & Legal-Related | $17.0M | $11.9M |
| 64 | Workforce Development Institute INC | Education | $16.4M | $4.4M |
| 65 | Turtle Pond Foundation | Philanthropy, Voluntarism & Grantmaking | $16.3M | $17.4M |
| 66 | La Salle School INC | Education | $15.7M | $19.8M |
| 67 | Titus Adams Foundation | Philanthropy, Voluntarism & Grantmaking | $15.2M | $9.5M |
| 68 | Villa Mary Immaculate | Health Care | $15.1M | $13.8M |
| 69 | Tillerson Foundation | Philanthropy, Voluntarism & Grantmaking | $15.0M | $19.5M |
| 70 | Capitalize Albany Corporation | Community Improvement & Capacity Building | $14.8M | $25.0M |
| 71 | Saint Anne Institute | Unclassified | $14.7M | $7.8M |
| 72 | University Auxiliary Services at Albany INC | Education | $14.4M | $32.9M |
| 73 | Peter a and Deborah L Weinberg Family Foundation | Philanthropy, Voluntarism & Grantmaking | $14.0M | $10.0M |
| 74 | Healthcare Information Xchange of New York INC | Health Care | $13.7M | $14.8M |
| 75 | Carl E Touhey Foundation | Unclassified | $13.2M | $37.2M |
| 76 | The Addictions Care Center of Albany INC | Mental Health & Crisis Intervention | $13.0M | $18.5M |
| 77 | Hope House INC | Mental Health & Crisis Intervention | $12.9M | $15.6M |
| 78 | Northeastern Association of the Blind at Albany INC | Unclassified | $12.8M | $5.8M |
| 79 | Special Olympics New York INC | Unclassified | $12.8M | $8.8M |
| 80 | Albany County Opportunity Incorporated | Human Services | $12.6M | $11.1M |
| 81 | Hunger Solutions New York INC | Food, Agriculture & Nutrition | $12.1M | $13.5M |
| 82 | Albany Guardian Society | Unclassified | $12.0M | $17.3M |
| 83 | Brighter Choice Elementary Charter Schools | Education | $11.7M | $23.1M |
| 84 | Police Benevolent Association New York State Troopers INC | Unclassified | $11.6M | $36.1M |
| 85 | Bricklayers & Allied Craftworkers Loc 2 Albany Ny Health Ben Fund | Unclassified | $11.5M | $13.0M |
| 86 | Equinox INC | Housing & Shelter | $11.5M | $8.9M |
| 87 | Aids Council of Northeastern New York INC | Diseases, Disorders & Medical Disciplines | $11.3M | $6.1M |
| 88 | Northern Rivers Family Services INC | Human Services | $11.2M | $4.2M |
| 89 | The David a Coulter and Susan C Weeks Charitable Foundation | Community Improvement & Capacity Building | $11.1M | $5.4M |
| 90 | Welfare Research INC | Unclassified | $10.9M | $3.5M |
| 91 | Albany Med Health System | Health Care | $10.8M | $4.2M |
| 92 | Sidney J Weinberg Foundation | Unclassified | $10.7M | $21.1M |
| 93 | Interfaith Partnership for the Homeless | Housing & Shelter | $10.1M | $18.6M |
| 94 | Fort Schuyler Management Corporation | Education | $9.9M | $101.3M |
| 95 | Upper Hudson Planned Parenthood INC | Health Care | $9.8M | $10.6M |
| 96 | Callahan Dee Family Foundation | Philanthropy, Voluntarism & Grantmaking | $9.5M | $13.0M |
| 97 | International Brotherhood of Teamsters | Employment | $9.5M | $5.7M |
| 98 | Teresian House Housing Corporation | Housing & Shelter | $9.5M | $30.9M |
| 99 | New York State Association of Realtors | Unclassified | $9.4M | $26.9M |
| 100 | Wilson Garling Foundation Nfp | Philanthropy, Voluntarism & Grantmaking | $9.3M | $20.4M |