| 1 | Missouri Delta Medical Center | Health Care | $160.6M | $98.0M |
| 2 | Delta Area Economic Opportunity Corporation | Unclassified | $30.5M | $27.7M |
| 3 | Southeast Missouri Food Bank | Food, Agriculture & Nutrition | $26.5M | $20.8M |
| 4 | Bootheel Counseling Services | Mental Health & Crisis Intervention | $13.1M | $10.6M |
| 5 | Kenny Rogers Childrens Center | Unclassified | $9.0M | $6.4M |
| 6 | Sikeston Jaycee Bootheel Rodeo Association Incorporated | Unclassified | $2.4M | $4.2M |
| 7 | Sikeston Regional Chamber of Commerce INC | Community Improvement & Capacity Building | $2.3M | $1.5M |
| 8 | Missouri Bootheel Regional Consortium Incorporated | Health Care | $1.7M | $532K |
| 9 | Knights of Columbus | Unclassified | $1.7M | $4.2M |
| 10 | YMCA of Southeast Missouri | Human Services | $1.3M | $6.7M |
| 11 | Veterans of Foreign Wars Dept of | Unclassified | $1.3M | $331K |
| 12 | Sikeston Public Schools Foundation | Education | $1.3M | $3.2M |
| 13 | Missouri Delta Medical Center Foundation | Unclassified | $1.2M | $6.3M |
| 14 | Community Sheltered Workshop INC | Employment | $871K | $1.5M |
| 15 | American Legion Auxiliary | Unclassified | $819K | $91K |
| 16 | Fraternal Order of Eagles | Unclassified | $656K | $979K |
| 17 | Scott County Transit System INC | Unclassified | $602K | $259K |
| 18 | Benevolent and Protective Order of Elks of the USA | Mutual & Membership Benefit | $577K | $920K |
| 19 | American Legion Post 114 | Public & Societal Benefit | $554K | $417K |
| 20 | Sikeston Christian School | Education | $514K | $2.0M |
| 21 | Mission Missouri | Food, Agriculture & Nutrition | $441K | $358K |
| 22 | House of Refuge for Battered and Abused Women | Human Services | $426K | $654K |
| 23 | Sikeston Area Economic Development Corporation | Community Improvement & Capacity Building | $331K | $239K |
| 24 | American Postal Workers Union | Unclassified | $258K | $557K |
| 25 | Spread Hope Now INC | Human Services | $257K | $443K |
| 26 | Southeast Missouri Christian Academy INC | Education | $149K | $62K |
| 27 | Pregnancy Resource Center of Sikeston | Human Services | $147K | $130K |
| 28 | My Fathers House | Religion-Related | $75K | $38K |
| 29 | Epsilon Iota of Pi Kappa Alpha INC | Education | $71K | $4K |
| 30 | Historic Midtown Development Group | Community Improvement & Capacity Building | $68K | $15K |
| 31 | Sikeston Little Theatre INC | Arts, Culture & Humanities | $62K | $98K |
| 32 | Semo Electric Foundation INC | Education | $57K | $43K |
| 33 | Rotary International | Unclassified | $54K | $13K |
| 34 | International Association of Lions Clubs | Unclassified | $53K | $55K |
| 35 | Sikeston Cultural Development | Arts, Culture & Humanities | $49K | $20K |
| 36 | Highway Hero Honoree Scholarship | Unclassified | $48K | $13K |
| 37 | Sikeston Little League INC | Unclassified | $48K | $43K |
| 38 | Sikeston-bootheel Area United Way INC | Philanthropy, Voluntarism & Grantmaking | $39K | $31K |
| 39 | Robert Chase Rodgers Memorial Scholarship | Education | $1K | $100 |
| 40 | New Deliverance Outreach Ministries INC | Community Improvement & Capacity Building | $0 | $0 |
| 41 | Altrusa International Foundation INC | Education | $0 | $0 |
| 42 | Ron Shum Evangelistic Association | Religion-Related | $0 | $0 |
| 43 | VFW Auxiliary Department of Missouri | Unclassified | $0 | $0 |
| 44 | Ancient Free & Accepted Masons of Missouri | Unclassified | $0 | $0 |
| 45 | Delta Kappa Gamma Society International | Unclassified | $0 | $0 |
| 46 | Fraternal Order of Eagles | Mutual & Membership Benefit | $0 | $0 |
| 47 | Cbc Family Life Outreach Center INC | Recreation & Sports | $0 | $0 |
