| 1 | Hannibal Regional Healthcare System INC | Health Care | $302.9M | $199.3M |
| 2 | Mark Twain Association for Mental Health INC | Mental Health & Crisis Intervention | $38.9M | $82.5M |
| 3 | Hannibal-lagrange University | Education | $14.3M | $24.8M |
| 4 | Douglass Community Services INC | Human Services | $13.1M | $6.6M |
| 5 | Mennonite Home Association INC | Health Care | $9.2M | $5.7M |
| 6 | Northeast Independent Living Services | Unclassified | $6.7M | $2.9M |
| 7 | Luther Manor Association | Unclassified | $5.1M | $4.2M |
| 8 | Young Men Christian Association | Human Services | $4.1M | $5.5M |
| 9 | Marion County Services INC | Unclassified | $3.3M | $5.1M |
| 10 | Beth Haven Group Home INC | Human Services | $2.2M | $2.1M |
| 11 | Hannibal Reional Foundation | Unclassified | $2.0M | $5.3M |
| 12 | Mark Twain Home Foundation | Arts, Culture & Humanities | $1.9M | $7.3M |
| 13 | Hannibal Area Council of Aging | Human Services | $1.4M | $698K |
| 14 | Skills Development INC | Employment | $1.1M | $2.6M |
| 15 | Avenues INC | Human Services | $869K | $684K |
| 16 | Edward E Vincent Tr Fbo University of Missouri | Philanthropy, Voluntarism & Grantmaking | $856K | $2.6M |
| 17 | Bradley H Stutz Memorial Scholarship Test Tr | Education | $852K | $970K |
| 18 | Beth Haven Terrace INC | Unclassified | $772K | $1.0M |
| 19 | Hannibal Country Club | Unclassified | $769K | $292K |
| 20 | Stones Prairie Foundation | Philanthropy, Voluntarism & Grantmaking | $762K | $1.8M |
| 21 | George H Riedel Foundation | Philanthropy, Voluntarism & Grantmaking | $606K | $4.4M |
| 22 | Edward E Vincent Tr Fbo Missouri Western State University | Education | $580K | $1.8M |
| 23 | Mary Bell T Gentry Fbo Northeast Missouri Humane Society | Philanthropy, Voluntarism & Grantmaking | $568K | $1.7M |
| 24 | Families and Communities Together INC of Marion County Missouri | Human Services | $557K | $474K |
| 25 | Northeast Missouri Humane Society | Animal-Related | $519K | $3.0M |
| 26 | Hannibal Hospital Auxiliary | Health Care | $495K | $156K |
| 27 | Hannibal Arts Council | Unclassified | $440K | $1.2M |
| 28 | John and Mary McCue Childrens Trust | Philanthropy, Voluntarism & Grantmaking | $433K | $1.4M |
| 29 | Lois Eleanor Neff Foundation | Philanthropy, Voluntarism & Grantmaking | $427K | $1.2M |
| 30 | United Way of the Mark Twain Area | Unclassified | $375K | $577K |
| 31 | Paul W Evelyn J and Stephen Paul Butcher Memorial Foundation | Philanthropy, Voluntarism & Grantmaking | $364K | $796K |
| 32 | International Brotherhood of Electrical Workers | Unclassified | $344K | $1.1M |
| 33 | Ne Mo Sheltered Workshop INC | Unclassified | $289K | $168K |
| 34 | Ann Kirn Charitable Trust 719-74C29 | Human Services | $267K | $411K |
| 35 | Earl and Clara Kibbey Foundation | Philanthropy, Voluntarism & Grantmaking | $208K | $1.2M |
| 36 | Veterans of Foreign Wars Dept of Missouri | Unclassified | $206K | $104K |
| 37 | Harvest Outreach Ministries INC | Religion-Related | $197K | $360K |
| 38 | Pearl Lowrie Student Loan Fund U W | Unclassified | $181K | $718K |
| 39 | Missouri Association of Community Arts Agencies | Unclassified | $174K | $65K |
| 40 | Hannibal High School Booster Club | Community Improvement & Capacity Building | $169K | $114K |
| 41 | Compassion Church Hannibal | Religion-Related | $139K | $12K |
| 42 | Hannibal Area Chamber of Commerce | Unclassified | $131K | $71K |
| 43 | Rotary International | Unclassified | $115K | $68K |
| 44 | Bernard & Anna Clayton Scholarship Trust | Unclassified | $113K | $219K |
| 45 | Hannibal Free Clinic INC | Health Care | $108K | $244K |
| 46 | Benevolent & Protective Order of Elks of the USA | Unclassified | $108K | $90K |
| 47 | Bluff City Theater | Arts, Culture & Humanities | $103K | $14K |
