| 1 | Smdc Medical Center | Health Care | $797.6M | $1.1B |
| 2 | St. Marys Medical Center | Health Care | $647.7M | $1.0B |
| 3 | Essentia Health | Health Care | $502.2M | $869.7M |
| 4 | Duluth Clinic Ltd | Health Care | $299.3M | $137.3M |
| 5 | St. Lukes Hospital of Duluth | Health Care | $272.1M | $536.1M |
| 6 | College of St. Scholastica INC | Education | $172.7M | $210.7M |
| 7 | Members Cooperative Credit Union | Unclassified | $93.2M | $1.2B |
| 8 | Irving Community Club Association | Unclassified | $36.4M | $293K |
| 9 | Second Harvest Northern Lakes Food Bank | Unclassified | $32.9M | $25.8M |
| 10 | Allete and Affiliated Companies Employees Medical Plan | Unclassified | $32.5M | $4.6M |
| 11 | Human Development Center | Mental Health & Crisis Intervention | $31.1M | $22.1M |
| 12 | Northland Foundation | Philanthropy, Voluntarism & Grantmaking | $30.9M | $124.7M |
| 13 | Benedictine Health Center | Unclassified | $29.0M | $54.0M |
| 14 | Northwood Childrens Home Society INC | Human Services | $27.0M | $34.5M |
| 15 | Residential Services of Northeastern Minnesota INC | Human Services | $25.5M | $13.0M |
| 16 | Lloyd K Johnson Foundation | Philanthropy, Voluntarism & Grantmaking | $24.0M | $31.0M |
| 17 | Duluth Regional Care Center INC | Unclassified | $21.6M | $15.3M |
| 18 | Duluth Health Services | Health Care | $20.8M | $22.7M |
| 19 | Northeast Entrepreneur Fund INC | Unclassified | $20.6M | $83.4M |
| 20 | Duluth Superior Area Community Foundation INC | Philanthropy, Voluntarism & Grantmaking | $16.6M | $118.0M |
| 21 | Center City Housing Corporation | Unclassified | $16.5M | $62.3M |
| 22 | True North Goodwill Northern Minnesota and Northwestern Wiscons | Employment | $16.2M | $11.9M |
| 23 | Duluth Area Family Y M C a | Human Services | $16.1M | $23.3M |
| 24 | Rural Health Resource Center | Health Care | $15.9M | $4.7M |
| 25 | Duluth Public Schools Academy | Education | $15.8M | $6.4M |
| 26 | Lake Superior Community Health Center | Health Care | $15.0M | $16.0M |
| 27 | One Roof Community Housing | Housing & Shelter | $14.6M | $23.5M |
| 28 | Essentia Health Foundation | Health Care | $14.5M | $24.2M |
| 29 | Center for Alcohol & Drug Treatment INC | Mental Health & Crisis Intervention | $14.3M | $8.8M |
| 30 | Essentia Institute of Rural Health | Medical Research | $13.3M | $6.7M |
| 31 | Marshall School | Unclassified | $13.3M | $21.1M |
| 32 | Ordean Foundation | Unclassified | $11.4M | $42.6M |
| 33 | Essentia Health Surgery Centers | Health Care | $10.4M | $33.4M |
| 34 | Allete and Affiliated Companies Retirees Health Plan a | Unclassified | $10.2M | $53.4M |
| 35 | Duluth Graduate Medical Education Council INC | Unclassified | $10.0M | $7.2M |
| 36 | Polinsky Medical Rehabilitation Center | Health Care | $9.9M | $13.0M |
| 37 | Miller Dwan Foundation | Health Care | $9.7M | $35.9M |
| 38 | Allete and Affiliated Companies Retirees Health Plan B | Unclassified | $8.9M | $58.4M |
| 39 | Duluth Playhouse INC | Arts, Culture & Humanities | $8.6M | $27.1M |
| 40 | Minnesota Power Employees Credit Union | Unclassified | $8.5M | $160.2M |
| 41 | Harbor Pointe Credit Union | Unclassified | $7.6M | $144.0M |
| 42 | Glen Avon Hockey Club | Unclassified | $7.4M | $257K |
| 43 | Northern Communities Credit Union | Unclassified | $7.3M | $108.5M |
| 44 | Northland Country Club | Unclassified | $7.3M | $6.4M |
| 45 | Arc Northland | Unclassified | $6.9M | $2.5M |
| 46 | Covenant Enabling Residences of Minnesota | Unclassified | $6.6M | $6.2M |
| 47 | Duluth Softball Players Assoc | Recreation & Sports | $5.6M | $88K |
| 48 | Legal Aid Service of Northeastern Minnesota | Crime & Legal-Related | $5.5M | $1.6M |
| 49 | Churches United in Ministry | Unclassified | $5.3M | $3.3M |
