| 1 | North Mississippi Medical Center INC | Health Care | $2.0B | $1.6B |
| 2 | Tombigbee Electric Power Assn. | Unclassified | $136.4M | $266.0M |
| 3 | Clay County Medical Corporation | Health Care | $66.1M | $51.5M |
| 4 | Monroe Health Services INC | Health Care | $63.4M | $52.0M |
| 5 | North Mississippi Health Services INC | Health Care | $61.0M | $129.8M |
| 6 | North Mississippi Medical Clinics | Health Care | $56.0M | $253.4M |
| 7 | Pontotoc Health Services INC | Health Care | $33.2M | $37.4M |
| 8 | Global Outreach International INC | International, Foreign Affairs & National Security | $27.2M | $18.5M |
| 9 | Create Foundation INC | Philanthropy, Voluntarism & Grantmaking | $26.7M | $181.6M |
| 10 | Webster Health Services INC | Health Care | $25.6M | $34.5M |
| 11 | United Methodist Senior Services Health Care INC | Health Care | $19.3M | $6.7M |
| 12 | Tishomingo Health Services INC | Health Care | $18.9M | $9.7M |
| 13 | Marion Regional Medical Center INC | Health Care | $18.7M | $7.6M |
| 14 | Mississippi Methodist Senior Services INC | Human Services | $16.9M | $22.6M |
| 15 | Brevard Family Foundation | Philanthropy, Voluntarism & Grantmaking | $10.8M | $21.3M |
| 16 | United Methodist Senior Services of Golden Triangle Area INC | Health Care | $9.7M | $5.3M |
| 17 | Eight Days of Hope INC | Housing & Shelter | $9.0M | $13.1M |
| 18 | Martha Coker Home INC | Health Care | $8.0M | $4.4M |
| 19 | Dugan Memorial Home INC | Health Care | $7.3M | $3.7M |
| 20 | Cadence Bank Foundation | Philanthropy, Voluntarism & Grantmaking | $7.2M | $43.2M |
| 21 | Sanctuary Hospice House INC | Human Services | $7.2M | $7.3M |
| 22 | Tupelo Childrens Mansion Ministries INC | Unclassified | $6.4M | $15.1M |
| 23 | Oakwood Foundation Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $5.4M | $7.7M |
| 24 | Lift INC | Unclassified | $5.3M | $916K |
| 25 | Community Development Foundation | Unclassified | $5.3M | $30.7M |
| 26 | United Methodist Senior Services of Desoto County INC | Health Care | $4.7M | $5.1M |
| 27 | Health Care Foundation of North Mississippi | Health Care | $4.5M | $13.5M |
| 28 | Chickasaw Inkana Foundation | Arts, Culture & Humanities | $4.3M | $44.5M |
| 29 | United Methodist Senior Services of Jackson Area INC | Human Services | $4.3M | $4.4M |
| 30 | North Mississippi Emergency Services INC | Health Care | $4.1M | $3.4M |
| 31 | United Way of Union County INC | Philanthropy, Voluntarism & Grantmaking | $3.9M | $4.2M |
| 32 | Seashore Campgrounds Retirement Home INC | Housing & Shelter | $3.2M | $12.7M |
| 33 | United Methodist Senior Services of Tupelo Area INC | Human Services | $3.0M | $7.3M |
| 34 | Regional Rehabilitation Center INC | Unclassified | $2.9M | $7.2M |
| 35 | Powell Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.6M | $9.3M |
| 36 | Wilemon Foundation INC | Arts, Culture & Humanities | $2.6M | $7.5M |
| 37 | Afa Action INC | Civil Rights, Social Action & Advocacy | $2.5M | $413K |
| 38 | United Methodist Senior Services of Columbus Area INC | Housing & Shelter | $2.5M | $2.1M |
| 39 | United Way of Northeast Mississippi INC | Philanthropy, Voluntarism & Grantmaking | $2.4M | $3.4M |
| 40 | Aldersgate Personal Care INC | Human Services | $2.4M | $4.4M |
| 41 | Henry Mize Charitable Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.4M | $6.6M |
| 42 | Tupelo Youth Sports Council INC | Recreation & Sports | $2.3M | $544K |
| 43 | Shelter & Assistance in Family Emergencies INC | Unclassified | $2.1M | $1.4M |
| 44 | Little Angels Learning & Child Care Ctr | Human Services | $1.9M | $739K |
| 45 | Patterson Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.9M | $3.4M |
| 46 | Boys Girls Club of North Mississipp I | Youth Development | $1.8M | $4.0M |
| 47 | The Family Resource Center of North Mississippi INC | Human Services | $1.8M | $539K |
| 48 | Tupelo Lee Humane Society | Animal-Related | $1.6M | $2.4M |
| 49 | New Beginnings International Children and Family Services | Human Services | $1.6M | $1.4M |
| 50 | Habitat for Humanity International INC | Housing & Shelter | $1.4M | $4.7M |
