| 1 | Keokuk Area Hospital | Health Care | $21.9M | $5.2M |
| 2 | Keokuk Area Community Foundation | Philanthropy, Voluntarism & Grantmaking | $11.4M | $32.9M |
| 3 | Hoerner Young Mens Christian Association of Keokuk Iowa INC | Human Services | $803K | $2.8M |
| 4 | Howard Jackson Fam Tr Foundation | Philanthropy, Voluntarism & Grantmaking | $656K | $2.3M |
| 5 | Independent Baptist Indian Mission INC | Religion-Related | $558K | $94K |
| 6 | Keokuk Area Convention Center & Tourism Bureau Foundation | Arts, Culture & Humanities | $468K | $197K |
| 7 | Kyc INC | Recreation & Sports | $451K | $271K |
| 8 | International Association of Bridge Structural & Ornamental Ironworker | Unclassified | $451K | $1.5M |
| 9 | Keokuk Benevolent Union Home | Human Services | $445K | $1.1M |
| 10 | Habitat for Humanity International INC | Unclassified | $395K | $1.4M |
| 11 | Southside Boat Club | Unclassified | $386K | $379K |
| 12 | United Way of the Great River Region | Unclassified | $372K | $537K |
| 13 | Keokuk Union Depot Foundation | Arts, Culture & Humanities | $276K | $42K |
| 14 | Grace Bott Millar Charitable Trust | Unclassified | $258K | $758K |
| 15 | Keokuk Economic Development Corporation | Community Improvement & Capacity Building | $252K | $638K |
| 16 | Benevolent & Protective Order of Elks of the USA | Unclassified | $238K | $243K |
| 17 | Keokuk Community Child Development Center INC | Human Services | $238K | $62K |
| 18 | Main Street Keokuk INC | Philanthropy, Voluntarism & Grantmaking | $179K | $412K |
| 19 | Iron Workers Local 577 Joint Apprenticeship Committee | Unclassified | $177K | $279K |
| 20 | Talbot Home for Sober Living | Mental Health & Crisis Intervention | $177K | $144K |
| 21 | Keokuk Public Library Foundation | Unclassified | $158K | $1.8M |
| 22 | Keokuk Homeless Alliance INC | Housing & Shelter | $151K | $201K |
| 23 | United Steelworkers | Unclassified | $104K | $98K |
| 24 | Black Dragons INC | Recreation & Sports | $91K | $15K |
| 25 | Bakery Confectionery Tobacco | Unclassified | $89K | $147K |
| 26 | Keokuk XII | Philanthropy, Voluntarism & Grantmaking | $87K | $24K |
| 27 | Inside Out Christian Counseling | Mental Health & Crisis Intervention | $82K | $35K |
| 28 | Chamber of Commerce | Unclassified | $77K | $85K |
| 29 | Lake Cooper Foundation | Arts, Culture & Humanities | $74K | $87K |
| 30 | United Steelworkers | Unclassified | $62K | $40K |
| 31 | Sound in Spirit Broadcasting INC | Arts, Culture & Humanities | $62K | $97K |
| 32 | Keokuk Humane Society | Animal-Related | $52K | $555K |
| 33 | Kplay Playgrounds for All | Recreation & Sports | $49K | $10K |
| 34 | Great River Players INC | Arts, Culture & Humanities | $46K | $195K |
| 35 | Independent Order of Odd Fellows | Unclassified | $44K | $473K |
| 36 | Lorene Curtis Diver Memorial Trust | Unclassified | $9K | $120K |
| 37 | The Chase and Conor Piper Memorial Foundation | Crime & Legal-Related | $7K | $77K |
| 38 | Jackson Township Fire Association | Public Safety, Disaster Preparedness & Relief | $0 | $0 |
| 39 | United States Bowling Congress INC | Recreation & Sports | $0 | $0 |
| 40 | Keokuk Church of Christ | Religion-Related | $0 | $0 |
| 41 | American Federation of State County & Municipal Employees | Unclassified | $0 | $0 |
| 42 | Keokuk Community Fine Arts Council | Unclassified | $0 | $0 |
| 43 | Ancient Free & Accepted Masons of Iowa | Unclassified | $0 | $0 |
| 44 | Standing Bear Council INC | Arts, Culture & Humanities | $0 | $0 |
| 45 | Family Worship Center | Unclassified | $0 | $0 |
| 46 | Rand Park Pavilion Commission | Recreation & Sports | $0 | $0 |
