| 1 | Allegiance Health | Health Care | $961.5M | $945.2M |
| 2 | True Community Credit Union | Unclassified | $81.5M | $880.5M |
| 3 | Credit Unions Chartered in the State of Michigan | Unclassified | $66.4M | $660.9M |
| 4 | Center for Family Health | Health Care | $39.6M | $29.4M |
| 5 | Alro Steel Foundation | Philanthropy, Voluntarism & Grantmaking | $34.4M | $80.8M |
| 6 | Jackson Community Foundation | Philanthropy, Voluntarism & Grantmaking | $31.3M | $55.1M |
| 7 | Consumers Energy Foundation | Unclassified | $29.1M | $67.1M |
| 8 | Cascade Pace INC | Human Services | $23.4M | $9.8M |
| 9 | The Alvin L Glick Foundation | Philanthropy, Voluntarism & Grantmaking | $22.3M | $52.3M |
| 10 | Vista Grande Villa | Unclassified | $18.7M | $20.8M |
| 11 | Community Action Agency | Human Services | $18.1M | $5.1M |
| 12 | Christ Centered Home INC | Human Services | $13.1M | $5.0M |
| 13 | Ella Sharp Museum Association of Jackson | Arts, Culture & Humanities | $11.0M | $7.0M |
| 14 | Lingap Childrens Foundation | International, Foreign Affairs & National Security | $7.1M | $14.5M |
| 15 | Pdhcrc INC | Human Services | $6.4M | $3.8M |
| 16 | Country Club of Jackson | Unclassified | $6.1M | $8.4M |
| 17 | Jackson Community College Foundation | Education | $5.5M | $24.2M |
| 18 | Catholic Charities of Jackson Lenawee and Hillsdale Counties | Human Services | $5.1M | $3.3M |
| 19 | Credit Unions Chartered in the State of Michigan | Unclassified | $4.6M | $83.6M |
| 20 | Segue INC | Mental Health & Crisis Intervention | $4.2M | $5.0M |
| 21 | Child & Family Services of Michigan | Unclassified | $4.2M | $1.5M |
| 22 | Hurst Foundation | Unclassified | $4.1M | $11.7M |
| 23 | St. George Foundation for the Classics | Unclassified | $4.0M | $3.6M |
| 24 | Jackson Y-center INC | Human Services | $3.9M | $27.9M |
| 25 | Jackson Area Manufacturers Association | Human Services | $3.8M | $3.1M |
| 26 | Particular Council of Jackson | Unclassified | $3.2M | $2.3M |
| 27 | Bill & VI Sigmund Foundation | Philanthropy, Voluntarism & Grantmaking | $3.1M | $7.3M |
| 28 | Credit Unions Chartered in the State of Michigan | Unclassified | $2.6M | $50.5M |
| 29 | Smiles on Wheels | Health Care | $2.6M | $2.4M |
| 30 | Jackson Inter-faith Shelter | Housing & Shelter | $2.5M | $5.1M |
| 31 | Lansing Glaziers 826 Health & Welfare Fund | Unclassified | $2.3M | $1.1M |
| 32 | A R E INC of Jackson | Mental Health & Crisis Intervention | $2.2M | $570K |
| 33 | Royal Ministries INC | Education | $2.2M | $2.5M |
| 34 | Michigan Theatre of Jackson INC | Arts, Culture & Humanities | $2.2M | $6.7M |
| 35 | John George Home INC | Human Services | $2.0M | $2.8M |
| 36 | St. Joseph Home for Children | Unclassified | $2.0M | $1.5M |
| 37 | Habitat for Humanity International INC | Unclassified | $1.9M | $1.8M |
| 38 | Lean Rocket Lab | Community Improvement & Capacity Building | $1.9M | $1.2M |
| 39 | Cascades Humane Society INC | Animal-Related | $1.9M | $8.5M |
| 40 | Myer & Lois Franklin Charitable Tr | Unclassified | $1.8M | $6.0M |
| 41 | Jackson Friendly Home | Unclassified | $1.6M | $2.1M |
| 42 | Jackson Symphony Orchestra Association | Arts, Culture & Humanities | $1.4M | $1.4M |
| 43 | Enterprise Group of Jackson INC | Unclassified | $1.4M | $1.8M |
| 44 | Disability Connections INC | Human Services | $1.3M | $880K |
| 45 | Jackson County Visitor Bureau | Unclassified | $1.2M | $786K |
| 46 | Jackson County Chamber of Commerce | Unclassified | $1.2M | $964K |
| 47 | Aware INC | Human Services | $1.2M | $852K |
| 48 | Jackson Interfaith Nonprofit Housing Corporation | Unclassified | $1.1M | $3.0M |
| 49 | Jackson School of the Arts Association | Arts, Culture & Humanities | $1.1M | $4.1M |
| 50 | Jackson Optimist Charitable Fund INC | Youth Development | $1.0M | $1.4M |
| 51 | Michigan Braille Trans Fund INC | Human Services | $940K | $3.6M |
