| 1 | Parkview Medical Center INC | Health Care | $1.2B | $617.8M |
| 2 | Goal Academy | Education | $79.5M | $66.2M |
| 3 | Parkview Health Systems INC | Health Care | $71.3M | $112K |
| 4 | San Isabel Electric Association INC | Unclassified | $62.4M | $224.5M |
| 5 | Pueblo Community Health Center INC | Unclassified | $50.6M | $54.6M |
| 6 | Health Solutions | Mental Health & Crisis Intervention | $45.0M | $30.7M |
| 7 | Chavez Huerta K-12 Preparatory Academy | Education | $33.1M | $76.5M |
| 8 | Crossroads Turning Points INC | Mental Health & Crisis Intervention | $21.3M | $17.8M |
| 9 | Sangre de Cristo Hospice & Palliative Care | Human Services | $19.6M | $13.9M |
| 10 | Colorado State University-pueblo Foundation | Education | $17.7M | $69.0M |
| 11 | Pueblo City-county Library District | Education | $14.2M | $61.9M |
| 12 | Robert Hoag Rawlings Foundation | Unclassified | $12.6M | $28.3M |
| 13 | Credit Unions Chartered in the State of Colorado | Unclassified | $12.2M | $215.5M |
| 14 | Credit Unions Chartered in the State of Colorado | Public & Societal Benefit | $11.7M | $246.4M |
| 15 | Pueblo Diversified Industries INC | Employment | $11.4M | $9.2M |
| 16 | Pueblo School for Arts and Sciences | Education | $10.9M | $10.8M |
| 17 | Southern Colorado Community Foundation | Philanthropy, Voluntarism & Grantmaking | $10.2M | $40.9M |
| 18 | Cf&i Retirees Voluntary Employee Beneficiary Association Trust | Unclassified | $8.9M | $26.2M |
| 19 | International Brotherhood of Electrical Workers | Unclassified | $8.5M | $6.7M |
| 20 | Credit Unions Chartered in the State of Colorado | Unclassified | $7.8M | $116.6M |
| 21 | Colorado Bluesky Enterprises INC | Human Services | $7.8M | $8.9M |
| 22 | Parkview Foundation INC | Health Care | $7.5M | $12.0M |
| 23 | Pueblo Community College Foundation | Education | $6.4M | $26.5M |
| 24 | Boys & Girls Clubs of Pueblo County | Unclassified | $5.7M | $3.2M |
| 25 | Neighborworks Southern Colorado | Housing & Shelter | $5.6M | $21.3M |
| 26 | Villa Bella Expeditionary | Education | $5.5M | $17.4M |
| 27 | Spanish Peaks New Alternatives INC | Human Services | $5.4M | $12.2M |
| 28 | Senior Resource Development Agency Pueblo INC | Unclassified | $5.3M | $3.1M |
| 29 | Young Mens Christian Association of Pueblo Colo | Human Services | $4.7M | $20.8M |
| 30 | Pueblo Country Club | Unclassified | $4.1M | $2.1M |
| 31 | Catholic Diocese of Pueblo Foundation INC | Unclassified | $3.8M | $7.4M |
| 32 | Catholic Charities of the Diocese of Pueblo INC | Human Services | $3.7M | $3.2M |
| 33 | Pueblo Cooperative Care Center | Human Services | $3.3M | $1.3M |
| 34 | Spanish Peaks Healthcare Systems | Mental Health & Crisis Intervention | $3.2M | $91.1M |
| 35 | Pueblo Zoological Society | Animal-Related | $3.1M | $5.1M |
| 36 | Northwest Airlines Section 1114 Veba Trust | Mutual & Membership Benefit | $3.0M | $11.2M |
| 37 | Southern Colorado Harm Reduction Association | Mental Health & Crisis Intervention | $2.9M | $3.0M |
| 38 | Center for Disabilities | Human Services | $2.8M | $1.5M |
| 39 | Posada | Housing & Shelter | $2.8M | $11.1M |
| 40 | Roselawn Cemetery Assn. | Unclassified | $2.6M | $4.1M |
| 41 | Sangre de Cristo Arts & Conference Center INC | Arts, Culture & Humanities | $2.6M | $23.0M |
| 42 | Greater Pueblo Chamber of Commerce | Unclassified | $2.6M | $1.2M |
| 43 | Messianic Jewish Bible Society INC | Religion-Related | $2.5M | $8.1M |
| 44 | Mariposa Center for Safety | Human Services | $2.1M | $1.5M |
| 45 | Pueblo Development Foundation | Unclassified | $2.0M | $24.4M |
| 46 | Fraternal Order of Eagles | Unclassified | $1.8M | $1.0M |
| 47 | Pueblo Electrical Joint Apprenticeship and Training Trust | Unclassified | $1.8M | $1.1M |
| 48 | Catholic Charities of the Diocese of Pueblo Works Corp. | Unclassified | $1.6M | $508K |
| 49 | Animal Welfare and Protection Society | Animal-Related | $1.5M | $3.9M |
| 50 | Jackson Foundation | Unclassified | $1.4M | $9.1M |
