| 1 | Unity Healthcare | Health Care | $77.4M | $89.3M |
| 2 | Roy J Carver Charitable Tr | Unclassified | $72.4M | $236.7M |
| 3 | The Stanley Foundation | Philanthropy, Voluntarism & Grantmaking | $26.4M | $134.5M |
| 4 | Community Foundation of Greater Muscatine | Philanthropy, Voluntarism & Grantmaking | $21.4M | $93.4M |
| 5 | Lutheran Homes Society | Unclassified | $16.6M | $29.3M |
| 6 | Tax Education Support Organization | Public & Societal Benefit | $14.6M | $44.7M |
| 7 | Crossroads INC of Muscatine | Employment | $5.3M | $2.6M |
| 8 | New Hope Foundation | Unclassified | $5.2M | $25.5M |
| 9 | Holthues Tr | Philanthropy, Voluntarism & Grantmaking | $4.2M | $26.6M |
| 10 | Howe Foundation | Unclassified | $3.5M | $7.9M |
| 11 | Muscatine Center for Social Action | Community Improvement & Capacity Building | $2.8M | $4.5M |
| 12 | Muscatine Community Y | Human Services | $2.7M | $16.5M |
| 13 | Robert S Jackson Trust Central State Bank Ttee | Unclassified | $2.2M | $7.7M |
| 14 | Geneva Golf & Country Club | Unclassified | $2.1M | $2.7M |
| 15 | Kent Corporation Charitable Foundation | Unclassified | $2.0M | $88K |
| 16 | Hni Charitable Foundation | Unclassified | $2.0M | $3.0M |
| 17 | Unity Healthcare Foundation | Philanthropy, Voluntarism & Grantmaking | $2.0M | $1.7M |
| 18 | United Way of Muscatine Iowa Incorporated | Unclassified | $1.3M | $934K |
| 19 | Jensen Private Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.1M | $7.9M |
| 20 | Muscatine Community College Foundation | Education | $1.0M | $22.3M |
| 21 | Youth Sports Foundation | Recreation & Sports | $1.0M | $1.6M |
| 22 | Greater Muscatine Chamber of Commerce and Industry | Unclassified | $888K | $932K |
| 23 | It Takes a Village Animal Rescue & Resources | Animal-Related | $847K | $14K |
| 24 | Muscatine Humane Society INC | Animal-Related | $598K | $1.8M |
| 25 | Iowa Farm Bureau Federation | Unclassified | $580K | $1.8M |
| 26 | Benjamin Hershey Memorial Convalescent Home | Unclassified | $512K | $3.5M |
| 27 | Muscatine Christian Academy | Education | $397K | $12K |
| 28 | Stanley Consultants Charitable Foundation | Unclassified | $391K | $841K |
| 29 | Friends of the Muscatine Ffa | Education | $384K | $226K |
| 30 | Muscatine Humane Society INC Endowment Trust | Animal-Related | $380K | $2.3M |
| 31 | Churches United of the Quad City Area Hunger Ministries Fund | Human Services | $364K | $966K |
| 32 | United Marriage Encounter | Human Services | $319K | $719K |
| 33 | Marriage Encounter Support Foundation | Human Services | $299K | $7.1M |
| 34 | American Legion | Unclassified | $295K | $320K |
| 35 | Jhk Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $263K | $2.6M |
| 36 | Muscatine Community School District Veba Trust | Mutual & Membership Benefit | $248K | $290K |
| 37 | Mary M Nietzel Trust | Religion-Related | $246K | $806K |
| 38 | Katherine B Hahn Trust | Unclassified | $238K | $781K |
| 39 | Diversity Service Center of Iowa | Human Services | $224K | $175K |
| 40 | Rebuilding Together-muscatine | Housing & Shelter | $218K | $129K |
| 41 | Muscatine Welfare Assoc | Housing & Shelter | $213K | $1.2M |
| 42 | Muscatine Chamber of Commerce Foundation | Philanthropy, Voluntarism & Grantmaking | $209K | $212K |
| 43 | St. Marys Cemetery Association of Muscatine Iowa | Unclassified | $200K | $233K |
| 44 | Muscatine Soccer Club | Recreation & Sports | $181K | $107K |
| 45 | Historic Muscatine INC | Unclassified | $166K | $1.5M |
| 46 | Seal Family Legacy INC | Public & Societal Benefit | $151K | $140K |
| 47 | Wilton Community Foundation | Philanthropy, Voluntarism & Grantmaking | $150K | $725K |
| 48 | Trinity Muscatine Friends | Unclassified | $149K | $288K |