| 48 | New Direction Outreach Ministries | Religion-Related | $0 | $0 |
| 49 | Terra Nova | Religion-Related | $0 | $0 |
| 50 | Missouri 911 Directors Association | Community Improvement & Capacity Building | $0 | $0 |
| 51 | VFW Auxiliary Department of Missouri | Unclassified | $0 | $0 |
| 52 | Glory of God Church of God in Christ | Unclassified | $0 | $0 |
| 53 | Community Builders of Sikeston INC | Housing & Shelter | $0 | $0 |
| 54 | Day 366 | Housing & Shelter | $0 | $0 |
| 55 | I a M Research & Wellness Foundation | Arts, Culture & Humanities | $0 | $0 |
| 56 | Crossroads Hope Community Church Sikeston | Unclassified | $0 | $0 |
| 57 | Arise Ministries | Religion-Related | $0 | $0 |
| 58 | Brightlife Recovery Foundation INC | Mental Health & Crisis Intervention | $0 | $0 |
| 59 | Comfort Cause of Se Missouri | Diseases, Disorders & Medical Disciplines | $0 | $0 |
| 60 | Sunset Community Housing Partnership | Housing & Shelter | $0 | $0 |
| 61 | Scott County Backstoppers | Public Safety, Disaster Preparedness & Relief | $0 | $0 |
| 62 | Tanner St. Church of God | Unclassified | $0 | $0 |
| 63 | First Baptist Church | Unclassified | $0 | $0 |
| 64 | First Christian Church | Unclassified | $0 | $0 |
| 65 | Murray Lane Baptist Church | Unclassified | $0 | $0 |
| 66 | First Assembly of God | Unclassified | $0 | $0 |
| 67 | Concordia Lutheran Church | Unclassified | $0 | $0 |
| 68 | First United Methodist Church of Sikeston | Unclassified | $0 | $0 |
| 69 | Miner Baptist Church | Unclassified | $0 | $0 |
| 70 | North Acres Recreation Club INC | Unclassified | $0 | $0 |
| 71 | First Baptist Church of Miner Missouri | Unclassified | $0 | $0 |
| 72 | Altrusa International INC | Unclassified | $0 | $0 |
| 73 | St. Pauls Episcopal Church | Unclassified | $0 | $0 |
| 74 | Executive Board of the Missouri Baptist Convention | Unclassified | $0 | $0 |
| 75 | St. John Missionary Baptist Church | Unclassified | $0 | $0 |
| 76 | One Church Upc INC | Religion-Related | $0 | $0 |
| 77 | Farm Credit Southeast Missouri Flca | Public & Societal Benefit | $0 | $0 |
| 78 | Gospel Assembly Church | Unclassified | $0 | $0 |
| 79 | Association of Operating Room Nurses INC | Unclassified | $0 | $0 |
| 80 | Sikeston Youth Soccer League Incorporated | Youth Development | $0 | $0 |
| 81 | Total Health Environment Group INC | Unclassified | $0 | $0 |
| 82 | Greater Works Church of Jesus Christ INC | Unclassified | $0 | $0 |
| 83 | Daughters of Sunset | Human Services | $0 | $0 |
| 84 | Sikeston Bulldog Booster Club INC | Unclassified | $0 | $0 |
| 85 | Love and Lite Church Ministry INC | Unclassified | $0 | $0 |
| 86 | Bahais of Sikeston | Unclassified | $0 | $0 |
| 87 | Trinity Gospel Church | Religion-Related | $0 | $0 |
| 88 | Sikeston Economic Development Corporation | Community Improvement & Capacity Building | $0 | $1 |
| 89 | Kings Way Christian Church | Religion-Related | $0 | $0 |
| 90 | Kingdom Living Ministries INC | Human Services | $0 | $0 |
| 91 | Cornerstone Baptist Church of Sikeston INC | Religion-Related | $0 | $0 |
| 92 | Allegro Music Club | Arts, Culture & Humanities | $0 | $0 |
| 93 | Heartland Advanced Practice Nurses Network | Education | $0 | $0 |
| 94 | Old Bethel Baptist Church | Unclassified | $0 | $0 |
| 95 | International Association of Sheet Metal Air Rail & Transportation | Employment | $0 | $0 |
| 96 | Kiwanis International INC | Unclassified | $0 | $0 |
| 97 | United Steelworkers | Unclassified | $0 | $0 |
| 98 | Agape Love Kingdom Ministries | Religion-Related | $0 | $0 |
| 99 | Shrm of Southeast Missouri | Employment | $0 | $0 |
| 100 | Laundry Baskets Full of Love - Not for Profit | Human Services | $0 | $0 |