| 51 | United Methodist Senior Services of Clarksdale Area INC | Unclassified | $1.3M | $2.6M |
| 52 | Faith Haven INC | Unclassified | $1.3M | $1.8M |
| 53 | Palmetto Water System INC | Unclassified | $1.2M | $2.9M |
| 54 | Carl and Jessie Summers Scholarship Fund | Philanthropy, Voluntarism & Grantmaking | $1.2M | $6.7M |
| 55 | Aldersgate Retirement Community INC | Unclassified | $1.2M | $1.5M |
| 56 | Neighborhood Development Corporation | Housing & Shelter | $1.2M | $1.3M |
| 57 | Kids Landing Day Care and Learning Center INC | Human Services | $1.1M | $605K |
| 58 | Lauderdale Senior Services INC | Housing & Shelter | $1.1M | $2.5M |
| 59 | Tender Care Childcare Preschool and Kindergarten | Human Services | $1.1M | $603K |
| 60 | Wesley Manor Retirement Community INC | Housing & Shelter | $1.1M | $953K |
| 61 | Parkgate Health Services INC | Civil Rights, Social Action & Advocacy | $1.0M | $2.0M |
| 62 | Austism Center of North Mississippi | Diseases, Disorders & Medical Disciplines | $981K | $437K |
| 63 | Natchez Trace Council | Unclassified | $926K | $2.0M |
| 64 | 8 Deer Trust | Philanthropy, Voluntarism & Grantmaking | $893K | $925K |
| 65 | Janice Hancock Alen Family Foundation INC | Unclassified | $822K | $3.1M |
| 66 | Hattiesburg Area Senior Services INC | Unclassified | $742K | $987K |
| 67 | Salt and Light Foundation | Philanthropy, Voluntarism & Grantmaking | $726K | $2.6M |
| 68 | Montessori School of Tupelo Mississippi INC | Education | $709K | $477K |
| 69 | Easter Seals Mississippi INC | Human Services | $582K | $356K |
| 70 | Albert W Loftin Trust | Unclassified | $571K | $1.4M |
| 71 | Frank K Spain Foundation INC | Arts, Culture & Humanities | $513K | $7.7M |
| 72 | Greene County Retirement System INC | Unclassified | $472K | $587K |
| 73 | Church After School Association INC | Unclassified | $426K | $155K |
| 74 | One Parent One Dream Foundation | Human Services | $412K | $321K |
| 75 | Good Samaritan Health Services INC | Health Care | $396K | $1.5M |
| 76 | North Ms Symphony Orchestra | Arts, Culture & Humanities | $395K | $276K |
| 77 | Northeast Mississippi Board of Realtors INC | Community Improvement & Capacity Building | $385K | $683K |
| 78 | William T Childs III Charitabletrust Uw Dated 10 28 2004 | Philanthropy, Voluntarism & Grantmaking | $362K | $1.5M |
| 79 | Farm Bureau Federation Mississippi | Unclassified | $349K | $540K |
| 80 | Junior Auxiliary of Tupelo Mississippi INC | Youth Development | $348K | $789K |
| 81 | North Mississippi Medical Center Auxiliary | Health Care | $324K | $1.3M |
| 82 | Elizabeth Entrikin Cooke Foundation | Philanthropy, Voluntarism & Grantmaking | $316K | $1.2M |
| 83 | Doyce H Deas Foundation | Education | $296K | $2.9M |
| 84 | Harrisburg Cultural and Social Services Center INC | Human Services | $282K | $1.2M |
| 85 | Charles and Annece Conlee Charitable Foundation | Education | $272K | $751K |
| 86 | Hope Family Ministries INC | Religion-Related | $258K | $192K |
| 87 | A Helping Hand for Africa INC | Religion-Related | $249K | $7K |
| 88 | Good Cause INC | Mental Health & Crisis Intervention | $241K | $145K |
| 89 | Tupelo Ballet INC | Unclassified | $239K | $138K |
| 90 | Tupelo Community Theatre INC | Arts, Culture & Humanities | $238K | $485K |
| 91 | United Methodist Senior Services of Clay County INC | Housing & Shelter | $222K | $98K |
| 92 | Sonshine Christian Camp | Religion-Related | $192K | $1.8M |
| 93 | Climb-up INC | Human Services | $191K | $478K |
| 94 | Arbol de la Vida INC | Health Care | $185K | $777K |
| 95 | The Shine Foundation | Human Services | $183K | $155K |
| 96 | Catch Kids INC | Health Care | $181K | $99K |
| 97 | St. Luke Food Pantry | Food, Agriculture & Nutrition | $178K | $162K |
| 98 | Church of the Holy Trinity Tr Ua Francis J Mee & Sue Mee Char Tr 2 | Philanthropy, Voluntarism & Grantmaking | $174K | $643K |
| 99 | Tupelo Womens Club INC | Philanthropy, Voluntarism & Grantmaking | $140K | $7K |
| 100 | Stone Stories Ministries INC | Human Services | $136K | $36K |