| 49 | Muscatine Legal Services | Crime & Legal-Related | $145K | $93K |
| 50 | Helen M Little Trust | Unclassified | $142K | $555K |
| 51 | Frank C & Mary Esther Bishop Educational Tr | Philanthropy, Voluntarism & Grantmaking | $137K | $3.0M |
| 52 | Crossroads Foundation | Human Services | $136K | $7.7M |
| 53 | Aldean Chaplin Memorial Trust | Unclassified | $135K | $899K |
| 54 | Churches United of the Quad City Area Winnies Place Fund | Human Services | $134K | $352K |
| 55 | Muscatine Board of Realtors INC | Community Improvement & Capacity Building | $130K | $164K |
| 56 | Muscatine Symphony Orchestra Assoc | Arts, Culture & Humanities | $129K | $171K |
| 57 | Muscatine Band Boosters | Unclassified | $124K | $129K |
| 58 | Pearl City Outreach | Civil Rights, Social Action & Advocacy | $110K | $16K |
| 59 | A J Magnus Home | Unclassified | $98K | $568K |
| 60 | Muskie Baseball Academy | Recreation & Sports | $90K | $20K |
| 61 | Flickinger Learning Center | Human Services | $87K | $234K |
| 62 | Literally Athletic Building | Human Services | $86K | $213K |
| 63 | Muscatine Choral Boosters | Education | $84K | $50K |
| 64 | Sino-us Friendship House | Arts, Culture & Humanities | $73K | $28K |
| 65 | Monsters Fastpitch | Recreation & Sports | $73K | $12K |
| 66 | Marek Trust Fund | Unclassified | $64K | $182K |
| 67 | Muskie Football Club INC | Unclassified | $44K | $51K |
| 68 | Theo Wolf Foundation | Public Safety, Disaster Preparedness & Relief | $40K | $68K |
| 69 | Rotary International | Unclassified | $36K | $33K |
| 70 | Stanley Scholarship Trust | Unclassified | $26K | $75K |
| 71 | Michels Fam Educational Tr | Philanthropy, Voluntarism & Grantmaking | $11K | $289K |
| 72 | Beitz Foundation | Education | $9K | $95K |
| 73 | Erika Kate Foundation | Philanthropy, Voluntarism & Grantmaking | $146 | $45K |
| 74 | Central Bancshares Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $1 | $1 |
| 75 | Muscatine Orchestra Boosters | Education | $0 | $0 |
| 76 | Muscatine Productions Boosters | Education | $0 | $0 |
| 77 | New Evangelization Ministries | Religion-Related | $0 | $0 |
| 78 | United States Bowling Congress INC | Recreation & Sports | $0 | $0 |
| 79 | International Association of Fire Fighters | Unclassified | $0 | $0 |
| 80 | Toastmasters International | Unclassified | $0 | $0 |
| 81 | Catholic Daughters of the Americas | Unclassified | $0 | $0 |
| 82 | Muscatine Area Heritage Association INC | Unclassified | $0 | $0 |
| 83 | Friends of the Musser Public Library | Education | $0 | $0 |
| 84 | Church of the Living Water | Unclassified | $0 | $0 |
| 85 | Royal and Select Masters of Iowa | Unclassified | $0 | $0 |
| 86 | Royal Arch Masons of Iowa 4 Washington | Unclassified | $0 | $0 |
| 87 | Knights of Columbus | Unclassified | $0 | $0 |
| 88 | Friends of Muscatine Historic Preservation | Arts, Culture & Humanities | $0 | $0 |
| 89 | Hawk a Model a Ford Club | Unclassified | $0 | $0 |
| 90 | Great River Tennis Association | Recreation & Sports | $0 | $0 |
| 91 | Knights of Columbus | Mutual & Membership Benefit | $0 | $0 |
| 92 | Next Level - Basketball Advantage | Human Services | $0 | $0 |
| 93 | Fraternal Order of Eagles | Unclassified | $0 | $0 |
| 94 | Muscatine Youth Girls Basketball | Recreation & Sports | $0 | $0 |
| 95 | Carolina Hero Relief INC | Public Safety, Disaster Preparedness & Relief | $0 | $0 |
| 96 | Love Haven | Human Services | $0 | $0 |
| 97 | Port City Coin Club | Recreation & Sports | $0 | $0 |
| 98 | Muscatine Rugby Club | Youth Development | $0 | $0 |
| 99 | Muscatine Agility Club | Animal-Related | $0 | $0 |
| 100 | Department of Iowa Auxiliary to the Veterans of Foreign Wars | Public & Societal Benefit | $0 | $0 |