| 50 | Lake Superior Center | Environment | $5.2M | $2.4M |
| 51 | North Shore Community School | Education | $5.1M | $3.1M |
| 52 | Duluth-superior Area Educational Television Corporation | Arts, Culture & Humanities | $4.7M | $2.8M |
| 53 | University Nursery School | Unclassified | $4.7M | $791K |
| 54 | Aftenro Society | Unclassified | $4.3M | $4.1M |
| 55 | Grandmas Marathon Duluth INC | Unclassified | $4.0M | $4.8M |
| 56 | Northwood Foundation | Unclassified | $3.9M | $26.7M |
| 57 | American Indian Community Housing Organization | Housing & Shelter | $3.8M | $8.9M |
| 58 | Onan Family Foundation | Unclassified | $3.7M | $4.6M |
| 59 | Choice Unlimited | Employment | $3.7M | $2.7M |
| 60 | Marshall H and Nellie Alworth Memorial Fund | Unclassified | $3.7M | $18.4M |
| 61 | Duluth Bethel Society | Unclassified | $3.3M | $627K |
| 62 | Lighthouse Center for Vital Living | Diseases, Disorders & Medical Disciplines | $3.3M | $6.3M |
| 63 | Generations Health Care Initiatives INC | Health Care | $3.2M | $12.8M |
| 64 | Share Advantage Credit Uinon | Unclassified | $3.2M | $56.4M |
| 65 | Harbor City International Charter School | Education | $3.2M | $2.4M |
| 66 | Life House Incorporated | Youth Development | $3.1M | $3.7M |
| 67 | Lake Superior Zoological Society | Animal-Related | $3.0M | $2.0M |
| 68 | Hermantown Youth Soccer Association INC | Recreation & Sports | $3.0M | $499K |
| 69 | Safe Haven Shelter for Battered Women | Human Services | $2.9M | $6.0M |
| 70 | Many Rivers Montessori | Education | $2.9M | $4.1M |
| 71 | Duluth Area Family YMCA Heritage Foundation INC | Human Services | $2.8M | $9.7M |
| 72 | Ridgeview Country Club INC | Unclassified | $2.7M | $4.9M |
| 73 | Duluth & North Shore Railway INC | Arts, Culture & Humanities | $2.6M | $411K |
| 74 | Reservoir Riders INC | Unclassified | $2.6M | $455K |
| 75 | Community Action Duluth | Unclassified | $2.6M | $706K |
| 76 | American Legion | Unclassified | $2.6M | $277K |
| 77 | Lakeview Christian Academy INC | Unclassified | $2.5M | $608K |
| 78 | International Brotherhood of Teamsters | Unclassified | $2.5M | $5.2M |
| 79 | Animal Allies Humane Society INC | Animal-Related | $2.5M | $3.3M |
| 80 | Beck Foundation of Dsaet | Arts, Culture & Humanities | $2.4M | $19.7M |
| 81 | Kitchi Gammi Club | Unclassified | $2.4M | $3.0M |
| 82 | Gnesen Volunteer Fire Department INC | Public Safety, Disaster Preparedness & Relief | $2.3M | $1.1M |
| 83 | Zeitgeist Center for Arts and Community | Arts, Culture & Humanities | $2.2M | $16.3M |
| 84 | Union Gospel Mission Incorporated | Unclassified | $2.2M | $1.6M |
| 85 | Duluth Library Foundation | Education | $2.2M | $2.5M |
| 86 | Bentleyville Tour of Lights INC | Religion-Related | $2.0M | $814K |
| 87 | United Association of Journeymen & Apprentices of the Plumbing & Pipe | Unclassified | $2.0M | $5.1M |
| 88 | Boys Club of Duluth | Youth Development | $1.9M | $6.0M |
| 89 | Damiano of Duluth INC | Human Services | $1.9M | $4.0M |
| 90 | Northspan Group Incorporated | Unclassified | $1.8M | $382K |
| 91 | Young Womens Christian Association | Human Services | $1.8M | $3.0M |
| 92 | Midwest Medical Equipment & Supplies INC | Health Care | $1.8M | $1.2M |
| 93 | Ecolibrium3 | Environment | $1.8M | $1.6M |
| 94 | Program to Aid for Victims of Sexual Assault | Unclassified | $1.7M | $1.1M |
| 95 | Duluth 1200 Fund INC | Unclassified | $1.7M | $4.3M |
| 96 | First Witness Child Advocacy Center | Crime & Legal-Related | $1.7M | $4.6M |
| 97 | Head of the Lakes United Way | Philanthropy, Voluntarism & Grantmaking | $1.7M | $8.5M |
| 98 | International Brotherhood of Electrical Workers | Unclassified | $1.7M | $5.0M |
| 99 | Udac INC | Unclassified | $1.6M | $5.6M |
| 100 | Faith Haven Incorporated | Housing & Shelter | $1.5M | $2.6M |