| 47 | Mt Olive Missionary Baptist Church | Religion-Related | $0 | $0 |
| 48 | Golden Oak Society | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 49 | Keokuk Historic Preservation Commission | Arts, Culture & Humanities | $0 | $0 |
| 50 | Keokuk Athletic Booster | Recreation & Sports | $0 | $0 |
| 51 | Keokuk Cares | Human Services | $0 | $0 |
| 52 | Keokuk Assembly of God | Unclassified | $0 | $0 |
| 53 | Knights of Columbus | Unclassified | $0 | $0 |
| 54 | American Legion | Unclassified | $0 | $0 |
| 55 | Keokuk Art Center | Arts, Culture & Humanities | $0 | $0 |
| 56 | Burlington Kennel Club INC | Animal-Related | $0 | $0 |
| 57 | First Christian Church | Unclassified | $0 | $0 |
| 58 | Organized Christian Workers | Unclassified | $0 | $0 |
| 59 | The Evangelical Free Church of Keokuk | Unclassified | $0 | $0 |
| 60 | Mississippi Terrace Tenant Association | Unclassified | $0 | $0 |
| 61 | Keokuk Concert Association | Unclassified | $0 | $0 |
| 62 | Faith Family Church of Keokuk Iowa | Religion-Related | $0 | $0 |
| 63 | Keokuk Foursquare Church | Unclassified | $0 | $0 |
| 64 | Birthright of Keokuk INC | Unclassified | $0 | $0 |
| 65 | Keokuk Education Association | Unclassified | $0 | $0 |
| 66 | American Legion Auxiliary | Unclassified | $0 | $0 |
| 67 | First Baptist Church | Unclassified | $0 | $0 |
| 68 | Heritage Center | Human Services | $0 | $0 |
| 69 | Child Abuse Prevention Council of Lee County | Human Services | $0 | $0 |
| 70 | Keokuk Little League INC | Recreation & Sports | $0 | $0 |
| 71 | Keokuk City of Christmas INC | Unclassified | $0 | $0 |
| 72 | Grand Theatre Corporate Foundation | Unclassified | $0 | $0 |
| 73 | Keokuk Community School Foundation | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 74 | Keokuk Saddle Club | Animal-Related | $0 | $0 |
| 75 | Keokuk Sister Cities Association INC | International, Foreign Affairs & National Security | $0 | $0 |
| 76 | Christ Apostolic Holiness Church | Unclassified | $0 | $0 |
| 77 | New Beginnings of Keokuk | Religion-Related | $0 | $0 |
| 78 | Keokuk History Center | Unclassified | $0 | $0 |
| 79 | Keokuk Area Hospital Auxiliary INC | Unclassified | $0 | $0 |
| 80 | American Association of University Women | Education | $0 | $0 |
| 81 | International Association of Fire Fighters | Unclassified | $0 | $0 |
| 82 | Ladies of Charity | Unclassified | $0 | $0 |
| 83 | International Association of Lions Clubs | Unclassified | $0 | $0 |
| 84 | Rotary International | Unclassified | $0 | $0 |
| 85 | New Testament Christian Church | Unclassified | $0 | $0 |
| 86 | America S First Great Dam Foundation INC | Human Services | $0 | $0 |
| 87 | Keokuk Parks Foundation | Recreation & Sports | $0 | $0 |
| 88 | Gospel Temple Church of God in Christ | Unclassified | $0 | $0 |
| 89 | Rolling on the River INC | Arts, Culture & Humanities | $0 | $0 |
| 90 | Keokuk Association for Rights and Equality | Civil Rights, Social Action & Advocacy | $0 | $0 |
| 91 | Ride with Levi | Youth Development | $0 | $0 |
| 92 | Friends of the Keokuk Animal Shelter | Animal-Related | $0 | $0 |
| 93 | Keokuk Neighborhood Initiative INC | Housing & Shelter | $0 | $0 |
| 94 | Mancountry | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 95 | Medicine Eagle Council INC | Education | $0 | $0 |
| 96 | Keokuk Animal Services Partners in Rescue INC | Animal-Related | $0 | $0 |
| 97 | Lydias House | Housing & Shelter | $0 | $0 |
| 98 | Acts 2-45 Closet | Human Services | $0 | $0 |
| 99 | Parent Booster USA INC | Education | $0 | $0 |
| 100 | Peace Love and Roots Community Garden | Food, Agriculture & Nutrition | $0 | $0 |