| 51 | Bessemer Irrigating Ditch Co | Unclassified | $1.4M | $3.7M |
| 52 | Casa of Pueblo | Crime & Legal-Related | $1.4M | $2.0M |
| 53 | Pueblo Hispanic Education Foundation | Education | $1.4M | $1.6M |
| 54 | Southside Childrens Center | Human Services | $1.3M | $520K |
| 55 | Pueblo Economic Development Corp. | Unclassified | $1.3M | $757K |
| 56 | Fraternal Order of Eagles | Unclassified | $1.3M | $1.5M |
| 57 | United Way of Pueblo County Colorado INC | Philanthropy, Voluntarism & Grantmaking | $1.3M | $4.0M |
| 58 | Runyon Sports Complex Commission INC | Recreation & Sports | $1.3M | $332K |
| 59 | Southern Colorado Economic Development District INC | Community Improvement & Capacity Building | $1.2M | $928K |
| 60 | McClelland Childrens Foundation | Education | $1.1M | $626K |
| 61 | Jennie and Albert Gersick Foundation | Philanthropy, Voluntarism & Grantmaking | $1.0M | $4.3M |
| 62 | Pueblo Association of Realtors INC | Unclassified | $996K | $2.5M |
| 63 | Benevolent & Protective Order of Elks of the USA | Unclassified | $963K | $1.1M |
| 64 | Center for American Values INC | Arts, Culture & Humanities | $948K | $374K |
| 65 | Mxv Learning Institute | Public Safety, Disaster Preparedness & Relief | $901K | $122K |
| 66 | Arc of Pueblo INC | Human Services | $860K | $1.1M |
| 67 | East Side Child Care Center INC | Human Services | $846K | $546K |
| 68 | Rosemount Museum | Arts, Culture & Humanities | $838K | $5.9M |
| 69 | Pueblo Crisis Pregnancy Center INC | Health Care | $825K | $1.5M |
| 70 | Christlife Ministries | Crime & Legal-Related | $786K | $1.6M |
| 71 | Southern Colorado Theatre Company | Arts, Culture & Humanities | $785K | $302K |
| 72 | Southern Colorado Spay & Neuter Association | Animal-Related | $766K | $603K |
| 73 | Every Tribe International | International, Foreign Affairs & National Security | $751K | $3.7M |
| 74 | Reijim INC | Unclassified | $746K | $3.2M |
| 75 | Friendly Harbor | Human Services | $668K | $535K |
| 76 | Presbyterian Towers Building Corp. | Unclassified | $658K | $1.4M |
| 77 | Lavert W Hoag Foundation | Philanthropy, Voluntarism & Grantmaking | $643K | $3.3M |
| 78 | Southeastern Colorado Area Health Edctn Ctr for Rural Co Health INC | Health Care | $642K | $955K |
| 79 | Pueblo Child Advocacy Center INC | Crime & Legal-Related | $640K | $901K |
| 80 | Pueblo Rescue Mission | Unclassified | $636K | $2.5M |
| 81 | Ryals Family Foundation | Philanthropy, Voluntarism & Grantmaking | $629K | $476K |
| 82 | Mahlon Thatcher White Foundation | Unclassified | $615K | $3.2M |
| 83 | Habitat for Humanity International INC | Unclassified | $609K | $1.0M |
| 84 | Pueblo Rangers Soccer INC | Recreation & Sports | $551K | $395K |
| 85 | Frank I Lamb Foundation | Unclassified | $537K | $1.6M |
| 86 | Global Surge | Religion-Related | $535K | $323K |
| 87 | Pueblo Historical Aircraft Society | Unclassified | $519K | $881K |
| 88 | The Colorado State Fair Foundation | Arts, Culture & Humanities | $518K | $1.8M |
| 89 | Pueblo County Teachers Association | Employment | $497K | $134K |
| 90 | Assistance League of Pueblo INC | Human Services | $486K | $1.6M |
| 91 | Pueblo Library Foundation | Philanthropy, Voluntarism & Grantmaking | $476K | $989K |
| 92 | Bessemer Historical Society INC | Arts, Culture & Humanities | $434K | $4.1M |
| 93 | Senior Care Systems of Colorado INC | Human Services | $416K | $644K |
| 94 | Police Protective Association of Colorado | Unclassified | $408K | $322K |
| 95 | Blain Family Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $404K | $381K |
| 96 | Pueblo Rape Crisis Services INC | Mental Health & Crisis Intervention | $397K | $246K |
| 97 | Pueblo Education Assoc | Unclassified | $380K | $191K |
| 98 | Richmond Senior Housing INC | Housing & Shelter | $377K | $2.0M |
| 99 | American Legion | Unclassified | $358K | $444K |
| 100 | Union Plaza Senior Housing INC | Housing & Shelter | $354K | $1.0M |