| 1 | Mercy Medical Center-centerville | Health Care | $53.5M | $72.8M |
| 2 | Rathbun Regional Water Association INC | Unclassified | $24.2M | $156.5M |
| 3 | Morgan E Cline Perpetual Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $6.8M | $15.0M |
| 4 | Centerville Community Betterment INC Zylpha Price House | Human Services | $3.6M | $6.1M |
| 5 | Centerville Chamber of Commerce | Unclassified | $1.2M | $3.0M |
| 6 | Centerville Housing INC | Unclassified | $617K | $485K |
| 7 | Appanoose County Day Care INC | Human Services | $594K | $418K |
| 8 | Appanoose County Foundation | Philanthropy, Voluntarism & Grantmaking | $527K | $1.4M |
| 9 | Centerville Community Schools Foundation | Education | $526K | $1.2M |
| 10 | Rathbun Lake Area YMCA | Human Services | $486K | $602K |
| 11 | Chariton Valley Regional Housing Trust Fund INC | Housing & Shelter | $462K | $1.2M |
| 12 | Appanoose Country Club | Unclassified | $325K | $316K |
| 13 | New Hope Counseling Center | Human Services | $325K | $639K |
| 14 | Appanoose County Community Railroad INC | Unclassified | $316K | $3.3M |
| 15 | Furever Friends Rescue of Appanoose INC | Animal-Related | $230K | $439K |
| 16 | Fraternal Order of Eagles | Unclassified | $181K | $7K |
| 17 | Rathbun Land and Water Alliance INC | Environment | $132K | $167K |
| 18 | Humble Heroes Foundation | Education | $114K | $66K |
| 19 | Appanoose Conservation Foundation | Environment | $101K | $856K |
| 20 | Iowa Farm Bureau Federation | Unclassified | $100K | $1.1M |
| 21 | Centerville Athletic Booster Club | Recreation & Sports | $89K | $91K |
| 22 | Centerville Concert Association | Arts, Culture & Humanities | $73K | $69K |
| 23 | Nami South Central Iowa | Human Services | $62K | $106K |
| 24 | Appanoose Industrial Corporation | Unclassified | $56K | $1.7M |
| 25 | Appanoose County Lord S Cupboard | Food, Agriculture & Nutrition | $45K | $200K |
| 26 | Walldog Public Art | Arts, Culture & Humanities | $8K | $241K |
| 27 | Anchored Inn | Unclassified | $1 | $1 |
| 28 | Friends of the Drake Public Library | Education | $0 | $0 |
| 29 | American Federation of State County & Municipal Employees | Unclassified | $0 | $0 |
| 30 | Evangelical Covenant Church Centerville Ia | Unclassified | $0 | $0 |
| 31 | Grow Centerville | Community Improvement & Capacity Building | $0 | $0 |
| 32 | Appanoose County Homeless Coalition | Housing & Shelter | $0 | $0 |
| 33 | Centerville Faith Church | Religion-Related | $0 | $0 |
| 34 | Prairie Lands Bio-products INC | Food, Agriculture & Nutrition | $0 | $0 |
| 35 | Appanoose All Play INC | Community Improvement & Capacity Building | $0 | $0 |
| 36 | Drake Avenue Christian Church | Unclassified | $0 | $0 |
| 37 | St. Marys Church | Unclassified | $0 | $0 |
| 38 | Appanoose County Historical Society | Arts, Culture & Humanities | $0 | $0 |
| 39 | Appanoose County United Way | Unclassified | $0 | $0 |
| 40 | The Appanoose County Ministerial Association | Unclassified | $0 | $0 |
| 41 | Knights of Columbus | Unclassified | $0 | $0 |
| 42 | New Directions INC | Unclassified | $0 | $0 |
| 43 | First Evangelical Lutheran Church | Unclassified | $0 | $0 |
| 44 | Knights of Columbus | Unclassified | $0 | $0 |
| 45 | Sharon Bluffs Bible Camp of the Churches of Christ | Unclassified | $0 | $0 |
| 46 | Little League Baseball INC | Unclassified | $0 | $0 |
| 47 | Appanoose County Genealogical Society | Unclassified | $0 | $0 |
| 48 | Golfview Addition Owners Associati N | Unclassified | $0 | $0 |
| 49 | Centerville Assemblyy of God | Unclassified | $0 | $0 |
| 50 | Appanoose County Shooting Club | Community Improvement & Capacity Building | $0 | $0 |
| 51 | Appanoose County Girls Softball INC | Recreation & Sports | $0 | $0 |
| 52 | Legacies | Unclassified | $0 | $0 |
| 53 | Historic Preservation Corporation | Arts, Culture & Humanities | $0 | $0 |
| 54 | Centerville Volunteers Fire Fighters Association | Public Safety, Disaster Preparedness & Relief | $0 | $0 |
| 55 | Reaching All People Together | Human Services | $0 | $0 |
| 56 | American Legion 0214 Ray C Walden Post | Unclassified | $0 | $0 |
| 57 | Rotary International | Unclassified | $0 | $0 |
| 58 | First Church of the Open Bible | Unclassified | $0 | $0 |
| 59 | International Association of Lions Clubs | Unclassified | $0 | $0 |
| 60 | Veterans of Foreign Wars of the United States Dept of Iowa | Unclassified | $0 | $0 |
| 61 | Centerville Garden Club | Environment | $0 | $0 |
| 62 | Lakeview PTO | Education | $0 | $0 |
| 63 | Drake Public Library Foundation | Education | $0 | $0 |
| 64 | Centerville Trap Team | Education | $0 | $0 |
| 65 | Hands of Ministry and Evangelism Church | Religion-Related | $0 | $0 |
| 66 | Appanoose County Trails INC | Community Improvement & Capacity Building | $0 | $0 |
| 67 | Centerville Performing Arts Boosters | Education | $0 | $0 |
| 68 | Appanoose County Fair Foundation INC | Recreation & Sports | $0 | $0 |
| 69 | Southern Iowa Girls Softball Association | Recreation & Sports | $0 | $0 |
| 70 | 18-80 Club | Human Services | $0 | $0 |
| 71 | Advancements in Counseling Education and Law | Mental Health & Crisis Intervention | $0 | $0 |
| 72 | Aaron Schaffer Jensen Family Foundation | Human Services | $0 | $0 |
| 73 | Women Helping Women | Arts, Culture & Humanities | $0 | $0 |
| 74 | Centerville Municipal Band | Arts, Culture & Humanities | $0 | $0 |
| 75 | Point of Light Ministries LLC | Religion-Related | $0 | $0 |
| 76 | Parent Booster USA INC | Education | $0 | $0 |