| 48 | Mount Olivet Cemetary Association | Unclassified | $89K | $70K |
| 49 | Cuddle Cat Rescue | Animal-Related | $77K | $29K |
| 50 | Historic Hannibal Marketing Council | Unclassified | $73K | $71K |
| 51 | Embrace Children & Families | Human Services | $68K | $119K |
| 52 | Chart Teen Task Force | Human Services | $43K | $99K |
| 53 | International Association of Lions Clubs | Unclassified | $40K | $75K |
| 54 | Kiwanis Club of Hannibal Foundation | Human Services | $38K | $56K |
| 55 | Gene and Donna Evans Foundation | Philanthropy, Voluntarism & Grantmaking | $35K | $47K |
| 56 | P Michael McKay and Margaret R McKay Charitable Tr | Education | $12K | $117K |
| 57 | Kiwanis International INC | Unclassified | $10K | $11K |
| 58 | L Pearl Pensoneau Trust | Unclassified | $6K | $123K |
| 59 | Holy Family Catholic Foundation | Philanthropy, Voluntarism & Grantmaking | $5K | $59K |
| 60 | Pearl Lowrie Trust Uw Fbo | Unclassified | $4K | $85K |
| 61 | Mo Aprn Fpa | Health Care | $2K | $305 |
| 62 | Mary Frances Dunlop Scholarship Trust Hannibal Natl Bank Ttee | Unclassified | $2K | $34K |
| 63 | Rainbows for Hope | Human Services | $2K | $219 |
| 64 | Friends of the Hannibal Free Public Library | Education | $313 | $1K |
| 65 | Robinson Cemetery Association of Hannibal Missouri | Mutual & Membership Benefit | $285 | $1 |
| 66 | Evans Family Foundation | Unclassified | $200 | $1K |
| 67 | Sara M Zimmerman Foundation | Philanthropy, Voluntarism & Grantmaking | $1 | $1 |
| 68 | Destined to Win | Religion-Related | $0 | $0 |
| 69 | VFW Auxiliary Department of Missouri | Unclassified | $0 | $0 |
| 70 | National Rural Letter Carriers Association | Unclassified | $0 | $0 |
| 71 | Hannibal Concert Association INC | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 72 | Foundation of Missouri Jaycees Assn. | Unclassified | $0 | $0 |
| 73 | Hannibal Riverview | Unclassified | $0 | $0 |
| 74 | Ancient Free & Accepted Masons of Missouri | Unclassified | $0 | $0 |
| 75 | Ancient Free & Accepted Masons of Missouri | Unclassified | $0 | $0 |
| 76 | Aglow International | Unclassified | $0 | $0 |
| 77 | Granted Ministries | Religion-Related | $0 | $0 |
| 78 | Big Creek Presbyterian Church | Unclassified | $0 | $0 |
| 79 | Activities Directors Association of Missouri | Community Improvement & Capacity Building | $0 | $0 |
| 80 | Future Farmers of America and Its State Associations & Local Chapter | Unclassified | $0 | $0 |
| 81 | Hoopie Rose Foundation INC | Health Care | $0 | $0 |
| 82 | John Richter Cemetery Association | Mutual & Membership Benefit | $0 | $0 |
| 83 | Local Union 350 IBEW Building Corporation | Employment | $0 | $0 |
| 84 | Hannibal Storm Basketball | Recreation & Sports | $0 | $0 |
| 85 | Bruce Barton Memorial Scholarship F Und | Education | $0 | $0 |
| 86 | Mission 180 | Religion-Related | $0 | $0 |
| 87 | Believers Church of Hannibal | Unclassified | $0 | $0 |
| 88 | Knights of Columbus | Unclassified | $0 | $0 |
| 89 | St. Johns Lodge No 28 a F & a M | Mutual & Membership Benefit | $0 | $0 |
| 90 | First Christian Church | Unclassified | $0 | $0 |
| 91 | Board of Trustees | Religion-Related | $0 | $0 |
| 92 | Calvary Baptist Church Hannibal | Unclassified | $0 | $0 |
| 93 | Immanuel Baptist Church Hannibal | Unclassified | $0 | $0 |
| 94 | Executive Board of the Missouri Baptist Convention | Unclassified | $0 | $0 |
| 95 | First United Methodist Church | Unclassified | $0 | $0 |
| 96 | Willow Street Christian Church | Unclassified | $0 | $0 |
| 97 | West Side Christian Church of Hannibal Mo INC | Unclassified | $0 | $0 |
| 98 | Kiwanis International INC | Unclassified | $0 | $0 |
| 99 | South Side Baptist Church | Unclassified | $0 | $0 |
| 100 | Gods Harvesters INC | Unclassified | $0 | $0 |