| 52 | Henry Ford Allegiance Health Group | Unclassified | $927K | $38.9M |
| 53 | Fraternal Order of Eagles | Unclassified | $792K | $1.2M |
| 54 | Nonprofit Network | Human Services | $755K | $357K |
| 55 | Dahlem Conservancy | Environment | $744K | $2.2M |
| 56 | College Access Center of Jackson INC | Education | $727K | $745K |
| 57 | Cascades Park Foundation | Recreation & Sports | $711K | $2.0M |
| 58 | Dochas II | Youth Development | $633K | $95K |
| 59 | Big Brothers Big Sisters of Jackson County INC | Unclassified | $604K | $1.0M |
| 60 | The Robert and Rose Glick Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $581K | $2.8M |
| 61 | Myplace INC | Housing & Shelter | $566K | $332K |
| 62 | Disability Connections Foundation of Jackson County | Human Services | $557K | $2.7M |
| 63 | Mission of Hope Cancer Fund | Human Services | $547K | $160K |
| 64 | Compassionate Ministries of Jackson County | Human Services | $544K | $1.1M |
| 65 | Faith F Small Foundation Tr | Philanthropy, Voluntarism & Grantmaking | $540K | $4K |
| 66 | Joseph & Lottie Michner Educational Foundation | Unclassified | $504K | $578K |
| 67 | Great Lakes Burn Camp | Recreation & Sports | $504K | $1.3M |
| 68 | Jackson County 4-H Foundation INC | Human Services | $495K | $855K |
| 69 | Allan B Copley Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $487K | $932K |
| 70 | Samuel Higby Camp Foundation | Unclassified | $481K | $2.0M |
| 71 | Jackson Symphony Orchestra Association Foundation INC | Arts, Culture & Humanities | $479K | $7.8M |
| 72 | Phantom Foundation | Philanthropy, Voluntarism & Grantmaking | $469K | $549K |
| 73 | Cms Energy Foundation | Philanthropy, Voluntarism & Grantmaking | $458K | $2.5M |
| 74 | Pilgrim Foundation Tr U-a | Philanthropy, Voluntarism & Grantmaking | $440K | $6.8M |
| 75 | Jackson Christian Early Learning Centers INC | Education | $428K | $331K |
| 76 | Junior Achievement of the Michigan Edge | International, Foreign Affairs & National Security | $426K | $202K |
| 77 | Lily Missions Center | Human Services | $422K | $1.2M |
| 78 | Jackson Area Hockey Association | Recreation & Sports | $405K | $160K |
| 79 | Hope House II a Non Profit Housing Corp. | Human Services | $405K | $710K |
| 80 | Soar Cafe and Farms | Crime & Legal-Related | $395K | $710K |
| 81 | Andys Angels | Education | $373K | $341K |
| 82 | Fraternal Order of Eagles | Unclassified | $369K | $64K |
| 83 | Residents in Action INC | Human Services | $362K | $62K |
| 84 | American Legion | Unclassified | $355K | $282K |
| 85 | Hope House I INC | Human Services | $351K | $481K |
| 86 | Chesterton Foundation of St. George | Education | $349K | $26K |
| 87 | Spring Meadows II Senior Non-profit Housing Corporation | Housing & Shelter | $348K | $2.4M |
| 88 | Grow Jackson | Food, Agriculture & Nutrition | $347K | $31K |
| 89 | Southeastern Dispute Resolution Services | Human Services | $344K | $88K |
| 90 | Enterprise Group Community Ventures Corporation | Community Improvement & Capacity Building | $309K | $85K |
| 91 | Salt and Light Global | Public & Societal Benefit | $308K | $526K |
| 92 | Elara Caring Hospice Foundation | Human Services | $307K | $813K |
| 93 | Open Door Adoption Services | Human Services | $299K | $190K |
| 94 | Christ Housing Community | Religion-Related | $295K | $1.7M |
| 95 | Addison P Cook III Foundation | Philanthropy, Voluntarism & Grantmaking | $257K | $4.0M |
| 96 | Center for Women Pregnancy Counseling Services INC | Health Care | $235K | $607K |
| 97 | Carelink of Jackson a Community Owned Specialty Hospital | Health Care | $230K | $0 |
| 98 | Great Lakes Renegades | Recreation & Sports | $227K | $55K |
| 99 | American Legion | Mutual & Membership Benefit | $224K | $866K |
| 100 | Jackson Community Food Pantry | Food, Agriculture & Nutrition | $223K | $582K |